Cholestatic Liver Disease
Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease
... In summary, our study provides further evidence linking β-catenin signaling to deregulations of individual CYP450 isoforms, bile acid formation and therefore cholestatic liver disease. Our data ...
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Erythropoietic Protoporphyria: Initial Diagnosis With Cholestatic Liver Disease
... Hepatobiliary disease affects the minority of individuals with EPP and usually manifests in patients with an established diagnosis of ...with liver biopsy, which revealed dense, dark-brown pigment in ...
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Chronic Cholestatic Liver Disease With Associated Tubulointerstitial Nephropathy in Early Childhood
... of cholestatic liver disease and progressive tubulointerstitial nephritis, leading to renal death in early ...fibrosis; liver histology was characterized by portal fibrosis and bile duct ...
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Bone Mineral Content in Infants and Children With Chronic Cholestatic Liver Disease
... tent (BMC) status and serum vitamin D metabolite levels of infants and children with chronic cholestatic liver dis- ease.. To determine if severity of bone disease in these patients corr[r] ...
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Primary sclerosing cholangitis
... chronic cholestatic liver disease of unknown aetiology characterised by inflammation and fibrosis of the biliary ...the disease progresses to cirrhosis and liver ...bowel ...
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Zinc status in infants and children with cholestatic liver diseases and its effect on growth
... The study enrolled 55 infant and children (0.5–10 years) of both sex, with chronic cholestatic liver disease. Full demographic and clinical characteristics were re- ported. Anthropometric ...
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Jaundice revisited: recent advances in the diagnosis and treatment of inherited cholestatic liver diseases
... system. Cholestatic liver disease is one of the most common forms of liver disor- ders resulting from inherited or acquired liver ...the liver, and consequently cause elevated ...
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A case of severe osteomalacia caused by Tubulointerstitial nephritis with Fanconi syndrome in asymptomotic primary biliary cirrhosis
... chronic cholestatic liver disease, characterized by increased concentrations of serum IgM and the presence of circulating anti-mitochondrial ...
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Osteoporosis in Non Cholestatic Decompensated Chronic Liver Disease and Its co-relation with Vitamin D and Parathyroid Hormone Levels
... of liver transplantation, metabolic bone disease com- plicating CLD has become a major clinical ...After liver trans- plantation the combination of high dose corticosteroids and immobilization ...
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PRIMARY BILIARY CIRRHOSIS
... antibody, cholestatic liver disease, AMA-negative primary biliary cirrhosis and Overlap Syndromes were used as search words on search engines including Google Scholar, PubMed, iMediSearch, ...
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Stimulation of bile duct epithelial secretion by glybenclamide in normal and cholestatic rat liver
... liver disease. Chronic cholestasis leads not only to impaired liver function and cirrhosis, but to systemic complications such as vitamin de- ficiencies, bone disease, steatorrhea, and ...
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Biochemical Markers of In Vivo Hepatotoxicity
... The liver is the largest organ of the human body that performs multiplicity of vital metabolic functions ...the liver is located slightly beneath the diaphragm and anterior to the stomach ...A. Liver ...
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Hepatotoxicity of anabolic androgenic steroids in sport
... Elevated liver enzymes are typical for danazol and oxymetholone abuse ...the liver function and ASS induced hepatotoxicity based merely on the liver enzymes levels can be misleading and cause an ...
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CLOPIDOGREL–INDUCED CHOLESTASIS: A CASE REPORTAND REVIEW OF THE LITERATURE.
... The liver plays an indispensable role in the degradation and excretion of metabolic end- products of many drugs making it at a greater risk for chemical-induced ...induced liver injury ...vascular ...
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Ciprofloxacin Cardiotoxicity and Hepatotoxicity in Humans and Animals
... in liver of pregnant rats and their ...the liver of the fetuses showed fatty changes, haemolysis of the blood in sinusoidal spaces and severe dilatation of central vein with focal hemo- siderosis, necrosis ...
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Secondary sclerosing cholangitis in critically ill patients: current perspectives
... static disease affecting the intra- and/or extrahepatic biliary tree with inflammation and progres- sive stricture formation, which can lead to biliary ...of liver disease and no known pathologic ...
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Chlorpromazine induced perturbations of bile acids and free fatty acids in cholestatic liver injury prevented by the Chinese herbal compound Yin Chen Hao Tang
... chronic liver disease characterized as a consequence of disturbed hepatocellu- lar secretion of bile, impaired bile formation, and slow bile flow ...drug-induced liver injury and is usually ...
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Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis
... and liver cirrhosis, which are consid- ered false-positives) ...novel Cholestatic liver fibrosis is caused by obstruction of the biliary tract and is associated with early activation of portal ...
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PubMedCentral-PMC5505863.pdf
... drug-induced liver injury were based on adjudication by the DILIN Causality Committee using expert consensus ...the liver injury and the implicated agent was scored as definite (greater than 95% ...
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Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response
... Human cholestatic liver. Twelve examples of cholestatic liver injury (Supplemental Table 2) were ran- domly selected from the pathology ...each liver biopsy were reviewed prior to ...
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