Cell heterogeneity
Single-Cell Analysis of the Impact of Host Cell Heterogeneity on Infection with Foot-and-Mouth Disease Virus
... that heterogeneity in cell size and cell inclusion number influenced FMDV ...that cell size and inclusions affected the FMDV adsorption ...that cell size and number of inclusions might ...
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Restoring physiological cell heterogeneity in the mesenchyme during tooth engineering
... about cell diversity and patterning in the ...of cell surface markers in the mesenchyme was investigated by immunostaining in: 1) embryonic mouse molars at embryonic day 14, as the initial cell ...
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Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing
... resolving cell-to-cell variations and fail to identify rare cells that may play a crucial role in physiological or pathological ...the cell state, reveal intrinsic regulatory networks, uncover ...
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Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity
... tuft cell protein expression profiles. Tuft cell stability under these conditions is consistent with the long-lived nature of tuft cells relative to other differentiated intestinal cell types (16); ...
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Multiple cell and population level interactions with mouse embryonic stem cell heterogeneity
... mammalian cell lines, there is likely to be more than one critical step controlling transition through the cell ...multiple cell cycle transitions are sensitive to ...
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GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images
... Many automatized approaches have been developed to address these issues, and Columbus and CellProfiler are two state of the art softwares used to benchmark the per- formance of GoIFISH. These have been developed for ...
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Dynamic stem cell heterogeneity
... stem cell identity has been localized to a permanent and discrete region of the hair follicle known as the bulge ...the cell cycle in response to signals derived from the base of the niche, and give rise to ...
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Supervised learning methods in modeling of CD4+ T cell heterogeneity
... In another study Mei et. al. presented ENISI Visual, an agent-based simulator for modeling enteric immunity [10]. ENISI Visual provides high quality visualizations for simulating gut immunity to enteric pathogens and is ...
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Intracellular polymerization of sickle hemoglobin Effects of cell heterogeneity
... sickle cell anemia can be used with the theory to predict the amount of polymer in unfractionated ...that heterogeneity in intracellular hemoglobin concentration causes the critical oxygen saturation for ...
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Interpreting heterogeneity in intestinal tuft cell structure and function
... Recent developments in single-cell RNA sequencing (scRNA-Seq) have revealed further insights into tuft cell heterogeneity. Haber et al. applied droplet-based scRNA-Seq to characterize the tran- ...
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Using single-cell multiple omics approaches to resolve tumor heterogeneity
... CEL-Seq: cell expression by linear amplification and sequencing; CIViC: clinical interpretation of variants in cancer; CNV: copy number variation; CNVkit: copy number variation kit; CTC: circulating tumor cells; ...
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Dynamics and Heterogeneity of Gene Expression and Epigenetic Regulation at the Single-Cell Level
... reporter cell lines for Nanog and Oct4, each containing a histone 2B (H2B)- tagged fluorophore expressed under the control of the corresponding promoter (Figure ...reporter cell lines for ∼50-hour periods ...
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Cell adhesion heterogeneity reinforces tumour cell dissemination: novel insights from a mathematical model
... adhesion heterogeneity reinforces tumour cell dissemi- nation from dense cell populations of otherwise identi- cal ...cells. Cell dissemination is reduced when adhesion receptor expression ...
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Management and potentialities of primary cancer cultures in preclinical and translational studies
... of the matrix composition can be selected from a pattern of synthetic polymers, i.e. poly(d,l-lactide) (PDLLA), poly(l-lactic-co-glycolic acid) PLGA, polystyrene (PS), poly(methyl-methacrylate) (PMMA), poly(caprolactone) ...
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MR Imaging Features of High Grade Gliomas in Murine Models: How They Compare with Human Disease, Reflect Tumor Biology, and Play a Role in Preclinical Trials
... cent review by Amarasingh et al 51 assessed the impact of che- motherapy drug research in neuro-oncology. These authors performed a stratified meta-analysis on the efficacy of nitro- sureas (carmustine and lomustine) in ...
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REVIEW The Impact of Tumor Eco-Evolution in Tumor Sampling
... Chowdhury, S., Rudman, S., Lynch, J., Fernando, A., Stamp, G., Nye, E., Jabbar, F., Spain, L., Lall, S., Guarch, R., Falzon, M., Proctor, I., Pickering, L., Gore, M., Watkins, T.B.K., Ward, S., Stewart, A., DiNatale, R., ...
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The Trade-Induced Effects of the Services Directive and the Country-of-Origin Principle. CEPS ENEPRI Working Papers No. 44, 24 April 2006
... little heterogeneity and a high value much ...The heterogeneity indicator is −following an OECD classification− further decomposed into separate indicators for five different areas of product-market ...the ...
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Single cell sequencing reveals karyotype heterogeneity in murine and human malignancies
... mitotic abnormalities died in this experiment (n = 10). Even though this indicates that tetraploidisation events are selected against in a tissue culture setting, this still could be different in vivo, given that whole ...
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Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis
... single cell FASTQ files by separating reads based on the Illumina Nextera index ...single cell FASTQ files and aligned to the human reference genome GRCh38 downloaded from Ensembl using the STAR aligner ...
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Incomplete cellular reprogramming of colorectal cancer cells elicits an epithelial/mesenchymal hybrid phenotype
... be grouped into three major clusters based on their ex- pression patterns (Fig. 3a; see also Additional file 2: Table S2). Cluster I miRNAs were highly or moderately expressed in ESC cells, consistent with the inclusion ...
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