Cell Trafficking
Engineering a multicellular vascular niche to model hematopoietic cell trafficking
... of cell behavior in dense tissue [5, 9, 10, 14, ...gle cell visualization of hematopoietic stem and progeni- tor cell (HSPC)-endothelial interactions, [6, 14, 16–20], although trafficking ...
14
Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy
... PMN-MDSC trafficking into ...immunosuppressive cell trafficking may more effectively rescue effector immune ...for trafficking into tumors ...neutrophilic cell trafficking into ...
13
Immune cell trafficking from the brain maintains CNS immune tolerance
... impeded cell egress from the CNS, perhaps identifying a role for immune cell trafficking along the RMS in the resolution of CNS ...inflammatory cell(s) that might be detrimental in this ...
15
Novel 89Zr cell labeling approach for PET-based cell trafficking studies
... Athymic nude Foxn1 nu mice (2 months old) were anes- thetized under 1% to 2% isoflurane and placed on a heating pad maintained at 37°C. Respiratory and heart rates were monitoring continually. After intubation, ...
11
Ethanol suppression of peripheral blood mononuclear cell trafficking across brain endothelial cells in immunodeficiency virus infection
... immune cell and virus trafficking or may result from interactions between ethanol and human immunodeficiency virus (HIV)-associated toxicity within the ...increased trafficking played a role, we ...
12
Bone marrow cell trafficking following intravenous administration
... marrow cell traf®cking at early time points, we cannot exclude a more complex speci®c homing process requiring prior cell processing in other tissues, or later changes in the cell surface, to ...
8
Laminins affect T cell trafficking and allograft fate
... T cell arrest on the endothelium is mediated by CCR7 and CXCR4 recognition of CCL21 and CXCL12, respectively, and these chemokines decorate the luminal surface of the ...T cell integrins that allow for the ...
16
Novel insight into stem cell trafficking in dystrophic muscles
... Stem cells were labeled with 250 µ g/mL nanoparticles of Fe 3 O 4 (Endorem) (Laboratorie Guerbet, Aulnay-Sous-Bois, France). Endorem, which is available in the form of an aqueous colloid, is a commercially available ...
9
Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency
... Cells were seeded on 24-well plates (10 5 cells/well) and cultured overnight to ~70% con fl uency. To quantify siRNA internalization, siRNA-polyplexes containing Cy3-labelled siRNA (Termo fi sher Sci- enti fi c, UK) ...
6
Stem cell transplantation impairs dendritic cell trafficking and herpesvirus immunity
... immune cell numbers are restored at 3 weeks after BMT (31) and T lymphocyte regeneration in the thymus (19) and reconstitution in the lung and spleen are com- plete at 5 weeks (32) in syngeneic BMT ...immune ...
17
Chemokine signaling in development and disease
... It has long been noted that certain types of cancer cells metastasize to specific sites in the body (Paget, 1889). For example, human breast cancers commonly metastasize to bone marrow, lung, liver and brain (Nguyen et ...
7
Diverse Roles For T-Bet In The Immune Response To Toxoplasma Gondii
... T cell trafficking and limit ...2002), cell cycle (Chang et ...T cell phenotype and/or migration remain unclear but may provide opportunities to target different functions of this ...
161
Understanding the impact of HIV-1 genetic diversity on the function of Nef and its role in SERINC5 antagonism
... host cell trafficking machinery and alters the molecular architecture of infected cells ...of cell surface proteins changes in its presence or ...of cell surface proteins is astounding, with ...
239
Corruption of Human Follicular B-Lymphocyte Trafficking by a B-Cell Superantigen
... Protein A (SpA) of Staphylococcus aureus is known to target the paratope of immunoglobulins expressing V H 3 genes, and to delete marginal zone B cells and B-1a in vivo. We have discovered that SpA endows S. aureus with ...
11
Pre Clinical Efficacy and Safety Evaluation of Human Amniotic Fluid Derived Stem Cell Injection in a Mouse Model of Urinary Incontinence
... T cell marker (CD8). For injected human cell trafficking and analysis of migration to target organs, human nuclear specific antibody (HuNu) was ...
10
Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase
... In this study, we generated transgenic mice expressing BACE1-YFP, and for the first time, visualized BACE1 dy- namic axonal transport in situ within the mossy fibers of the hippocampus by multiphoton microscopy. ...
18
The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells
... endogenous p40 and largely co-distributed with the p40 subunit by immunostaining (Figures S2A–S2F). The p35 subunit dis- played a consistent overlap with VAMP7 in the Golgi and in peripheral vesicles, whereas ...
14
The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
... the cell has important implications not only for their fate but also for their impact on biological ...a cell response has been ...of cell mechanisms that may be perturbed by cell–NP ...
14
Microtubule based localization of a synaptic calcium signaling complex is required for left right neuronal asymmetry in C elegans
... Fig. 5. The kinesin motor unc-104/kif1a is required for the localization of TIR-1, UNC-43 and NSY-1 in the AWC axons. (A,B) Localization of TIR-1::GFP in AWC neurons of wild-type (A) and unc-104(e1265) (B). (C) The ...
10
Vesicular traffic at the cell membrane regulates oocyte meiotic arrest
... the cell membrane following GRK phosphorylation and arrestin binding (Moore et ...the cell membrane to maintain meiotic ...vesicular trafficking at the cell membrane in maintaining meiotic ...
9