Cellular transformation
The role and mechanism of fibroblast growth factor receptor 2 in cellular transformation
... caused transformation of NIH 3T3 fibroblasts ...growth transformation (40, ...in cellular transformation and oncogenesis is not known, and may reflect cellular genetic context ...
137
Analysis of AP-1 function in cellular transformation pathways.
... Since either of the two transdominant mutants used in this study can function as a general inhibitor of AP-1, we next analyzed all known chicken AP-1 components was c-fos, fra-2, c-jun, [r] ...
9
Cellular transformation by subgenomic feline sarcoma virus DNA.
... MvlLu cells nonproductively transformed by STFeSV T61-1 cells column 1, NIH/3T3 cells transformed by transfection with untreated T61-1 DNA T227 cells column 2 and NIH/3T3 cells transform[r] ...
6
Cellular transformation by adenovirus type 5 is influenced by the viral DNA polymerase.
... We have shown that the E2B mutant ts36 15, 35, 36, 41 carries a single mutation specific to the viral DNA polymerase gene and that this lesion is responsible for both a defect in viral D[r] ...
5
Claudin 1 regulates cellular transformation and metastatic behavior in colon cancer
... static lesions. Nuclear localization of several cell junction proteins (β-catenin, ZO-1, ZO-2) is known to be correlated with oncogenic transformation and cell proliferation (36, 37). β-Catenin, a component of ...
13
Cellular Transformation of Mouse Embryo Fibroblasts in the Absence of Activator E2Fs
... The E2F family of transcription factors, broadly divided into activator and repressor E2Fs, regulates cell cycle genes. Current models indicate that activator E2Fs are necessary for cell cycle progression and ...
10
Regulation of adenovirus and cellular gene expression and of cellular transformation by the E1B-encoded 175-amino-acid protein.
... These differences may be explained as follows: i the expression of additional viral or cellular genes or both during a virus infection could diminish the role of the E1B 175R protein in [r] ...
10
Basolateral maturation of retroviruses in polarized epithelial cells.
... Because retroviruses establish persistent, nonlytic infections of epithelial cultures which can be passaged for extended periods without apparent cellular transformation or loss of polar[r] ...
9
Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.
... SV40-mediated cellular transformation is firmly estab- lished (16, 23, 52, 56, 59, 73, 74), although the functional consequences of this interaction are not fully understood and are still a matter of debate ...
9
SIRT1-mediated downregulation of p27 Kip1 is essential for overcoming contact inhibition of Kaposi’s sarcoma-associated herpesvirus transformed cells
... induced cellular transformation and ...induced cellular transformation and tumorigenesis by regulating cell proliferation, survival and metabolic pathways [6, 7] while vCyclin (ORF72) promotes ...
14
Role of gag sequence in the biochemical properties and transforming activity of the avian sarcoma virus UR2-encoded gag-ros fusion protein.
... Membrane association of the transforming protein of avian sarcoma virus UR2 and mutants temperature sensitive for cellular transformation and protein kinase activity.. Van der Eb.[r] ...
13
Growth in Agarose of Human Cells Infected with Cytomegalovirus
... If cytopathic effect does occur but virus replication and cell injury proceed slowly, the potential to induce cellular transformation might be recognized before cytolysis by the appearan[r] ...
6
Cellular localization of the transforming protein of wild-type and temperature-sensitive Fujinami sarcoma virus.
... In cells infected by mutants of FSV temperature sensitive for cellular transformation, most of the P140 is particulate at the permissive temperature, whereas most is soluble at the nonpe[r] ...
9
Infection of Primary Human Monocytes by Epstein-Barr Virus
... their cellular membrane, thus making it hard to detect gp350 by flow cytometric ...cell transformation, is readily detectable in the first 24 h of B-cell infection, and reaches maximal levels before EBNA-1 ...
8
The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.
... In this study, an infectious molecular clone of HTLV-2 was used to investigate the role of Tax in HTLV-mediated trans- formation of primary human T lymphocytes. The tax gene product clearly has oncogenic potential when ...
9
Stat proteins and oncogenesis
... Cellular transformation by activated Stat3 and its rel- atives undoubtedly occurs through the transcription- al regulation of specific genes. Many Stat3 target genes are known, including those encoding the ...
5
Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples
... into two sub-pathways, in which one single nucleotide is repaired by short patch pathway, whereas 1-6 nucleotide(s) is/are incorporated during the repair process of long-patch repair mechanism [10] . At least 30% of ...
5
Temperature-Sensitive Mutants of Fujinami Sarcoma Virus: Tumorigenicity and Reversible Phosphorylation of the Transforming p140 Protein
... To determine whether synthesis and phosphorylation of the p140 FSV protein are necessary for the maintenance of cellular transformation, we have isolated several spontaneous and chemical[r] ...
13
Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells.
... However, the formation of a complete MT/cellular protein complex and the activation of tyrosine kinase are not sufficient to cause transformation, since the transformation-defective muta[r] ...
7
Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq
... malignant transformation is not inevitable, because they are much less toxic and could be applied topically rather than ...malignant transformation and, if so, b) the use of oncolytic viruses known to ...
16