Chemokine receptor 4
The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors
... cells. Chemokine- induced signaling cascades regulate leukocyte migration, hematopoietic stem cell proliferation, and cell adhesion to extracellular matrix molecules [12, ...motif chemokine ligand 12 ...
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68Ga-Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression in Glioblastoma
... Chemokine receptor-4 (CXCR4) is a member of the G-protein-coupled chemokine receptor family ...The receptor plays an important role in a variety of physiologic processes that ...
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CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells
... a chemokine to its receptor, a transient dose-dependent increase in intracellular calcium concentration occurs as an essential component of the signal transduction ...CXCR4-specific chemokine SDF-1␣ ...
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Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists
... All compounds in Table 1 were tested as human CCR4 antagonists in vitro. Antagonist potency was determined by a [ 35 S]-GTPS radioligand competition functional assay using recombinant CCR4-expressing CHO cell membranes ...
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Initial Assessment of the Role of CXC Chemokine Receptor 4 after Polytrauma
... AMD3100 is a tight binding, slowly reversible antagonist of CXCR4, which does not induce receptor internalization (33,46). However, the affinity of AMD3100 for CXCR4 (K i [equilibrium inhibition constant]: 100–650 ...
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Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors - a Triple Tracer Comparative Approach
... robust receptor expression in G3 NET, targeting of CXCR4 emerges as a promising new therapeutic approach for these ...sufficient receptor expression early in the course of treatment is essential in order ...
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Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
... CC-chemokine receptor 2; CCR5: CC- Chemokine receptor 5; CD11b: Cluster of differentiation 11B; CXCR3: CXC-chemokine receptor 3; CXCR4: CXC-chemokine receptor ...
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Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia
... ceptors, chemokine receptor 4 (CXCR4) or chemokine receptor 7 (CXCR7) modulates cell adhesion, migration, proliferation, survival, and differentiation ...this chemokine mediates ...
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Are CD4+CD25 Foxp3+cells in untreated new onset lupus patients regulatory T cells?
... CD127, chemokine receptor 4 [CCR4], glucocorticoid-induced tumor necrosis factor receptor [GITR], and cytotoxic T lymphocyte- associated antigen 4 [CTLA-4]) and intracellular ...
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Th17 and Th22 cells in psoriatic arthritis and psoriasis
... Whereas recent evidence implicates interleukin 22 (IL- 22) in the pathogenesis of skin disease in Ps [6,7], PsA has been postulated to more likely involve IL-17 [8,9]. Both cy- tokines can be made by the T helper 17 ...
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Cancer metastasis: enactment of the script for human reproductive drama
... motif chemokine receptor 4/C–X–C Motif Chemokine Ligand 12; DNMT/TET: DNA methyltransferase/ten-eleven translocation methylcytosine dioxygenase; EMT/MET: epithelial–mesenchymal ...
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CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients
... of chemokine expression by the target tissue as well as the expression of the respective receptors on EPC [14–21] Molecular regulators that affect both leukocyte and EPC migration and activity are known and might ...
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Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes
... CC-chemokine receptor genes (CCR3, CCR2, CCR5 and CCRL2) on chromosome 3p21, and a cluster of three CC-chemokine genes [MPIF-1 (CCL23), PARC (CCL18) and MIP-1a (CCL3)] on chromosome ...exon 4 ...
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CXCR4+ cells are increased in lung tissue of patients with idiopathic pulmonary fibrosis
... blocks, 4 μm thick paraffin sections were immunohistochemi- cally stained for CXCR4 (dilution 1:500, clone UMB2, Cat# ab124824, Abcam, UK), CXCL12 (dilution, 1:500, clone EPR1216, Cat# ab155090, Abcam, UK), E- ...
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Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype.
... Our results indicate that primary HIV-1 isolates with distinct biological phenotypes utilize chemokine receptors for entry into target cells according to a characteristic pattern. The abil- ity of rapid/high (SI) ...
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Interleukin 17A promotes functional activation of systemic sclerosis patient derived dermal vascular smooth muscle cells by extracellular regulated protein kinases signalling pathway
... Microangiopathy is one of the earliest clinical manifes- tations of patients with SSc, which exists throughout the course of the disease [4]. Raynaud’s phenomenon, digital ulcers, pulmonary arterial hypertension ...
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Central memory CD8+ T lymphocytes mediate lung allograft acceptance
... Memory T lymphocytes are commonly viewed as a major barrier for long-term survival of organ allografts and are thought to accelerate rejection responses due to their rapid infiltration into allografts, low threshold for ...
15
Regulatory T cells in multiple sclerosis and myasthenia gravis
... A recent analysis of over 14,000 MS patients using ImmunoChip genotyping found abnormalities in genes in- volved in Treg IL-2 signaling, CD25, and CD127 [55]. While CD127 is expressed highly on Teff, but minimally on ...
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Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma
... IL-6 secreted by TAMs is an important factor involved in the occurrence and development of tumors [29, 30]. It is relatively clear that IL-6 mediates EMT mainly via the IL-6/STAT3 pathway. In this process, IL-6 binds to ...
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Role of dendritic cells in the induction of regulatory T cells
... gen 4 (CTLA4) and lose their ability to produce IFN-g, IL-2, IL-4 and subsequently differentiate into Tr1 cells ...lectin receptor SIGNR-1, resulting in preferential pro- duction of IL-10 but not ...
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