Chronic Constriction Injury
EFFECT OF ZONISAMIDE ON CHRONIC CONSTRICTION INJURY INDUCED NEUROPATHIC PAIN IN MALE SD RATS
... There is considerably research evidence supporting a palliative role for voltage-gated sodium and T-type calcium channels in neuropathic pain conditions. Hence, the present study was undertaken to assess the ability of ...
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Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti oxidative, anti inflammatory, neuroprotective and calcium inhibitory effects
... Peripheral neuropathy was induced in rats by chronic constriction injury as described method of Bennett and Xie [10] with slight modifications of Sommer and Schafers [42]. In brief, the rats were ...
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Reduced GABAergic neuronal activity in zona incerta causes neuropathic pain in a rat sciatic nerve chronic constriction injury model
... Purpose: The zona incerta (ZI) is below the ventral tier of the thalamus and has a strong influ- ence selectively in higher-order thalamic relays. Although neuropathic pain has been suggested to result from reduced ...
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AMELIORATIVE EFFECTS OF MURRAYA KOENIGII IN CHRONIC CONSTRICTION INJURY OF SCIATIC NERVE INDUCED NEUROPATHIC PAIN IN RATS
... by chronic constriction injury of sciatic nerve in ...a chronic condition which is characterized by the sensory symptoms like hyperalgesia and ...nerve injury produces robust thermal ...
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Intraperitoneally Administered Lidocaine Attenuates Thermal Allodynia in a Murine “Two Hit” Chronic Constriction Injury Model
... Figure 3. Cytokine levels in plasma after 2 hours MV. Levels of interleukin (IL)-1β, IL-6, IL-10, keratinocyte derived chemokine (KC) and tumor necrosis factor (TNF)-α keratino- cyte derived chemokine (KC), in ventilated ...
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Bilateral changes of TNF-α and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve
... Interleukin 10 (IL-10) is one of the most important reg- ulators of the immune system. Although IL-10 is known to have many different roles in immune reaction, it is a powerful member of the anti-inflammatory cytokine ...
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Ameliorative potential of Alstonia scholaris (Linn ) R Br against chronic constriction injury induced neuropathic pain in rats
... Methods: Peripheral neuropathy was induced by chronic constriction injury of sciatic nerve. The behavioral parameters like mechanical and thermal hyperalgesia and cold allodynia were assessed on the ...
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Analyses of gene expression profiles in the rat dorsal horn of the spinal cord using RNA sequencing in chronic constriction injury rats
... CCI: Chronic constriction injury; DAVID: Database for Annotation, Visualization and Integrated Discovery; DEGs: Differentially expressed genes; ERKs: Extracellular receptor- activated kinases; FPKM: ...
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Contributions of p38 and ERK to the antinociceptive effects of TGF-β1 in chronic constriction injury-induced neuropathic rats
... neuroprotective roles in various experimental models. We previously reported that intrathecal (i.t.) injections of TGF- β 1 significantly inhibit neuropathy-induced thermal hyperalgesia, spinal microglia and astrocyte ...
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Original Article Overexpression of miR-30a attenuates neuropathic pain by targeting SOCS1 in rats with chronic constriction injury
... Abstract: Objectives: To explore the impact of miR-30a on neuropathic pain and associated mechanism. Methods: Sprague-Dawley (SD) rats were randomly assigned to bilateral chronic constriction injury ...
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WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms
... brain injury and multiple ...by chronic constriction injury (CCI) of the mouse sciatic nerve and examined by Hargreaves and Von Frey ...
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TLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice
... complex, chronic pain state characterized by hyperalgesia, allodynia, and spontaneous ...a chronic constriction injury (CCI)-induced neuropathic pain model in wild-type (WT) and TLR4-knockout ...
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Application of the chronic constriction injury of the partial sciatic nerve model to assess acupuncture analgesia
... Different sciatic nerve compression or ligation models could induce different influences on C-fiber reflexes. The CCI model can cause a diffused lesion on efferent fibers and thus damage muscle innervation of the sciatic ...
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A bacosides containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats
... the chronic constriction injury model of neuro- pathic pain under standardized experimental ...nerve injury combined with testing of pain hypersensitivity are useful in representing human ...
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Contralateral monoarthritis exacerbated chronic constriction injury-induced pain hypersensitivity through upregulating inducible nitric oxide synthase
... Introduction: High comorbidity of osteoarthritis (OA) and neuropathic pain has been reported in aged patients. Evidence shows that central sensitization of pain processing occurs in late-phase OA and may facilitate the ...
Original Article Xanthotoxol attenuates neuropathic pain in a rat model of chronic constriction injury
... monocytic THP-1 cells [9]. Most notably, XN exhibited potent neuroprotective activity, treat- ment with XN dose-dependently attenuated focal cerebral ischemia and improved neurobe- havioral deficits in cerebral ischemic ...
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Original Article Involvement of spinal SIRT1 in development of chronic constriction injury induced neuropathic pain in rats
... and hyperalgesia in neuropathic pain. The neuropathic pain model was established by ligature of the right sciatic nerve to induce chronic constriction injury (CCI) in rats. Histone acetyltransferase ...
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Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn
... Methods: To test whether neuropathic pain influences circRNA expression, we developed a sciatic chronic constriction injury (CCI) model in rats. The CCI ipsilateral spinal dorsal horns of lumbar ...
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The Antinociceptive Effects of Rosuvastatin in Chronic Constriction Injury Model of Male Rats
... In our study, we found that neuropathic pain leads to increase in the level of inflammatory markers, including TNF-α and IL-6. It has already been demonstrated that TNF-α plays an important role in central and periph- ...
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Pregnancy suppresses neuropathic pain induced by chronic constriction injury in rats through the inhibition of TNF-α
... Materials and methods: Female Sprague Dawley rats (200–250 g) were randomly assigned to one of four groups (pregnant + chronic constriction injury [CCI]; pregnant + sham injury; not pregnant + ...
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