cell responses
Reduced Hepatitis B Virus (HBV)-Specific CD4+ T-Cell Responses in Human Immunodeficiency Virus Type 1-HBV-Coinfected Individuals Receiving HBV-Active Antiretroviral Therapy
... T-cell responses in subjects with diverse genetic backgrounds were charac- terized by using a library of 15-mer peptides overlapping by 11 amino acids and spanning all HBV ...T-cell responses ...
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Effect of anti-IgE therapy on food allergen specific T cell responses in eosinophil associated gastrointestinal disorders
... T cell proliferation. Second, anti-IgE may inhibit mast cell and basophil acti- vation in vivo, [8], which may result in decreased IL-4 expression, the lack of which could inhibit Th2 cell dif- ...
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T cell and B cell responses in a rat model of rheumatic heart disease
... T cell responses in vivo are complex and are dependent on the number of precursor T cells available for activation and MHC affinities for antigen, in addition to antigen type and dose or timing of secondary ...
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T cell and B cell responses in a rat model of rheumatic heart disease
... immunised rats .................................................................................... 149 Figure 7.9 Immunohistochemical analysis of rat heart tissue .............................. 150 Figure 8.1 ...
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Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site
... B-cell responses, and functionally important antibody effector responses, such as NAb and ...B-cell responses, (iii) early induction of anti-HIV-1 binding and NAbs, and (iv) ...T-helper ...
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Glatiramer acetate (Copaxone) therapy induces CD8+ T cell responses in patients with multiple sclerosis
... Multiple sclerosis (MS) is an inflammatory, demyeli- nating disorder of the CNS with varied clinical presen- tations that range from clearly defined relapses and remissions (RRMS) to slow accumulation of disability with ...
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Rhesus Macaque B Cell Responses to an HIV 1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis
... Utility of 5= RACE PCR for unbiased capture of NHP anti- body repertoire. The unbiased analysis of human B-cell reper- toires has been reported (41, 42). Such methods can in principle be adapted to monitor the ...
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Human T cell responses to dengue virus antigens Proliferative responses and interferon gamma production
... host-immune responses. We have begun to analyze human T cell responses to dengue antigens in vitro to explain the possible role of T lymphocytes in the pathogenesis of these ...proliferative ...
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B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection
... B cell-deficient ...T cell responses to Friend virus (FV) infection were more robust in ...(B cell-deficient) mice than in wild-type (wt) mice ...T cell responses are strongly ...
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New Methods for Assessing T-Cell Responses
... The existence of tumor progression or chronic infection de- spite the presence of specific lymphocytes highlights the im- portance of the functional characterization of these T cells. ELISPOT and intracellular cytokine ...
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Evaluation of Endothelial Cell Responses to Elevated Glucose
... macrovascular damage characteristic of diabetes. This occurs when stress-sensitive pathways are activated, notably the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. ROS and inflammatory ...
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Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus Induced Autoimmunity
... The lack of NKDCs in the CNS of normal mice suggests that NKDCs likely derive from a circulating population; however, it is also possible that TMEV infection may induce the differen- tiation of a CNS-resident CD11c ...
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Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... B cell differentiation is tightly controlled by a transcrip- tion regulation ...plasma cell-related genes, and downregulate the B cell identity ...plasma cell formation, which mainly functions ...
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Transcriptional profiling of host cell responses to encephalomyocarditis virus (EMCV)
... negative regulation of NF-kappa B signaling (Table 3). A20 was demonstrated to inhibit TNF induced apoptosis [28]. Furthermore, a recent study showed that deficiency of A20 in myeloid cells improved the resistance ...
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B cell responses in murine influenza
... TABLE 7.2 B Cell Memory in Murine Influenza Lung ASCs generated in vitro following: Primary Inoculation Spleen IgM IgG IgA IgM IgG IgA ++ ++ ++ +++ +++ + ++ ++ ++ ++ ++ - + + Secondary I[r] ...
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Long Lasting T Cell Independent IgG Responses Require MyD88 Mediated Pathways and Are Maintained by High Levels of Virus Persistence
... T cell-independent (TI) B cell responses due to their repetitive epitopes and the induction of innate ...T cell help is thought necessary for the development of long-lasting antiviral antibody ...
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Interactions of CD4+ and CD8+ human T lymphocytes from malaria unprimed donors with Plasmodium falciparum schizont stage
... Monoclonal antibodies to CD3 or the aji-chain T-cell receptor blocked cloned T-cell responses to the schizont extract, and although the responses of the majority of the CD4+ or CD8+ T-ce[r] ...
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Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8+ T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression
... T cell responses to tumor antigen in vitro and in vivo ...the cell surface by matrix metalloproteinases ADAM10 and ADAM17, yielding a soluble Tim-3 ectodomain (IgV-like domain and mucin domain) ...T ...
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Utilizing the adjuvant properties of CD1d dependent NK T cells in T cell–mediated immunotherapy
... existing responses seen in the other control ...T cell phenotype induced by oral administration, which can be effectively over- come by the adjuvant capacity of the iNKT cell ...T cell ...
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Theiler's Virus Infection Induces a Predominant Pathogenic CD4+ T Cell Response to RNA Polymerase in Susceptible SJL/J Mice
... T-cell responses exhib- iting an altered cytokine profile (23, ...limited cell types directly supporting viral replication will produce noncapsid ...
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