chromosome inactivation
No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans
... Skewing of X chromosome inactivation (XCI) can occur in normal females and increases in tissues with age. The mechanisms underlying skewing in normal females, however, remain controversial. To better ...
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Skewed X-chromosome inactivation in patients with esophageal carcinoma
... Abstract: Skewed X-chromosome inactivation (SXCI) was found in some apparently healthy females mainly from Western countries. It has been linked to development of ovarian, breast and pulmonary carcinomas. ...
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X chromosome inactivation revealed by the X linked lacZ transgene activity in periimplantation mouse embryos
... X chromosome inactivation occurs first in the trophec- toderm of ...X- inactivation has been considered to be coupled with cell differen- tiation (Monk and Harper, ...
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Detailed analysis of X chromosome inactivation in a 49,XXXXX pentasomy
... X chromosome inactivation is usually random [32], consequently to which every X chro- mosome may be inactivated in a given cell during early development; once inactivated, this state is stably main- tained ...
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Skewed X-chromosome inactivation in scleroderma.
... X-chromosome inactivation (6,7) have been proposed as the underlying pathophysiological mechanisms leading to the female prevalence of autoimmune ...X- inactivation mosaicism (12) have been shown to ...
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X chromosome inactivation in the cycle of life
... X chromosome inactivation (XCI), which leads to mono-allelic expression of most X-linked ...X chromosome (Xp) is initiated in the female cleavage-stage embryo and is maintained in extra-embryonic ...
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X-chromosome inactivation, DNA methylation and imprinting
... whole chromosome (Monk, 1986; Riggs, ...X- chromosome inactivation in female cells, many correlations between méthylation and X-linked gene function have been recorded (reviewed by Monk, ...
434
A skewed view of X chromosome inactivation
... X chromosome inactivation involves a random choice to silence either X chromosome early in mammalian female ...X chromosome inactiva- tion is observed in a percentage of ...X chromosome ...
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Low RNA Binding Strength of Human X Chromosome May Explain X Chromosome Inactivation
... X chromosome in early embryonic development and all the daughter cells produced from these cells retain the same feature of X chromosome inactivation, which is called X chromosome ...
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X Chromosome Inactivation in Opioid Addicted Women
... X chromosome inactivation (XCI), leads to gene dosage equivalence between females and males who have only one X chromosome (Pollex & Heard, ...X chromosome in each cell remains inacti- ...
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A new model for random X chromosome inactivation
... X chromosome inactivation (XCI) is a process by which mammals reduce the number of active X chromosomes to one per diploid set of autosomes, thereby allowing for dosage equality between the ...the ...
10
Meiotic sex chromosome inactivation
... X chromosome inactivation (XCI) (see Table ...X chromosome from which it is transcribed (termed acting in-cis) (Penny et ...X chromosome that induce gene silencing by catalysing methylation, ...
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The Evolution of Genomic Imprinting and X Chromosome Inactivation in Mammals
... X chromosome dosage compensation in female eutherian ...X chromosome inactivation (XCI) and autosomal genomic imprinting that have long been noted ...Once inactivation was fixed on the X chro- ...
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An investigation into the role of sex chromosome synapsis in meiotic sex chromosome inactivation and fertility
... on chromosome XU with rDNA on multi-copy circular plasmids also disrupts checkpoint function, even though the plasmids form a ‘pseudonucleolus’ in which Pch2 is ...
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The role of X chromosome inactivation in female predisposition to autoimmunity
... X inactivation in the thymic dendritic cell population, a particular thymocyte might not come into contact with dendritic cells that express one of the two X ...X inactivation should only be directed at ...
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Carrier detection in X linked severe combined immunodeficiency based on patterns of X chromosome inactivation
... X chromosome bearing the XSCID mutation was inactivated early in ...X inactivation pattern in XSCID carriers and their female ...X chromosome bearing the XSCID mutation was consistently ...X ...
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Mammalian X chromosome inactivation evolved as a dosage compensation mechanism for dosage sensitive genes on the X chromosome
... XY chromosome evolution, be- cause males only have one copy of the X ...X chromosome global expression is about half the expression of autosomes in both male and female ...
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Nonrandom X Chromosome Inactivation Is Influenced by Multiple Regions on the Murine X Chromosome
... background differences and tissues chosen for the analysis did not affect the outcome. However, there was a greater variance in gene expression measurements when tail RNA was used for the analysis instead of toe and ear ...
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Chromosome silencing mechanisms in X chromosome inactivation: unknown unknowns
... Xist-mediated chromosome silencing: first, that Xist produces a functional non-coding (nc) RNA that recruits factors required for heterochromatin formation; and second that the active Xist locus somehow ...
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REGULATION OF X-CHROMOSOME INACTIVATION IN MAMMALS
... Experimental evidence demonstrates a strict parallel between heterochromatization and genetic inactivity; in general, as shown by conventional genetic markers (BROWN and WEI[r] ...
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