Cell Senescence
mTOR pathway activation drives lung cell senescence and emphysema
... inhibits cell senescence in COPD, independently of its effect on the ...affected cell senescence or the SASP in a curative ...against cell senescence, we examined the ...
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Original Article Defective proliferative potential of MSCs from pediatric myelodysplastic syndrome patients is associated with cell senescence
... controls. Cell cycle was detected by flow cytometry following PI staining, as well as cell senescence was evaluated by β-galactosidase staining and telo- mere ...cellular senescence than ...
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T cell senescence and CAR-T cell exhaustion in hematological malignancies
... Treg cell suppression in aging, is accumulated in tumor sites creating hypoxic microenvi- ...T cell senescence and disrupt the tumor microenviron- ment in ...
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Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
... that senescence can occur in cells that have compromised p53 [15, 43, ...of senescence in certain contexts ...accelerated cell senescence that leads to the generation of AD32 cells, despite ...
10
Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
... cellular senescence and inflammation in cultures of NCI-H441 cells, a human lung adenocarcinoma cell line with Clara cell ...no cell deaths occurred when NCI-H441 cells were exposed to BrdU at ...
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Abnormalities of age-related T cell senescence in Parkinson’s disease
... T cell phenotyping to specifically explore cell subsets and markers relevant to activation and replicative ...T cell population in our cohort, nor assess changes in T regulatory cells, which have ...
8
Obesity accelerates T cell senescence in murine visceral adipose tissue
... over a given time period, whereas the Spp1 gene may be activated constitutively to a much lesser extent in VAT macrophages. The PD-1 receptor plays an important role in resolving inflammation by negatively regulating T ...
15
Null cell senescence and its potential significance to the immunobiology of aging
... null cell compartments of human bone marrow and mouse spleen were arbitrarily divided into three subpopulations based upon the ability of cells to acquire T or B cell membrane markers when incubated with ...
5
Original Article MicroRNA-22 suppresses metastasis by targeting SNAI1 in the ovarian cancer cell line SKOV-3
... induces cell apoptosis in clear ovarian carcin- oma; restores the cell senescence in senescent human fibroblasts; acts as an anti-angiogene- sis factor in colon cancer cell lines; inhibits ...
10
Is senescence-associated β-galactosidase a marker of neuronal senescence?
... cellular senescence is the activity of senescence- associated- β-galactosidase ...of senescence in aging ...of senescence, namely, double- strand DNA breaks ...a senescence-like ...the ...
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<em>Klotho</em>, stem cells, and aging
... to senescence and depletion of stem cells, which consequently triggers tissue atrophy and ...inhibit cell senescence and preserve stem ...aging, cell senescence, klotho, stem cells, ...
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Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice
... stem cell senescence and functional improvements, in that suppression of Mitofilin is enough to mimic a senescent phenotype in SAMR1 BMMSCs, and Mitofilin upregulation is indispensable for the positive ...
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Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer
... in cell culture) assay in mammary epithelial cells (16N) and breast tumor cells (NT) that were both isolated from a single patient and found that COX5B was upregulated in breast cancer cells compared with normal ...
12
The effects of astragalus polysaccharide on zebrafish cell apoptosis and senescence
... Current studies suggest that development of anti-aging drugs from Chinese medical herbs may be one of the po- ssible interventions [10,35]. AP has a variety of biologi- cal activities and pharmacological functions and ...
7
Anti stress gene response in cell and tissue ageing : role of transcription factor NF E2 related factor 2 and effect of dietary activators
... in cell senescence – such as senescence-associated secretory phenotype (SASP) – which are linked to functional changes in pathophysiology and likely contribute to declining organ function with ...
321
Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α
... increased cell senescence and apoptosis of HCC cells, indicating that targeting undifferentiated cancer cells (especially CSCs) by PRMT5 may be a promising approach for HCC ...
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DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
... [13]. Senescence per se has long been known to be a mechanism halting the replication of cells that have acquired potentially hazardous genetic mutations [2, ...that cell senescence is crucially ...
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Vol 71, No 2 (2019)
... powerful cell destructive potential independent of the intimate contact of the cells and the dental ...Apoptotic cell death was followed by pro- gressive failure of cell membrane function, leading to ...
10
<p>MLL3 promotes the senescence of esophageal squamous cell carcinoma</p>
... ESCC cell growth as revealed by MTT assay (Figure ...ESCC cell growth (Figure ...ESCC cell senescence based on β -gal staining (Figure ...the senescence of ESCC ...
8
The antioxidative defense system is involved in the premature senescence in transgenic tobacco (Nicotiana tabacum NC89)
... leaf senescence is nutrient salvage involving the hydrolysis of macromol- ecules and their subsequent remobilization to other plant parts [37, ...of senescence of transgenic ...
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