Cell cycle progression (A) and inhibition (B). The cell cycle is
Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells
... Drugs that are both cytotoxic on resting CLL cells and able to inhibit CLLs’ activation and subsequent proliferation would be beneficial in the treatment of this disease. Metformin was first synthesized and found to ...
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WWP2 is required for normal cell cycle progression
... p-Akt 473 signals start to rise around the mitotic entry, coinciding with the appearance and increase of cyclin B. It is possible that Akt activity may be involved in the positive regulation of expression of ...
7
Pharmacological GLI2 inhibition prevents myofibroblast cell cycle progression and reduces kidney fibrosis
... myofibroblast cell-cycle progression in cultured mesenchymal stem cell–like ...myofibroblast-specific cell-cycle arrest mediated this ...subsequent cell-cycle ...
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Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines
... two cell lines responded earlier to lycopene, reaching maximal de- crease of viability already at 48 ...four cell lines that responded to lycopene reached the same level of cell number decrease only ...
9
Regulation of genome stability and cell cycle progression by SUMOylation
... Abstract Loss of SUMO modification in mice causes genomic instability due to the missegregation of chromosomes. Currently, little is known about the identity of relevant SUMO target proteins that are involved in this ...
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Alteration of cell cycle progression by Sindbis virus infection
... the inhibition of RNA and protein synthesis is able to affect the expression of cell cycle regulators and cell cycle ...most cell cycle regulators exhibited no decrease at ...
7
Cell cycle progression is regulated by intertwined redox oscillators
... Fig. 2 The logic of metabolic cell cycle. Cytosolic NAD+/NADH, NADP+/NADPH, ATP/ADP ratios and intracellular pH (pHi) are reported to oscillate through eukaryotic cell cycle. Mitosis is often ...
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Predicting stem cell fate changes by differential cell cycle progression patterns
... Stem cell self-renewal, commitment and reprogramming rely on a poorly understood coordination of cell cycle progression and execution of cell fate ...stem cell cycle ...
12
Bayesian Statistical Models of Cell-Cycle Progression at Single-Cell and Population Levels
... as cell density in a field of view increases, the ability to track in- dividual cells and cell lineages ...Increasing cell density over the course of a time-lapse movie doesn’t just limit sample ...
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Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression
... that cell-size check- points are unnecessary to explain how proliferating Schwann cells maintain their size in a particular ...of cell-size checkpoints in yeasts is that they can rapidly change the size at ...
10
Capsule Growth in Cryptococcus neoformans Is Coordinated with Cell Cycle Progression
... Brazil b ; Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, Paris, France c ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA d ABSTRACT The fungal ...
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A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis
... b Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA c Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA ABSTRACT ...
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Investigating the role of NSMCE2 in cell cycle progression and genome maintenance
... knockout cell line, it is possible that the slowed S phase progression is not as severe as the ligase- dead cells, meaning that replication can be completed in time leaving no unresolved ...knockout ...
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Developmental and Cell Cycle Progression Defects in Drosophila Hybrid Males
... We also found that very few of these brain cells in male hybrids are in S phase, as determined by BrdU incorporation. These data suggest that cells in hybrid males are arrested in either the G 1 or G 2 phases of the ...
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Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression
... Dap160 and aPKC maintain proliferating neuroblast pool size We find that both dap160 and aPKC mutant larvae have a partial reduction in the number of proliferating neuroblasts (this work; Lee et al., 2006b). This may be ...
8
Morphogenesis and the Cell Cycle
... mother cell in Saccharomyces cerevisiae have provided foundational paradigms for the mechanisms of polarity establishment, cytoskeletal organization, and cyto- ...the cell- cycle-regulatory ...
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Phasing in on the cell cycle
... of cell cycle regulation and ...the cell cycle can undergo protein phase ...the cell cycle or are associated with cancer, have been recently found to phase separate from the test ...
8
MicroRNAs and the cell cycle
... induce cell cycle arrest at the G1 phase by targeting critical cell cycle regulators such as CDK1, CDK2 and CDK6 as well as cyclins (D1, D3 and E1) [24,26 –28] ...major cell ...
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in the Yeast Cell Cycle
... arrest cell cycle progression, but rather than occurring at the time of nutrient limitation, the arrest is delayed until the cells reach G1 (Mendenhall Discovering Genetic Regulatory Networks and ...
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IGFBP7 inhibits cell proliferation by suppressing AKT activity and cell cycle progression in thyroid carcinoma
... Different types of thyroid cancer have unique gene mutations, suggesting that different molecular mecha- nisms may be related to the development and progres- sion of thyroid cancer. Point mutations in the BRAF or RAS ...
13