CF airway epithelial cells
Relation of exaggerated cytokine responses of CF airway epithelial cells to PAO1 adherence
... phenotype airway epithelial cells in culture respond to ...the CF cells, we compared the inflammatory response of matched pairs of CF and non CF airway ...
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Small molecule correctors of defective ΔF508 CFTR cellular processing identified by high throughput screening
... of CF that corrects the underlying ...wrong cells or losing physiological CFTR regulation, as might occur with gene therapy or activation of alternative chloride ...human CF airway ...
9
Activation of chloride transport in CF airway epithelial cell lines and primary CF nasal epithelial cells by S-nitrosoglutathione
... cultured CF airway epithelial cells ...native cells taken from CF patients or primary cell cul- tures has not yet been investigated; and pharmacological evidence that the Cl - ...
9
Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
... infected CF airways (2) accompanied by the production of high titers of specific Ab’s, ...the CF lung. Most hypotheses have focused on bacterial infection of CF airway epithelia, mediated by ...
10
cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia
... human airway epithelial cells bathed in a HCO3-/CO2-buffered, Cl(-)- free ...across airway epithelium, and suggest that HCO3- leaves the cell across the apical membrane via conductive ...
7
The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa
... the CF het- erozygous ...in epithelial cells as a monomer or a ...in CF, partial defects or dysfunction in the CF heterozygous carrier have been ...the CF carrier does not ...
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Acidic pH increases airway surface liquid viscosity in cystic fibrosis
... This study has advantages and limitations. This study has sev- eral advantages. First, by studying newborn piglets and their cultured epithelia, we were able to exclude confounding factors that might alter viscosity. ...
14
Cyclic adenosine monophosphate dependent kinase in cystic fibrosis tracheal epithelium
... cultured airway epithelial cells, including CF human tracheal epithelial ...from CF human tracheal epithelial cells has essentially the same Vmax ...
5
ajplung.00449.2019.pdf
... in CF airway ...with CF exhibited enhanced ATP hydrolysis rates relative to controls ...from airway epithelial and/or inflammatory cells in CF airways in vivo also ...
10
Liquid hyper-absorption as a cause of increased DTPA clearance in the cystic fibrosis airway
... the airway epithelium that accurately depicts electrophysi- ology and CF pathophysiology ...HBE cells were isolated from excess airway tissue dissected from lungs removed for ...the ...
10
rcmb.2007-0177oc.pdf
... viable cells) and 4 mM ethidium homodimer-1 (EthD-1; this dye is excluded by the intact plasma membrane of live cells, whereas it enters cells with damaged membranes and, upon binding to nucleic ...
12
Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens
... that airway epithelial cells might also be a source of Th2 ...that epithelial production of IL-25, thymic stromal lym- phopoietin (TSLP), and/or IL-33 might drive Th2 responses (par- ticularly ...
9
Rhinovirus C targets ciliated airway epithelial cells
... HeLa cells with CDHR3 rendered the cells permissive for RV-C binding and replication ...ciliated cells. Notably, RV-C does not infect secretory cells, which can be overrepre- sented in ...
11
Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells
... were then rinsed with PBS. Cells were stimulated for 2 h with the appropriate LSM NPs concentrations (0– 500 μg/ml) prepared in PBS. Cell lysing was prepared by the Peirce RIPA cell lysate reagent, and the lysate ...
8
Role of Macrophages in Internalization and Early Clearance of Pseudomonas Aeruginosa from the Mouse Lung
... This study was undertaken to investigate the role of AMs in the early clearance and bacterial internalization of P. aeruginosa in an acute model of pulmonary infection. Preliminary studies from our laboratory showed that ...
6
Antiinflammatory effects of bromodomain and extraterminal domain inhibition in cystic fibrosis lung inflammation
... with CF often suffer from inflammatory lung diseases caused by chronic bacterial coloniza- ...in CF epithelial cells is believed to be in part responsible for the recruitment of large numbers ...
11
Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells
... corneal epithelial cells [11], just like it was in the airway epithelial ...in airway epi- thelium is consistent with previous study reported by Schauber et ...nasal epithelial ...
6
Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma
... effector cells in initiating or perpetuating airway inflammation [23,24], respond by TSLP release to stimulation with TNF-α and IL-1β both in vitro and in vivo ...in cells with mutated mediators NFκB ...
8
Regional heterogeneity in response of airway epithelial cells to cigarette smoke
... from airway lumen and COPD se- verity was investigated by analyzing lung tissue from patients with all clinical stages of COPD [9], revealing that small-airway obstruction associated with COPD is related to ...
11
Migrating leukocytes are the source of Peroxiredoxin V during inflammation in the airways
... lung epithelial cells, and immune cells in vivo and in ...these cells or whether the increased level of PRXV was induced by leu- kocyte ...the airway and alveolar epithelial ...
12