Chondrocyte hypertrophy
Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy: implications for joint remodeling in AS
... Chondrocyte hypertrophy is induced by activation of the wnt pathway leading to intracellular beta-catenin ac- cumulation in chondrocytes [7, 8]. This promotes upreg- ulation of the runt-related ...
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SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice
... regulate chondrocyte hypertrophy, SIK3 might be localized and controlled by these signaling molecules during the progression of chondrocyte ...affect chondrocyte differentiation, as ...
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Inhibitory function of parathyroid hormone related protein on chondrocyte hypertrophy: the implication for articular cartilage repair
... that deletion of Zfp521 from chondrocytes rescued Jansen metaphyseal chondrodysplasia, a disorder caused by a constitutively activating mutation of PTH1R [47]. Furthermore, PTHrP inhibits runx2 expression in chon- dro ...
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AP 1 family members act with Sox9 to promote chondrocyte hypertrophy
... of chondrocyte differentiation marker genes in the culture shown in ...(D) Chondrocyte hypertrophy in femurs cultured with ...hypertrophic chondrocyte domain, brackets indicate distance from ...
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Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
... both chondrocyte hypertrophy and bone formation in the developing skeletal ...inhibit chondrocyte hypertrophy and to suppress further Ihh expression by keeping chondrocytes in a proliferating ...
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PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy
... stimulate chondrocyte hypertrophy as it stimulates Col10a1 mRNA expression in the in vitro study ...influences chondrocyte hypertrophy; the Sik3-KO mouse exhibits delay in chondrocyte ...
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Phosphorylation of GSK 3β by cGMP dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
... Phosphorylation targets of cGKII in chondrocyte hypertrophy. To inves- tigate the mechanism underlying cGKII activity in hypertrophic differentiation of chondrocytes, we performed a screen of its phos- ...
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Wnt/β catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation
... bone. Chondrocyte hypertrophy is required for ossification because hypertrophic chondrocytes secrete factors such as Indian hedgehog (Ihh) and vascular endothelial growth factors (Vegfs), which are required ...
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Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca Akt pathways
... the hypertrophy of chondrocytes, thus maintaining proliferating chondrocyte characteristics (Akiyama et ...subsequent chondrocyte differentiation and ...to hypertrophy, is essential for ...
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Chondrocyte-specific Knockout of Cbfβ Reveals the Indispensable Function of Cbfβ in Chondrocyte Maturation, Growth Plate Development and Trabecular Bone Formation in Mice
... for chondrocyte hyper- trophy [28, ...delayed chondrocyte hypertrophy keeps chondrocyte proliferation slow but constitutive, which contributes to the elongated growth ...the chondrocyte ...
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Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders
... EO is important for development, growth, and repair of long bones. EO is initiated by the formation of cartilage templates of future bones, built by mesenchymal pro- genitor cells, which condensate and diff erentiate into ...
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Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription
... inhibits chondrocyte hypertrophy and maintains the pool of proliferative chondrocytes (Chung et ...inhibit hypertrophy forms a negative-feedback regulatory loop on the production of Ihh, which ...
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BMP4 promotes chondrocyte proliferation and hypertrophy in the endochondral cranial base
... on chondrocyte proliferation and matrix accumulation, BMP4 treatment of cranial bases at 100 ng/ml increased the proportion of hypertrophic ...ectopic chondrocyte hypertrophy in a zone surrounding ...
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Cartilage to bone transitions in health and disease
... of chondrocyte hypertrophy, is proving a critical target in osteoarthritis research due to its potent role in the degradation of collagen type-II, proteoglycans, collagen types-IV and IX, osteonectin and ...
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GIT1 gene deletion delays chondrocyte differentiation and healing of tibial plateau fracture through suppressing proliferation and apoptosis of chondrocyte
... Additionally, GIT1 gene deletion could contribute to the decreasing chondrocyte proliferation and apoptosis after tibial plateau fracture. Furthermore, a major function of GIT1 is to regulate cytoskeletal dynamics ...
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PubMedCentral-PMC5453669.pdf
... We next aim to further define how MuRF1 inhibits T3-induced cardiomyocyte hypertrophy mechanistically. We focused our attention on MuRF1’s regulation of thyroid receptor (TR) TRα1 activity, as it is the only ...
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Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy
... To further probe the involvement of IL6 in irisin signaling, we knocked down IL6 in differentiating myoblasts and queried if irisin is effective in enhancing myogenesis in the absence of IL6. Treatment with IL6-specific ...
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Exercise for the heart: signaling pathways
... cardiac hypertrophy and renewal, and exercise-induced mobilization of EPCs to proliferate, migrate and differentiate into mature endothelial cells capable of regeneration and angiogenesis as primary ...
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Reversal of pathological cardiac hypertrophy via the MEF2-coregulator interface
... and hypertrophy and contractile dysfunction were confirmed and quantified 4 weeks later by echocardiographic EF (Figure 4A), LV diastolic septal thickness (LVSd), and LVIDs (Figure 4B and Supplemental Figure ...of ...
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UNUSUAL AND RARE PRESENTATION OF HYPOTHYROIDISM (HOFFMAN SYNDROME)
... The common symptoms of myopathy due to hypothyroidism are proximal muscle weakness, muscle cramps, myxoedema on percussion, delay in deep tendon reflexes and rarely development of muscle hypertrophy. [1] Severity ...
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