Cholinergic neurons
Selective lesions of the cholinergic neurons within the posterior pedunculopontine do not alter operant learning or nicotine sensitization
... of cholinergic PPTg neurons has no effect on the continued performance of a drug self-administration task learnt prior to lesion surgery (Steidl et ...of cholinergic input from pPPTg to midbrain DA ...
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Peptone stimulates CCK releasing peptide secretion by activating intestinal submucosal cholinergic neurons
... of cholinergic pathways in the mediation of peptone induced CCK-RP secretion, atropine (100 m g/kg per hour) was ad- ministered intravenously to the donor rats 30 min before intestinal perfusion of 5% peptone as ...
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Intermittent vs Continuous Administration of Nerve Growth Factor to Injured Medial Septal Cholinergic Neurons in Rat Basal Forebrain
... (MS) neurons in rodents are deprived of their source of NGF following fimbria/ fornix (FF) lesions causing MS neuronal atrophy and loss of cholinergic markers ...MS neurons and their ...
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Stem cell derived basal forebrain cholinergic neurons from Alzheimer’s disease patients are more susceptible to cell death
... positive neurons (Figure 2A). Approxi- mately 66 ± 3% of these neurons expressed the cho- linergic neuron marker choline acetyltransferase (ChAT) (Figure 2B, C) as well as another cholinergic marker, ...
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Donepezil rescues the medial septum cholinergic neurons via nicotinic ACh receptor stimulation in olfactory bulbectomized mice
... on cholinergic neurodegeneration in OBX mouse medial ...linergic neurons. (a), cholinergic neurons were identified by ChAT immunostaining in sham (b), donepezil treated (1 mg/kg daily for 15 ...
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Mueller, Markus (2005): In vivo function of NGF/TrkA signaling in the cholinergic neurons of the murine basal forebrain. Dissertation, LMU München: Fakultät für Biologie
... Cholinergic neurons are also well known to modulate events related to ...correct cholinergic innervation of the ...cortical neurons selectively process information related to a given part of ...
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Function and mechanism of long non-coding RNA Gm21284 in the development of hippocampal cholinergic neurons
... into cholinergic neurogenesis after the projection fibers of cholinergic neurons in the basal forebrain are ...after cholinergic innervation [3, 4]. We estab- lished a model of ...
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Pallial origin of basal forebrain cholinergic neurons in the nucleus basalis of Meynert and horizontal limb of the diagonal band nucleus
... of cholinergic neurons in the mouse BF (Marin et ...the cholinergic system in the dorsal ST; however, neurons in the ventral ST and Tu are unaffected, possibly owing to their pallial origin ...
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Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator- and apolipoprotein E-conjugated liposomes to the hippocampus
... Abstract: β-Amyloid (Aβ)-targeting liposomes (LIP) with surface serotonin modulator (SM) and apolipoprotein E (ApoE) were utilized to facilitate the delivery of nerve growth factor (NGF) across the blood–brain barrier ...
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A simple differentiation protocol for generation of induced pluripotent stem cell-derived basal forebrain cholinergic neurons for Alzheimer’s disease and frontotemporal dementia disease modeling
... The cholinergic system, characterized by its use of the neurotransmitter acetylcholine, is one of the first to degenerate in Alzheimer’s disease and is also affected in frontotemporal ...forebrain ...
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Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
... brain cholinergic cells to axotomy based on the use of time-course analyses, multiple immunostainings and quantitative confocal ...that cholinergic cells do not respond to disconnection of their target, as ...
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iPSC-derived familial Alzheimer’s PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling
... At this point, the key questions are: how exactly does AD impair brain and neuronal insulin signaling and if neuronal insulin resistance is induced by AD pathology, is it a cell autonomous effect or secondary to altered ...
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Trans-Differentiation of Human Dental Pulp Stem Cells Into Cholinergic-Like Neurons Via Nerve Growth Factor
... of neurons and cytotoxicity declined due to the expression of the NGF, GDNF, and BDNF by the hDPSCs (Leong et ...into neurons but increased the lifespan of neurons and glia in the injury site and its ...
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Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease
... PPN cholinergic neurons. Bilateral lesioning of the cholinergic part of the PPN induced gait and postural deficits in nondopaminergic lesioned ...the cholinergic neurons of the PPN play ...
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The Role of Cholinergic Signaling in Cardiac Function
... recently, cholinergic control has been highlighted for its potential as an alternative ...where cholinergic enzymes are knocked down, show poor cardiovascular health, and have exaggerated cardiovascular ...
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Adenosine Inhibits the Excitatory Synaptic Inputs to Basal Forebrain Cholinergic, GABAergic, and Parvalbumin Neurons in Mice
... local neurons in the slice or due to spontaneous, action potential-independent release from synaptic ...glutamatergic neurons as well as directly inhibiting trans- mitter release from presynaptic ...
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Pitx2 cholinergic interneurons are the source of C bouton synapses on brainstem motor neurons
... Pitx2+ neurons only in the caudal medulla around the central canal and in the caudal intermediate reticular nucleus (IRt), a percentage of which were found to be ...labelled cholinergic synapses within ...
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Irinotecan-Induced Gastrointestinal Dysfunction Is Associated with Enteric Neuropathy, but Increased Numbers of Cholinergic Myenteric Neurons
... ChAT-immunoreactive neurons and the density of cholinergic nerve fibers observed at Day 3 of IRI administration leading to increased secretion, whereas symptoms of chronic diarrhea at days 7, 14, and ...
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Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease
... the cholinergic neurons of the nucleus tegmenti pedunculopontine (PPTg), the rat equivalent of the human ...PPTg cholinergic neurons, similar to what is seen in the post-mortem brains of ...
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Basal Forebrain Cholinergic Deficits Reduce Glucose Metabolism and Function of Cholinergic and GABAergic Systems in the Cingulate Cortex
... forebrain cholinergic neuron degeneration are common features of Al- zheimer’s disease and have been correlated with memory ...of cholinergic basal forebrain neurons, the interaction between ...
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