Cells of the tumour microenvironment
The role of mesenchymal stem cells in the tumour microenvironment
... The data from analyses performed in this chapter highlight the highly responsive and conditional nature of MSCs, demonstrating that exposure to the secretome of cancer cells and cancer-‐associated myofibroblasts ...
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Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy
... various tumour types [ 182 ...multiple tumour types (breast, lung, colon, melanoma, GBM, and prostate) [ 183 ...deficient cells show increased sensitivity to metabolic stress and were predictive of ...
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Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells : Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells
... promoting tumour development and recur- rence in cancer, and is required to maintain stemness in OC ...CR cells, a flux through acetyl-CoA may regulate primarily de novo FA synthesis, FAβO and subsequent ...
18
Adrenomedullin and tumour microenvironment
... in tumour progression is becoming more relevant with recent ...the tumour cells but also by numerous stromal cells including macrophages, mast cells, endothelial cells, and ...
15
The hypoxic tumour microenvironment
... cancer cells and provide them with building blocks 36–39 ...enhancing tumour growth in murine mammary cancer models 40 ...cancer cells 41 ...reduced tumour resilience and metastatic potential, ...
13
Adapting Immunotherapy to the Tumour Microenvironment
... • Engineer CAR-T cells to synthesise arginine precursors. Strong in vivo efficacy data: enhanced proliferation, increased anti-tumour activity, prolonged survival (publication – PMID:32573723, patent ...
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Understanding the Role of the Solid Tumour Microenvironment in Brain Tumour Progression
... of cells. To track cells it is necessary to compare images taken at different time points and identify which cells are the ...neighbouring cells. The ability to track individual cells ...
210
The role of microvesicles in EMT and tumour microenvironment
... of cells. This strict limitation of cells can only be achieved through a well governed regulation of the cell ...for cells undergoing ...target cells in the G1/S phases of the cell ...cancer ...
225
The Role of microRNA-145 in the Tumour Microenvironment
... 1.6.7 miRNA therapies miRNA mimics and antimirs are being developed for the therapeutic treatment of diseases or and cancer. The development of this new class of drugs comes with several challenges to overcome in ...
304
Development and characterization of a microfluidic model of the tumour microenvironment
... the tumour microenvironment upon drug response, three well-established drugs were ...proliferating cells. Our results showed that DOX was most cytotoxic against cells located at the hydrogel ...
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Modelling and analysis of the tumour microenvironment of colorectal cancer
... We have introduced a novel method for analysing multiplex image data such as the TIS image data in Chapter 3. It is dierent from previously presented methods in that it considers the samples at cell rather than at pixel ...
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Role of the Hedgehog pathway in the pancreatic tumour microenvironment
... of tumour [Olive et ...cancer cells) reduced the survival rate of mice with tumour and was associated with an undifferentiated aggressive tumour ...the tumour mass was reduced in these ...
358
Functional Roles for Exosomal MicroRNAs in the Tumour Microenvironment
... The term extracellular vesicle encompasses exosomes, microsomes and apoptotic bodies [14,15] . Exosomes are 30 –100 nm in size and are formed from inward budding of the endosomal membrane [16] . This forms a ...
6
Immune profiling of the tumour microenvironment in prostate cancer
... PC3M cells were prepared in RPMI supplemented with full serum at 5 x 10 5 ...4 cells) were placed onto the underside of the filter (which was now the ...allow cells to attach to the ...Stained ...
186
Defining the pro-tumour impact of the evolving stromal microenvironment
... CAF1 cells in the tumour microenvironment, the effects of blocking C3a signalling were ...myeloid cells, at the transcript level, indicating this population alone should be impacted by ...
264
Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours
... immune cells besides macrophages, as well as stromal cells, endothelial cells, pericytes and the extracellular matrix ...study tumour-associated macrophages, particu- larly regarding their ...
21
IL-6 Activities in the Tumour Microenvironment. Part 1
... for tumour cell ...Th17 cells. The anti-tumour function of IL-6 is the promotion of anti-tumour ...in tumour tissue are negative prognostic marker for patients’ ...
8
The relationship between tumour budding, tumour microenvironment and survival in patients with primary operable colorectal cancer
... determining the future of the primary tumor. For example, the good outcome associated with a pronounced tumor inflammatory cell infiltrate may be due to the effective elimination of the tumor. In contrast, the poor ...
8
The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer
... selected. Tumour sections were scanned using a Hamamatsu Nano Zoomer (Welwyn Garden City, UK) at 20 magnification, and visualisation was carried out using the Slide path Digital Image Hub, version ...of ...
8
The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer
... Glasgow Microenvironment Score (GMS) 10,23 ...the tumour and ...active tumour cells remove metabolites needed by the regulatory T-cells from the microenvironment, causing them to ...
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