Chromatin accessibility
Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development
... of chromatin accessibility, and that bind- ing of AP1 to DNA precedes local increase in chromatin ...ing accessibility of cis-regulatory ...modulate chromatin accessibility in a ...
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Reversing chromatin accessibility differences that distinguish homologous mitotic metaphase chromosomes
... in chromatin accessibility have been associ- ated with post-translational modifications to histones ...on chromatin structure [6, 17, 20], which could mask their impact on ...DNA accessibility ...
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Localized, non-random differences in chromatin accessibility between homologous metaphase chromosomes
... are precisely known. They map to a single location and can be developed from any unique region in the genome (e.g. exons, introns, intergenic, regulatory). As part of the development and validation of these single copy ...
18
KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARα
... whether chromatin open regions from the ATAC-seq analysis correlated with the KDM3B target gene expression, we integrated our ATAC- seq data with and RNA-seq ...open chromatin regions (Fig. 3f). These ...
15
Analysis of chromatin accessibility in decidualizing human endometrial stromal cells
... opening chromatin regions in decidualizing cells (34, ...increased chromatin accessibility upon decidualiza- tion, whereas sites with only FOSL2 motifs were more likely to ...opening ...
11
Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas
... Transposase-Accessible Chromatin with high-throughput sequencing ...generated chromatin accessibility maps from 336 individual nuclei, and identified variable promoter accessibility of ...
12
Integrative prediction of gene expression with chromatin accessibility and conformation data
... from chromatin conformation capture experiments or computational ...from chromatin conformation capture data can be meaningfully utilized in gene expression ...[23], chromatin accessibility ...
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Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington’s Disease Monkey pluripotent stem cells
... of chromatin accessibility, TF binding and transcription during HD astrocyte ...altered chromatin accessibility across HD astro- cyte differentiation, further investigations of ...
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Roles of cofactors and chromatin accessibility in hox protein target specificity
... for chromatin accessibility in determining where in the genome Hox proteins bind, supporting the view that chromatin accessibility gener- ally plays a key role in transcription factor target ...
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Modulating chromatin accessibility by transactivation and targeting proximal dsgRNAs enhances Cas9 editing efficiency in vivo
... with chromatin accessibility. Open chromatin is DNase I hypersensitive (DH) [18], and comprehensive DNase I hypersensitivity data for the rice genome [19] are avail- ...by chromatin openness. ...
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Chromatin accessibility plays a key role in selective targeting of Hox proteins
... of chromatin opening, and a shift in the prior chromatin accessibility profile of bound sites to- wards less accessible ...open chromatin and promote Hox ...with chromatin and raising ...
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Profiling of chromatin accessibility and identification of general cis -regulatory mechanisms that control two ocular lens differentiation pathways
... of chromatin accessibility for a single enhancer may not be sufficient to elicit any significant mRNA level ...accessible chromatin regions in ...closed chromatin in forebrain strongly ...
23
Genetic factors underlying discordance in chromatin accessibility between monozygotic twins
... open chromatin sequences, we interrogated the available array data to determine whether the genotype of each individual is a reference homozygote or variant homo-/hetero-zygote for each locus of the identified ...
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Finding potential cis regulatory loci using allele specific chromatin accessibility as weights in a kernel based variance component test
... We defined our chromatin accessibility measure to be equal to the DNase-seq read depth of each allele at a heterozygous locus. Based on our previous experience [6] the DNase-seq reads from all five GM12878 ...
6
Chromatin accessibility dynamics in the Arabidopsis root epidermis and endodermis during cold acclimation
... accessible chromatin state where TF binding is only required will save significant ...altering chromatin accessibility is a slow time consuming process and is the rate limiting step in ...
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Recapitulation-like developmental transitions of chromatin accessibility in vertebrates
... By analyzing these relative ATAC-seq signals in the mouse, chicken, and medaka, we found that maximum signals of ACRs with younger evolutionary ages tended to emerge at later developmental stages (from E9.5 in mouse, ...
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Cold stress induces enhanced chromatin accessibility and bivalent histone modifications H3K4me3 and H3K27me3 of active genes in potato
... in chromatin dynamics associated with cold-stored tubers with a long-term goal to understand potato gene expres- sion and regulation during cold ...using chromatin isolated from tubers stored at room and ...
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Chromatin accessibility: a window into the genome
... standard chromatin accessibility ...cases chromatin accessibility can be accurately determined with single-end, shorter-length reads without the unnecessary additional ...
16
Hartlepp, Klaus F. (2006): Characterisation of CHRAC14 and CHRAC16, the two Histone Fold Subunits of the Chromatin Accessibility Complex. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... active Chromatin Accessibility Complex, but so far, co-expression and co-purification of all four subunits together do not give satisfying results (see ...ATP-dependent chromatin remodelling ...
144
Transcription-coupled recruitment of human CHD1 and CHD2 influences chromatin accessibility and histone H3 and H3.3 occupancy at active chromatin regions
... DNase accessibility, H3 occupancy and ...affects accessibility strongly with weaker affects on H3 occupancy, while CHD2 affects H3 occupancy and ...regulates chromatin accessibility. ...
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