Cell cycle and G 2 /M checkpoint control
Anticancer drug targets: cell cycle and checkpoint control
... tumor cell lines expressing wild-type Rb appear incapable of G1 arrest in response to ...epithelial cell lines exposed to ...treatment, cell lines that do not arrest in G1 demonstrate delay in S ...
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Nek family of kinases in cell cycle, checkpoint control and cancer
... Taken together, these cell-based studies suggested that Nek6/7/9 might be critical for regulation of microtubule organization during mitosis. Indeed, targeted disruption of the Nek7 gene in mice revealed that this ...
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THE ROLE OF P38 MAPK IN CELL CYCLE CHECKPOINT CONTROL FOLLOWING DNA DAMAGE
... Author: Mark Phong Page 176 of 291 pathways are activated and behave independently of p38 regulation. Some key genes that stick out strongly at this time point include anti-apoptotic genes relating to the IAP proteins ...
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Coupling of the cell cycle and metabolism in yeast cell-cycle-related oscillations via resource criticality and checkpoint gating
... turn control the checkpoints of the system, which control the location of the cells, resulting in two-way ...Start checkpoint is triggered metabolically – can result in a locally stable solution ...
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Cell cycle control and cancer
... mitotic checkpoint are the two related protein kinases hBub1 and hBub1R, and a third protein ...mitotic checkpoint 55 . The importance of this checkpoint in maintaining genome integrity is empha- ...
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PTEN is a negative regulator of mitotic checkpoint complex during the cell cycle
... Flag-tagged Mad2 and Cdc20 were obtained from Addgene. Plasmids were transfected into HEK293T with either LF2000 (Invitrogen) following the manufactur- ers’ protocol. Transfection efficiency was estimated to be between ...
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Original Article SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis
... We recruited consecutive patients with endo- metrial carcinomas to a discovery cohort, from October 2004 to May 2013. The fresh endome- trial specimens were immediately frozen at -80°C until RNA extraction. 217 human ...
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Extragenic suppressors of Schizosaccharomyces pombe rad9 mutations uncouple radioresistance and hydroxyurea sensitivity from cell cycle checkpoint control.
... pombe cells containing a mutation within the rad9 gene are dramatically sensitive to UV light and ionizing radiation, relative to wild-type strains (SCHUPBACH.. 1971), indi[r] ...
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A Journey in Science: Cell-Cycle Control
... the cell division cycle knowledge of the cell cycle is mostly in the arena of ...uncontrolled cell division due to damage to the controls regulating the growth of cells and their ...
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Switching the Cell Cycle. Kip-Related Proteins in Plant Cell Cycle Control 1
... In strong Arath;KRP2-overexpressing lines, CDK ac- tivity is inhibited in both mitotically dividing and endoreduplicating leaf tissues. By contrast, in weak overexpressing lines, only the mitotic CDK-cyclin com- plexes ...
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Timing is everything: cell cycle control of Rad52
... both cell viability and the maintenance of genomic ...phase checkpoint, and undergoes posttranslational modification events such as phosphorylation and ...
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CYCLIN DEPENDENT KINASES AND CELL CYCLE CONTROL
... the cell cycle usually occur in a fixed sequence, and if an early event such as S-phase is incomplete then a later event such as mitosis becomes ...the cell monitors or “checks” cell ...
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Abnormal Micronuclear Telomeres Lead to an Unusual Cell Cycle Checkpoint and Defects in Tetrahymena Oral Morphogenesis
... (category 2). We used WT control cells from category ...the cell number was quantified as ...(passage 2), and only 8% divided close to ...for 2 days. These results are consistent with ...
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Involvement of RAD9-Dependent Damage Checkpoint Control in Arrest of Cell Cycle, Induction of Cell Death, and Chromosome Instability Caused by Defects in Origin Recognition Complex in Saccharomyces cerevisiae
... RAD9-dependent cell cycle checkpoint control in the maintenance of chromosomes in orc1 temperature-sensi- tive mutant ...and cell cycle arrest of orc2-1/orc2-1 diploid cells at ...
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Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control.
... in G 2 /M. We developed a protocol to infect 100% of a T-cell population with HIV and therefore could determine that Vpr is primarily cytostatic rather than ...in G 2 , ...
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Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies
... of cell index of UMSCC-6 (HPV − base of tongue carcinoma) or − 9 (HPV − oral tongue carcinoma) cells via impedance ...of cell index when added to both UMSCC-6 and -9 cells ...UMSCC cell lines ...haNK ...
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Sum1, a Highly Conserved WD-Repeat Protein, Suppresses S-M Checkpoint Mutants and Inhibits the Osmotic Stress Cell Cycle Response in Fission Yeast
... normal cell growth and division. In addition to restoring checkpoint control, overexpression of sum1 1 inhibits the normal cell cycle response to osmotic ...for cell cycle ...
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Cell Cycle Control 116. Tumor Suppressors Prevent Uncontrolled Cell Division. Regulation of the Cell Cycle: A Closer Look
... 6.4 Cell Cycle Control 117 Regulation of the Cell Cycle: A Closer Look Tumor suppressors are not the only proteins guarding ...the cell cycle, additional proteins ...
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The cell cycle checkpoint inhibitors in the treatment of leukemias
... different cell cycle checkpoint in- hibitors against different kinds of hematologic as well as solid tumors, as single agent, or in combination with a wide number of ...of cell cycle ...
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A DNA-Damage-Induced Cell Cycle Checkpoint in Arabidopsis
... a G 2 -phase cell cycle ...the cell cycle unimpeded were recovered in the uvh1 background; the resulting irradiated plants are genetically ...of cell cycle ...
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