cellular FLICE inhibitory protein
Herpes Simplex Virus Type 1 (HSV-1)-Induced Apoptosis in Human Dendritic Cells as a Result of Downregulation of Cellular FLICE-Inhibitory Protein and Reduced Expression of HSV-1 Antiapoptotic Latency-Associated Transcript Sequences
... cleave cellular substrates, leading to the characteristic morphological and biochemical features of ...the cellular FLICE-inhibitory protein (c-FLIP) (3, ...the cellular ...
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Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells
... binding protein homologous protein-dependent death receptor 5 induction and ubiquitin/proteasome-mediated cellular FLICE-inhibitory protein down-regulation contribute to ...
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Hepatitis C Virus Core Protein Inhibits Tumor Necrosis Factor Alpha-Mediated Apoptosis by a Protective Effect Involving Cellular FLICE Inhibitory Protein
... adapter protein TNFR1-associated death domain protein (TRADD), which in turn recruits TNF receptor-associated factor 2, recep- tor-interacting protein, and Fas-associated death domain pro- tein ...
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Kaposi's sarcoma associated herpes virus encoded viral FLICE inhibitory protein activates transcription from HIV 1 Long Terminal Repeat via the classical NF κB pathway and functionally cooperates with Tat
... K13 protein contains two homologous copies of a Death Effector Domain (DED) that is also present in the prodomains of caspase 8 (also known as FLICE), caspase 10 and cellular FLICE ...
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Caspases: pharmacological manipulation of cell death
... Death domains are 80- to 100-residue-long motifs Nonstandard abbreviations used: BIR, baculoviral IAP repeat; CARD, caspase recruitment domain; c-FLIP, cellular FLICE-inhibitory protein;[r] ...
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Selective Inhibition of FLICE-like Inhibitory Protein (FLIP) Expression With Small Interfering RNA Oligonucleotides (siRNAs) Is Sufficient to Sensitize Tumor Cells for TRAIL-Induced Apoptosis
... regard, cellular FLICE- inhibitory protein (cFLIP) has been identified as a major cellular inhibitor of apoptosis induced by TRAIL-R1/2 and other death receptors ...
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Distinct activation mechanisms of NF κB regulator inhibitor of NF κB Kinase (IKK) by isoforms of the Cell Death Regulator Cellular FLICE like Inhibitory Protein (cFLIP)*
... cells was validated by immunoblotting. From five independent shRNAs used to silence each protein, two that yielded the most efficient knockdowns were chosen for the experiments. Targeted sequences for each gene ...
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Internal Ribosome Entry Site Regulates Translation of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein
... immunodetection the polyclonal anti-v-FLIP rabbit serum was diluted 1:250 and detected by a goat anti-rabbit horseradish peroxidase (HRPO) antibody (1:2,000; Harlan) and enhanced chemiluminescence (Amersham) and the ...
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Cells of the synovium in rheumatoid arthritis Synovial fibroblasts
... A major factor contributing to synovial growth is the resis- tance of RASF against apoptosis, which can be linked to distinct anti-apoptotic molecules such as FLICE inhibitory protein (FLIP) and ...
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FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling
... (FADD) protein, receptor-interacting protein (RIP1), caspase-8 and tumor necrosis factor receptor (TNFR)-associated death domain (TRADD) protein, all traditionally associated with death receptor ...
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Integrated microarray and multiplex cytokine analyses of Kaposi's Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells
... responses, cellular stress, apoptosis and angiogen- esis ...K13 protein is one of the few proteins to be expressed in latently-infected spindle ...viral FLICE inhibitory protein ...
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Deletion of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein, vFLIP, from the Viral Genome Compromises the Activation of STAT1-Responsive Cellular Genes and Spindle Cell Formation in Endothelial Cells
... Furthermore, the NF- B-dependent functions of vFLIP ex- tend toward blocking KSHV lytic reactivation and virus pro- duction (72), most probably by inhibiting the replication tran- scription activator (RTA) promoter’s ...
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In-vitro physiological activities of peptides derived from underutilised Australian fish species
... Australian underutilised fish species may serve as a potential source of valuable proteins and potent bioactive peptides. This novel research is the first to investigate the effects of storage-processing conditions and ...
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The Cellular Protein La Functions in Enhancement of Virus Release through Lipid Rafts Facilitated by Murine Leukemia Virus Glycosylated Gag
... Flag-NA14 protein showed sporadic localized signals in the cytoplasm as well as the con- densed signals at perinuclear regions, but in cotransfections with HA-gg88, colocalization with Flag-NA14 was not observed ...
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The design of a new truncated and engineered alpha1-antitrypsin based on theoretical studies: an antiprotease therapeutics for pulmonary diseases
... Then, protein length from N-terminal was reduced to produce a smaller molecule which has the same and even higher inhibitory activity as the native ...Elastase Inhibitory Concentration ...
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Almost Periodic Solutions for Shunting Inhibitory Cellular Neural Networks with Time-varying and Distributed Delays
... Abstract. In this paper, shunting inhibitory cellular neural networks (SICNNs) with time- varying and distributed delays are considered. Without assuming the global Lipschitz condi- tions of activation ...
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Polymyxin B Alleviates Angiotensin II Induced Stress Fiber Formation and Cellular Hypertrophy
... Cellular hypertrophy was measured from H9c2 cells treated with Ang II (0.3 µM) for 4 consecutive days. Cells were seeded at a density of 3 × 10 4 cells per 35-mm dish of 6-well plates and cultured for 24 h in DMEM ...
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Modulation of expression and cellular distribution of p21 by macrophage migration inhibitory factor
... migration inhibitory factor (MIF) is an important contributor to normal cell division as well as oncogene-induced malignant transformation and tumor- igenesis ...p53 protein expression as measured by West- ...
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The cellular transcription factor SP1 and an unknown cellular protein are required to mediate Rep protein activation of the adeno-associated virus p19 promoter.
... CArG-140. The third element which appeared to have a strong effect on p19 promoter activity was a CArG-like site at position 2 140. This element was found to interact with a pro- tein that was present in crude HeLa cell ...
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The Epstein Barr virus EBNA1 protein modulates the alternative splicing of cellular genes
... to cellular RNA is either transitory or of low ...to cellular RNAs would likely sequester the protein away from its main role in replication and segregation of the EBV episome during latency, and ...
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