Cell Based Therapies
hiPSCs: Reprogramming towards cell based therapies
... in cell-based therapies have recently shown interim clinical viability and hold great potential for use in regenerative ...such therapies not only carries great ethical debate but also poses ...
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Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives
... between cell-based and drug- based therapies have been explained, with a basic under- standing that cell-based therapies are more heterogeneous and their effects may be ...
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Stem cell-based therapies for ischemic stroke: a systematic review and meta-analysis of clinical trials
... stem cell-based therapies for ischemic stroke have been published; our review evaluated the efficacy and safety of stem cell-based therapies for ischemic ...stem ...
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Cell-based therapies of liver diseases: age-related challenges
... the cell-based therapies of liver diseases with an emphasis on cell donor’s and patient’s ...with cell-based technologies as its integral part is focused on the structural and ...
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Operative Treatment of Knee Cartilage Injuries: A Review of the Current Literature on Non-Cell-Based and Cell-Based Therapies
... to cell-based ...other cell carrier systems, are currently used in clinical practice to treat larger full thickness chondral defects in the ...
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Endothelial Colony Forming Cells (ECFCs) in murine AKI – implications for future cell-based therapies
... different cell types have been shown to undergo a process of mesenchymal transdifferentiation in CKD, namely tubular epithelial cells (Epithelial-to-Mesenchymal Transition – EMT ...stem/progenitor cell ...
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Cell based therapies for intervertebral disc and cartilage regeneration Current concepts, parallels, and perspectives
... Cell based therapies may hold significant promise but will need to be optimised and matched for efficacy that is commensurate with DDD and as such interdisciplinary input with guidance and ...
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Mesenchymal stem cell-based therapies in regenerative medicine: applications in rheumatology
... After traumatic or pathological injury, the capacity of adult articular cartilage to regenerate is limited. Th e current proposed surgeries (microfracture, osteochondral auto- or allografts, or cell-based ...
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Ongoing studies of cell-based therapies for articular cartilage defects in Japan
... Recently, cell-based therapies have generated great interest in the repair of articu- lar cartilage defects and ...a cell scaffold and other devices. Meanwhile, advanced ...
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Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
... Th ere is a demand to make minimally manipulated adipose-derived cell products directly available to the surgeon in the operating room. To meet this need, Cytori Th erapeutics (San Diego, CA, USA) and Tissue ...
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Current understanding of adipose-derived mesenchymal stem cell-based therapies in liver diseases
... Although current studies use various types of differen- tiation protocols, ADMSC-derived HLCs have immature hepatocyte functions; thus, specialists have attempted to develop new methods to improve the functions of HLCs. ...
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Endothelial Dysfunction and Cardiovascular Disease: Critical Target for Cell-Based Therapies
... EPCs express specific markers on the cell surface, including CD133, CD34 and VEGFR-2. Asahara et al. [98] showed that hematopoietic CD34+ cells have characteristic endothelial phenotypes when allowed to ...
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Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies
... specific cell surface antigens (> 95% positive for CD73, CD90, and CD105), and have trilineage differentiation ...Second, cell surface marker expression, which is routinely used to define MSCs, does not ...
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Tissue engineering and cell based therapies, from the bench to the clinic: The potential to replace, repair and regenerate
... primary cell cultures can become senescent or dedifferentiate during the culture ...gous cell therapies have achieved FDA approval for the medical ...
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Conventional and novel stem cell based therapies for androgenic alopecia
... Abstract: The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There ...
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ADVANCED MOLECULAR AND CELL BASED THERAPIES FOR ATHEROSCLEROSIS
... Initial studies in small animal models suggested that the direct injection of unsorted bone marrow cells expanded in vitro improved left ventricular salvage in MI models. This finding has been attributed to the ...
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Novel immune cell-based therapies for atherosclerosis
... Figure 1. Initiation and Progression of Atherosclerosis. Atherosclerosis occurs at sites in the arterial tree where laminar flow is disrupted. A. Atherogenic lipoproteins such LDLs enter the intima, where they are ...
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A biomaterials approach to influence stem cell fate in injectable cell based therapies
... [59]. Cell adhesion is similar to physical adhesion in that the cell membrane must make close molecular contact with the surface [60], and therefore we hypothesised that greater levels of cell at- ...
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Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies
... 3D cell culture could be a promising approach to culture undifferentiated ...using cell aggregates show that cell-cell interactions, as well as cell polarity, are essential ...greater ...
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Clinical trials for stem cell therapies
... timing, cell type and dose, and delivery ...stem cell secretions or cytokines released at the site of injury and the degree of cardio-repair that may be clinically relevant ...than cell-based ...
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