Chemokine receptor
Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection
... and chemokine synthesis ...selected chemokine receptors and their chemokine lig- ands during HSV infection of mouse corneal and TG tis- ...type chemokine receptors and their ligands persists ...
12
Chemokine (C-X-C Motif) Receptor 4 and Atypical Chemokine Receptor 3 Regulate Vascular α1-Adrenergic Receptor Function
... motif) receptor (CXCR) 4 and atypical chemokine receptor (ACKR) 3 ligands have been reported to mod- ulate cardiovascular function in various disease ...CXC chemokine ligand 12 (CXCL12), or ...
13
Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes
... CC-chemokine receptor genes (CCR3, CCR2, CCR5 and CCRL2) on chromosome 3p21, and a cluster of three CC-chemokine genes [MPIF-1 (CCL23), PARC (CCL18) and MIP-1a (CCL3)] on chromosome ...of ...
19
The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor
... potential chemokine recep- tors: UL33, UL78, US27, and ...alter chemokine levels in the supernatant of infected cells, possibly by a sequestration mechanism (12), potentially affecting immune responses, ...
6
Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis
... er chemokine receptor (CXCR3) which was readily detected by flow cytom etry and im m unocytochem istry as shown in chapter ...CCR2 receptor targ etin g it to degradation by th e proteasom e rath e ...
330
Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms
... The chemokine receptor CXCR4 is a seven transmembrane G-protein coupled ...the receptor by its natural ligand CXCL12 (SDF-1, stromal cell derived factor 1) leads to the proliferation of cells and ...
13
Regulation of pulmonary fibrosis by chemokine receptor CXCR3
... CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-γ–inducible C-X-C chemokines MIG/CXCL9, IP-10/ CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on activated immune cells and proliferating ...
10
Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients
... predictors (adjusted R 2 = 0.64, F(8,12) = 5.58, P = 0.004). Whether surface expression of these selected candidates is linked to disease progression and disease aggressiveness was ascertained by means of the D50 model ...
5
Chemokine Ligand 5 (CCL5) and chemokine receptor (CCR5) genetic variants and prostate cancer risk among men of African Descent:a case-control study
... with cancer or inflammatory/immune response related diseases; (2) commonly studied loci; (3) marked dispar- ities in genotype frequency comparing men of African descent to their Caucasian counterparts (i.e., ±10% ...
11
Molecular Imaging of Chemokine Receptor CXCR4
... CXCR4 was found to be expressed by many different types of human cancers and its ex- pression has been correlated with tumor aggressiveness, poor prognosis and resistance to chemotherapy. CXCR4 was also shown to ...
9
Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors - a Triple Tracer Comparative Approach
... Figure 3. Concordance of immunohistochemistry and non-invasive receptor-directed PET imaging in a patient with pancreatic neuroendocrine tumor (NET; patient #3; Ki67: 85%). Display of transaxial PET (left) and ...
10
Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma
... the chemokine receptor CCR5 and is expected to reduce surface levels similar to the way in which SDF-1-KDEL removes CXCR4 from the cell ...other chemokine receptors ...
10
CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab secreting cells
... one chemokine receptor (CCR10) for the homeostatic localization of two very distinct leuko- cyte subsets (memory T cells and IgA PCs) is intrigu- ...epithelial chemokine MIP-3 α /CCL20 (21, 22) ...
11
CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients
... of chemokine expression by the target tissue as well as the expression of the respective receptors on EPC [14–21] Molecular regulators that affect both leukocyte and EPC migration and activity are known and might ...
8
CCR9 in cancer: oncogenic role and therapeutic targeting
... of chemokine receptor 9 (CCR9) and its specific ligand chemokine ligand 25 (CCL25) have been elucidated, and, interestingly, a number of studies have demonstrated that CCR9 is a potential tumor ...
9
Complementary action of granulocyte macrophage colony stimulating factor and interleukin 17A induces interleukin 23, receptor activator of nuclear factor κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis
... CC chemokine ligand; CCR: CC chemokine receptor; CIA: Collagen-induced arthritis; CII: Type II collagen; Ct: Cycle threshold; CXCL: Chemokine (C-X-C motif) ligand; DC: Dendritic cell; EAE: ...
14
Aging, inflammation, stem cells, and bone healing
... 1 receptor; CXCR4: C-X-C chemokine receptor type 4; FGF: Fibroblast growth factor; FIZZ1: Found in inflammatory zone protein; GM-CSF: Granulocyte macrophage colony-stimulating factor; HLA-DR: Human ...
7
Interleukin 10 producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis
... C-X-C chemokine receptor type 3; CXCR5: C- X-C chemokine receptor type 5; DAS28: Disease Activity Score in 28 joints; Egr2: Early growth response gene 2; ELISA: Enzyme-linked immunosorbent ...
11
Pulsed high dose dexamethasone modulates Th1 /Th2 chemokine imbalance in immune thrombocytopenia
... Glucocorticoid therapy is still the primary choice for treatment of ITP. Due to the poor long-term sustainabil- ity and possible adverse effects of long-term administra- tion of corticosteroids [19], recent reports ...
8
Chemokine blockade: a new era in the treatment of rheumatoid arthritis?
... (homeostatic) chemokine receptor knockout mouse model was shown to lead to perinatal death, namely the CXC chemokine receptor (CXCR)4 knockout mouse ...CXC chemokine ligand ...
5