chemotherapeutic efficacy
Prediction of neoadjuvant chemotherapeutic efficacy in patients with locally advanced gastric cancer by serum IgG glycomics profiling
... In order to accurately predict the efficacy of NACT in gastric cancer, we attempted to build a predictive model including clinical traits and the directly meas- ured IgG glycans. First, we built a clinical-model ...
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Fucoxanthin enhances 5-FU chemotherapeutic efficacy in colorectal cancer cells by affecting MMP-9 invasive proteins
... traditional chemotherapeutic efficacy and is a highly undesirable therapeutic problem which poses particular challenges in the case of colorectal ...
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CHEMOTHERAPEUTIC EFFICACY OF TRIDHAM AND 1,2,3,4,6 PENTA O GALLOYL β DGLUCOSE ON ANTIOXIDANTS STATUS AND TUMOR MARKERS IN EXPERIMENTAL MAMMARY CARCINOMA IN SPRAGUE DAWLEY RATS
... Vol 9, Issue 5, 2016 Online 2455 3891 Print 0974 2441 CHEMOTHERAPEUTIC EFFICACY OF TRIDHAM AND 1,2,3,4,6 PENTA O GALLOYL ? D GLUCOSE ON ANTIOXIDANTS STATUS AND TUMOUR MARKERS IN EXPERIMENTAL MAMMARY C[.] ...
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Original Article Serum SQSTM1 is a potential predictor for chemotherapeutic efficacy against non-small cell lung cancer
... two chemotherapy cycles. The average of serum SQSTM1 in 80 NSCLC patients de- creased from 191.08 ng/L (19.93-387.04 ng/L) to 124.91 ng/L (14.84-300.98 ng/L), the SD changed from 68.34 ng/L to 59.96 ng/L. There was ...
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Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy
... Exercise enhances chemotherapeutic efficacy Exercise has been described as both pro- and anti- tumor growth in studies using mouse models [8, 15, 16]. Our data demonstrating vascular normalization in PDAC- ...
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Improved chemotherapeutic efficacy of injectable chrysin encapsulated by copolymer nanoparticles
... In this study, we demonstrate that mPEG-PCL in NP form can encapsulate chrysin, improve its bioavailability, and thus, its chemotherapeutic efficacy. In particular, the chrysin-NPs produced were injectable ...
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Anticancer drug-loaded multifunctional nanoparticles to enhance the chemotherapeutic efficacy in lung cancer metastasis
... Prior to the cancer cell implantation, A-549 cells were cultured in F12K media containing 10% FBS and 1% penicillin-streptomycin antibiotic mixture. The orthotopic tumor models were developed by anesthetizing the mice ...
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PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma
... To corroborate our in vitro findings, we used a transplant- able murine EAC tumor model to investigate the antitumor activity, if any, of tea-NPs used alone and in combination with CDDP. Tea-NPs in combination with a low ...
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<p>Enhanced Chemotherapeutic Efficacy of PLGA-Encapsulated Epigallocatechin Gallate (EGCG) Against Human Lung Cancer</p>
... EGCG, (-)-epigallocatechin gallate; PLGA, poly(lactic-co- glycolic acid); SD, standard deviation; NPs, nanoparticles; NR, Nile Red; EE, encapsulation ef fi ciency; DL, drug loading; PDX, [r] ...
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Curcumin potentiates the chemotherapeutic efficacy of Cisplatin in 7,12 dimethylbenzanthracene induced oral cancer in Syrian golden hamsters
... as chemotherapeutic effect of curcumin in oral SCC, some delving into the intrinsic molecular mechanisms involved with the ...the chemotherapeutic potential of curcumin was studied simultaneously in an in ...
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Inhibition of PKCδ reduces cisplatin induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer
... mechanism of cisplatin-induced nephrotoxicity remains unclear, and renoprotective approaches during cisplatin-based chemotherapy are lacking. Here we have identified PKCd as a critical regulator of cisplatin ...
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Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model
... Although metastases were not found in the donor GC patient (TNM Staging II, T3N1M0) by the time when surgical resection was performed, the tumor did metastasize in the PDX model GA0087, suggesting that additional host ...
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Nano formulation of Ethambutol with multifunctional Graphene Oxide and magnetic nanoparticles retains Its anti tubercular activity with prospects of improving chemotherapeutic efficacy
... Potentiating current therapy by altering the delivery and administration routes of these drugs is garnering attention in the international scientific communities. Nanomedicine is a rapidly advancing field in biomedical ...
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Construing the Biochemical and Molecular Mechanism Underlying the In Vivo and In Vitro Chemotherapeutic Efficacy of Ruthenium-Baicalein Complex in Colon Cancer
... the chemotherapeutic potential of the ruthenium baicalein complex by activating p-53 dependent intrinsic apoptosis and modulating the AKT/mTOR and WNT/β- catenin ...potential chemotherapeutic activity ...
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Comparative study of adjuvant chemotherapeutic efficacy of docetaxel plus cyclophosphamide and doxorubicin plus cyclophosphamide in female breast cancer
... This study was designed to compare TC and AC as adjuvant chemotherapy treatment for female breast cancer patients on the basis of the presence or absence of 1–4 grade anemia (includin[r] ...
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CHEMOTHERAPEUTIC EFFICACY OF WITHAFERIN A IN EXPERIMENTAL HEPATOCELLULAR CARCINOMA
... detection and management of liver cancer. In view above, we tried to demonstrate dysregulated and reprogrammed cancer metabolism followed by clinical relevance of the metabolic enzymes, such as Glycolytic enzymes, ...
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The over-expression of survivin enhances the chemotherapeutic efficacy of YM155 in human hepatocellular carcinoma
... Survivin (BIRC5) is a member of the inhibitor-of- apoptosis proteins (IAPs) family that is overexpressed in most of human tumors but not in normal tissues [12]. YM155, a survivin suppressant, has been tested as a single ...
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Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study
... Methods: Experiments were performed on 40 eight-week-old female Swiss albino mice divided into three experimental groups and one control group. Assessment of efficacy was based on a suite of parasitologic and ...
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Enhanced solubility and functionality of valrubicin (AD-32) against cancer cells upon encapsulation into biocompatible nanoparticles
... the chemotherapeutic efficacy of AD-32 upon encapsulation in biocompatible nanoparticles may be markedly enhanced by the reduction (or elimination) of harmful side effects, due to selective tumor delivery ...
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Axitinib Targeted Cancer Stemlike Cells to Enhance Efficacy of Chemotherapeutic Drugs via Inhibiting the Drug Transport Function of ABCG2
... Stemlike cells have been isolated by their ability to efflux Hoechst 33342 dye and are called the side population (SP). We eval- uated the effect of axitinib on targeting cancer stemlike cells and enhancing the ...
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