Chimeric Antigen Receptor
CHIMERIC ANTIGEN RECEPTOR FOR CHRONIC LYMPHOCYTIC LEUKEMIA A REVIEW
... Chronic lymphocytic leukemia (CLL) cancer is a deadly one which affects the bone marrow from making it to produce more amounts of white blood cells in the humans [66,67,73]. The lymphocytes consist of natural killer ...
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Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells
... al. Chimeric antigen receptor T cells for sustained remissions in ...al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic ...
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Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells
... Receptor tyrosine-protein kinase ERBB2 (HER2) is a well-known immunotherapy target that is overexpressed in multiple adult and pediatric cancers [4–7], including approximately 40% of medulloblastoma. HER2 surface ...
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Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia
... priority. Chimeric antigen receptor-modified T cell (CAR-T) therapy, as one of the most promising targeted immunotherapies, has drawn extensive attention and resulted in multiple ...CD19, ...
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Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity
... cell receptor (TCR) or a chimeric antigen receptor (CAR, also called a T-body) recognizing an intact surface antigen preferentially expressed on the surface of malig- nant cells ...
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Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer
... mesothelin-specific chimeric antigen receptor T Cells to treat patients with pancreatic carcinoma metasta- ...Interestingly, antigen spreading was observed in the case report published by the ...
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<p>Advances Of Chimeric Antigen Receptor T Cell Therapy In Ovarian Cancer</p>
... Abstract: Ovarian cancer, as a common gynecological tumor, is currently recognized as the most lethal gynecological malignancy. In addition to conventional treatment methods such as surgery, radiotherapy and ...
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Critical factors in chimeric antigen receptor-modified T-cell (CAR-T) therapy for solid tumors
... of chimeric antigen receptor-modified T-cell (CAR-T) therapy for B-cell lymphocyte malignancies targeting CD19 places it in a rapidly growing field in cancer immunotherapy for both hematological and ...
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Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
... immunotherapy, chimeric antigen receptor-engineered T cells (CAR-T) therapy, a novel adoptive immune treatment, has also become more and more important in treating R/R ...without antigen ...
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Protein L: a novel reagent for the detection of Chimeric Antigen Receptor (CAR) expression by flow cytometry
... a chimeric antigen receptor (CAR) combines the beneficial effects of both antibody and T-cell mediated immune ...surface antigen fused to extracellular spacer and transmembrane domains ...
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Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
... cell receptor (TCR) (4) or a chimeric antigen receptor (CAR) (5) to target a known tumor ...tumor antigen linked to an intracellular domain with the signaling domains of CD3 and CD28 ...
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Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell
... Substantial experimental and clinical evidence indicates that the specificity of an antibody (Ab) predicts the reactivity of the chimeric antigen receptor (CAR) that is derived from it. For example, ...
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A quantitative method for measuring the transfection efficiency of CD19-directed chimeric antigen receptor in target cells
... mine the ratio of infected cells to total cells. In addition, an antibiotic-resistance gene used in a recombinant vector is another method of screening for infected cells or valid cells with removing the uninfected ...
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Chimeric antigen receptor–induced BCL11B suppression propagates NK like cell development
... cell receptor (TCR) (1–3) or, more recently, chimeric antigen receptor (CAR) engineer- ing has produced impressive clinical results ...genetic receptor transfer technologies have been ...
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A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing
... on osteoprogenitors, brain, peripheral nerves and skin melanocytes [5, 6]. Because of its high surface expression on tumor cells and low expression on normal tissues, GD2 has been a target for the development of ...
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Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies
... On the basis of CD3 as a clinically validated target, our approach using CAR-modified NK cells represents a complementary therapy approach to CAR T-cells with an emphasis on the short life span and cytotoxic effector ...
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Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance
... maturation antigen; CAR: Chimeric antigen receptor; CI: Confidence interval; CLL: Chronic lymphocytic leukemia; CR: Complete response; CRES: CAR T cell- related encephalopathy syndrome; ...
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Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy
... Chimeric antigen receptor-modified (CAR) T cells targeting CD19 (CART19) have shown therapeutical activities in CD19+ malignancies. However, the etiological nature of neurologic complications remains ...
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Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells
... 8. Porter DL, Hwang WT, Frey NV, Lacey SF, Shaw PA, Loren AW, Bagg A, Marcucci KT, Shen A, Gonzalez V, et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed ...
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Construction and Functional Characterization of a Fully Human Anti-mesothelin Chimeric Antigen Receptor (CAR) Expressing T Cell
... Chimeric antigen receptor (CAR) T cell therapy is considered as an encouraging approach for the treatment of hematological ...tumor-associated antigen (TAA) expressed in numerous types of ...
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