Cell–extracellular matrix adhesion
Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer
... The F12 gene encodes for the plasma coagulation factor XII (FXII) which is a serine protease precursor that plays a role in the normal blood clotting process [56]. In addition to its role in blood clotting, FXII ...
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Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer.
... Tumour cell-extracellular matrix (ECM) interactions are fundamental for discrete steps in breast cancer ...cancer cell adhesion to ECM proteins present in the microenvironment is ...
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Clara cell adhesion and migration to extracellular matrix
... other matrix substrates in this ...provisional matrix [18]. The switch predominantly favours provisional matrix (Fn and/or vitronectin) binding integrins (α 5 and α v ), over the colla- gen and ...
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Epithelial Cell Adhesion to Extracellular Matrix Proteins Induces Tyrosine Phosphorylation of the Epstein-Barr Virus Latent Membrane Protein 2: a Role for C-Terminal Src Kinase
... Investigation of LMP2A deletion mutants indicated that the same regions that are important for LMP2A function in B cells are important for its phosphorylation in epithelial cells. Mu- tants with deletions of the ITAM, ...
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Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells
... Erk: Extracellular-signal-regulated kinase; FAK: Focal Adhesion Kinase; FITC: Fluorescein Isothiocyanate; HUVECs: Human Umbilical Vein Endothelial Cell; MMPs: Matrix Metalloproteinases; MTT: ...
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Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix
... fibroblasts) cell lines (Fig 3A). Cell lines demonstrated similar adhesion profiles on FN, but WA17 cells displayed increased adhesive capacity for Col VI compared to A9 cells (Fig ...the ...
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The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review
... the adhesion sites, keeping FAK in the ...focal adhesion maturation, and FAK nuclear localization in non-small cell lung cancer (NSCLC) ...cellular-extracellular matrix (ECM) inter- ...
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CD151-mediated adhesion is crucial to osteosarcoma pulmonary metastasis
... in patients with metastasis than patients without, which may be due to the small sample size. Larger patient cohort clearly suggested that CD151 expression correlates with poorer prognosis. We also analyzed the effect of ...
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Influence of extracellular matrix on the proliferation and adhesion properties of stem cells derived from different sources
... The adhesion of these cells to culture surfaces was much slower than in other cell ...analyzed matrix proteins, the adhesion of hair follicle stem cells was the fastest on the control ...
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Mathematical modelling of cancer invasion : the multiple roles of TGF β pathway on tumour proliferation and cell adhesion
... Cellular adhesion, i.e. cell–cell and cell–matrix adhesion, and cellular proliferation are fundamental features of multicellular organisms, linked to maintenance of order in the ...
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Mathematical modelling of cancer invasion : implications of cell adhesion variability for tumour infiltrative growth patterns
... to cell adhesion (Weinberg, ...dependent adhesion molecules that interact with intra-cellular proteins, most notably β-catenin, to form adherence junctions between cells in human tis- sue (Juliano, ...
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Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion.
... increased cell areas and YAP ratios (Figure 4G; Figure ...during cell spreading (Das et ...focal adhesion maturation (Figure 4F) and a FAK-dependent, ROCK-indepen- dent pathway triggered by new ECM ...
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Regulation of cell survival by CIB1, a new modulator of 3-phosphoinositide-dependent protein kinase 1 (PDK1)
... function. Akt is well known to translocate from cytosol to the plasma membrane upon extracellular growth factors stimulation or matrix adhesion. On the contrary, RSK is mainly located to cytosol. ...
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Phospholipids reduce gastric cancer cell adhesion to extracellular matrix in vitro
... be adhesion of tumour cells to mesothelial cells or extracellular matrix components ...[8]. Cell-matrix interactions are promoted by transmembrane receptors with integrins as a major ...
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Identification of the soluble form of tyrosine kinase receptor Axl as a potential biomarker for intracranial aneurysm rupture
... sponse, cell adhesion, extracellular matrix (ECM), protein synthesis or protein degradation, transport, apoptosis and anti-apoptosis, cell proliferation/differentiation/migration, ...
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Nanomechanical measurement of adhesion and migration of leukemia cells with phorbol 12-myristate 13-acetate treatment
... The adhesion and traction behavior of leukemia cells in their microenvironment is directly linked to their migration, which is a prime issue affecting the release of cancer cells from the bone marrow and hence ...
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Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo
... Development of the human embryo depends on the ability of first trimester cytotrophoblastic stem cells to differentiate and invade the uterus. In this process, transient expression of an invasive phenotype is part of ...
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Role of Rap Signaling in the Regulation of ERK Activation and Cell-Cell Adhesion
... Although the TSH receptor couples to multiple G proteins (Laugwitz et al., 1996), most of the effects of TSH are mediated through Gsα and cAMP (reviewed in (Kimura et al., 2001; Medina and Santisteban, 2000)). Cyclic AMP ...
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Regulation of TGF-Β1-Induced Apoptosis and Epithelial-Mesenchymal Transition by Matrix Rigidity
... or cell culture substrate can be measured by a variety of methods, including rheology, confined compression, tensile testing, microindentation, and atomic force ...
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Bifidobacterium bifidum Extracellular Sialidase Enhances Adhesion to the Mucosal Surface and Supports Carbohydrate Assimilation
... contrast, adhesion of the wild-type strain to PCM was decreased when HMO was used as the sole carbon source, while siabb2 mutation decreased ...bifidum adhesion to PCM in all media ...of adhesion of ...
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