cell-cycle control
Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma
... of control over the cell cycle is critical to tumor suppression, but the relationship between dynamic carcinogen exposure and the targeting and induction of tu- mor-specific methylation profiles is ...
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Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices
... ON control) were cloned into the expression cassette for the G2/M regulatory node ...the control of a CMVTetO2 promoter and encoded on a plasmid backbone that allowed site-specific stable in- tegration into ...
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A Journey in Science: Cell-Cycle Control
... their cell cycle more rapidly than they could grow, and as a consequence were being advanced prematurely through a rate- limiting process of the cell cycle that was controlling the overall ...
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Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control
... towards cell cycle regulation. SAOS2 cell cycle arrest assays showed that disruption of three separate binding surfaces were necessary to inhibit pRB-mediated cell cycle ...to ...
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Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control.
... eight cell lines in response to EZH2 inhibition at 6 days using qRT-PCR for the genes examined above plus other genes involved in cell cycle control (Figure 4b and Supplementary Figure ...
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Cell Cycle Control of Kaposi's Sarcoma-Associated Herpesvirus Latency Transcription by CTCF-Cohesin Interactions
... host cell survival. A major latency control region has been identified upstream of the divergent promoters for the multicistronic transcripts encoding LANA (ORF73), vCyclin (ORF72), and vFLIP (ORF71) and ...
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Investigating E2F independent cell cycle control and tumor suppression by pRB
... towards cell cycle regulation. SAOS2 cell cycle arrest assays showed that disruption of three separate binding surfaces were necessary to inhibit pRB-mediated cell cycle ...to ...
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Cell cycle control of Notch signaling and the functional regionalization of the neuroepithelium during vertebrate neurogenesis
... important cell cycle molecules are target genes of various miRNAs (le Sage et ...is cell-cycle dependant, since it has been observed its strongest repressive potential in the S and S/G2 phases ...
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Functional analysis of the cell cycle control gene cdc18 in Schizosaccharomyces pombe
... The activatory phosphatase in fission yeast is know n as cdc25p (Fig. 1.2 B). It was cloned by com plem entation of the cdc25-22 tem perature sensitive m utant (Russell and N urse, 1986). Initial results indicated th at ...
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Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity
... a cell density of 10 6 cells/ml under the conditions of ...rotation. Cell suspensions were carefully mixed with the activator solution (CD3/CD28 or PMA) or control solution (only medium) and filled ...
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Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control
... stable cell cycle arrest provoked by a variety of potentially oncogenic stimuli, such as telomere shortening, DNA damage or activation of certain oncogenes ...to cell cycle re-entry, ...
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Yeast UBL-UBA proteins have partially redundant functions in cell cycle control
... Ddi1 homodimerization is necessary for pds1–128 rescue In addition to their abilities to bind ubiquitin and the pro- teasome, Dsk2, Ddi1 and Rad23 share the ability to form homodimers [22,24]. The importance of ...
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Crosstalk Between Soluble Factors and Cell Cell Interactions: Implications for Cell Cycle Control and Tumor Development
... Mouse monoclonal capture antibodies against either E-cadherin or β-catenin (BD Transduction Laboratories, San Jose, CA) were diluted to 2.5 µ g/ml in Tris-buffered saline (10 mM Tris (pH 8.0), 150 mM NaCl) containing ...
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Cell cycle control of endoplasmic reticulum structure and Ca2+ -release in the mouse oocyte and early embryo
... The failure of in vitro maturation systems to support these ‘On’ pathways is an attractive potential contributor to the developmental failure of IVM oocytes. It is now well established that the fidelity of Ca^^ ...
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The extracellular matrix as a cell cycle control element in atherosclerosis and restenosis
... In vivo, vSMCs are surrounded by a simple basement mem- brane that contains collagen IV and laminin, with small amounts of fibronectin. As mentioned above, vSMCs undergo a phenotypic transformation from a contractile to ...
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The ubiquitin-proteasome system in glioma cell cycle control
... G2/M cell cycle arrest and/or apoptosis, whenever indicated as a response to various stressors, could not be ensured without the critical involvement of p53, whose levels and activation within the ...
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BRANCHLESS TRICHOMES links cell shape and cell cycle control in Arabidopsis trichomes
... The BLT gene is unique in the Arabidopsis genome, with the most closely related Arabidopsis genes clearly being paralogs (see Fig. S3 in the supplementary material). Both monocots and dicots have BLT homologs (see Fig. ...
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Viral cyclin disruption of mammalian cell cycle control mechanisms.
... U ntil now , precise identification of m am m alian CAK rem ained elusive. The cyclin H /c d k 7 complex can activate cdc2, cdk2 and cdk4 (Fisher and Morgan, 1994; Makela et al., 1994). There w as uncertainty as to w ...
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The role of Ras and its downstream targets on cell cycle control
... on cell cycle regulatory proteins was ...single cell suspension was ...assessed. Cell lysates were separated by SDS-PAGE and analysed by Western ...
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Cell cycle control of polyomavirus-induced transformation.
... To assay whether differences in virus uptake at different phases of the cell cycle account for the differences in transformation, we infected cells at various times after release from Go[r] ...
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