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Novel immune cell-based therapies for atherosclerosis

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Figure 1. Initiation and Progression of Atherosclerosis. Atherosclerosis	 occurs	 at	 sites	 in	 the	 arterial	 tree	 where	 laminar	 flow	 is	 disrupted.	 A.	 Atherogenic	 lipoproteins	 such	 LDLs	 enter	 the	 intima,	 where	they	are	modified	and	aggregat
Figure 5. Immune responses in atherogenesis. OxLDL	 and	 coronary	 risk	 factors	 activate	 the	 endothelium	 and	 induce	 adhesion	 molecule	 expression.	 Monocytes	 migrate	 into	 the	 subendothelial	 space	using	adhesion	molecules,	differentiate	into	ma
Table 1. Primer Pairs used for qPCR analysis.	 The	 relative	 expression	 of	 genes	 was	 determined	 relative	to	the	average	expression	of	the	three	household	genes:	ribosomal	protein	36B4,	hypoxanthine	 phosphoribosyltransferase	(HPRT),	and	60S	ribosomal
Figure 1. OxLDL and epoxomicin induce apoptosis in DCs. Quantification	of	apoptotis	in	DCs	by	flow	 cytometry.	DCs	were	stimulated	with	indicated	amounts	of	oxLDL.	Early	apoptosis	was	determined	as	 AnnexinV + PI -	 and	late	apoptosis	as	AnnexinV + PI -	 b
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