Chronic myeloid leukemia
Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia
... including chronic myeloid leukemia (CML), poly- cythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) which have different molecular abnormalities including mutations ...
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<p>Myeloid Blast Crisis of Chronic Myeloid Leukemia Followed by Lineage Switch to B-Lymphoblastic Leukemia: A Case Report</p>
... Abstract: Lineage switch is very rare in blastic crisis of chronic myeloid leukemia (CML- BC). Here, we report a case of CML-BC in which the blast lineage switched from myeloid to B-lymphoid. ...
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The impact of tyrosine kinase inhibitors on thyroid function tests among sudanesepatients with chronic myeloid leukemia
... for chronic myeloid leukemia, patients are regular attendants for follow up and prescription drug, ph +ve CML under glivic imitinab, for resistant glivic imitinab a restosine is set as a substitution ...
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Masked inv dup(22)(q11.23), tetrasomy 8 and trisomy 19 in a blast crisis-chronic myeloid leukemia after interrupted Imatinib-treatment
... Chronic myeloid leukemia (CML) is a myeloprolifera- tive disorder associated with the presence of Philadel- phia (Ph) chromosome or also is called a derivative chromosome 22 ...early chronic ...
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<p>A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia</p>
... Abstract: Chronic myeloid leukemia (CML) and Non-Hodgkin Lymphoma (NHL) are two different origins of hematological malignancies, which rarely occur at the same ...of chronic phase (CP) CML ...
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Bosutinib: a SRC–ABL tyrosine kinase inhibitor for treatment of chronic myeloid leukemia
... of chronic myeloid ...in chronic myeloid leukemia, especially in the chronic phase, with resistance or intolerance to prior tyrosine kinase ...
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Imatinib Mesylate in the Treatment of Chronic Myeloid Leukemia: A Local Experience
... Imatinib Mesylate in the Treatment of Chronic Myeloid Leukemia A Local Experience ORIGINAL ARTICLE Imatinib Mesylate in the Treatment of Chronic Myeloid Leukemia A Local Experience PC Bee, MMed*, G G[.] ...
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Individualizing kinase targeted cancer therapy: the paradigm of chronic myeloid leukemia
... transformed chronic-phase chronic myeloid leukemia (CML-CP) from a lethal can- cer into a chronic disorder that is compatible with a largely normal span and quality of ...
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Dasatinib in chronic myeloid leukemia: a review
... for chronic myeloid leukemia (CML), which provides an identifi able target for developing therapeutic ...with chronic phase CML, the rate of resistance to imatinib at 4 years was up to 20%, ...
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Advances in the treatment of chronic myeloid leukemia
... diagnosed chronic myeloid LeukemiA) tested bosu- tinib, a second generation TKI not currently approved, versus imatinib in newly diagnosed ...cing leukemia burden faster and more ...
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Karyotyping in Chronic Myeloid Leukemia
... Conventional cytogenetic studies need actively replicating cells that are usually obtained in marrow of bones. Highly proliferating cells are also seen in lymph nodes, chorionic villi and solid tissues. When peripheral ...
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A novel BCR-ABL1 fusion gene with genetic heterogeneity indicates a good prognosis in a chronic myeloid leukemia case
... Background: Chronic myelogenous leukemia (CML) is a pluripotent hematopoietic stem cell disorder caused by the fusion of the BCR and ABL1 genes. Quantitative RT-PCR (qRT-PCR) is a routinely performed ...
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Quality control, modeling, and visualization of CRISPR screens with MAGeCK VISPR
... two leukemia cell lines in the leukemia dataset (a), and two biological replicates of mouse ESC cells in the ESC dataset ...different leukemia subtypes (HL60: acute myeloid leukemia; ...
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The changing face of clinical trials in the personalized medicine and immuno-oncology era: report from the international congress on clinical trials in Oncology & Hemato-Oncology (ICTO 2017)
... lymphoblastic leukemia; ATO: Arsenic trioxide; ATRA: All-trans retinoic acid; CDx: Companion diagnostics; CLL: Chronic lymphocytic leukemia; CML: Chronic myeloid leukemia; CR: ...
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IGF-IR determines the fates of BCR/ABL leukemia
... Methods and results: Here we investigated the role of IGF-IR in chronic myeloid leukemia (CML) using the retroviral BCR/ABL transplantation mouse model. Existing antibodies against IGF-IR are not ...
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Familial risks of acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms.
... The myeloid malignancies comprising the myeloproliferative neoplasms (MPNs), polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF), and chronic myeloid leukemia (CML), ...
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Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
... Acute myeloid leukemia; BM: Bone marrow; CML: Chronic myeloid leukemia; CR: Complete remission; HSCT: Hematopoietic stem cell transplantation; PB: Peripheral blood; PBMCs: Peripheral ...
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Understanding cell signaling in cancer stem cells for targeted therapy – can phosphoproteomics help to reveal the secrets?
... CLL: Chronic lymphatic leukemia; CML: Chronic myeloid leukemia; CRPC: Castration-resistant prostate cancer; CSC: Cancer stem cells; CXCR4: G protein-coupled receptor chemokine receptor ...
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Case Report Fourth malignancy after treatment of Hodgkin’s lymphoma: a case report
... Abstract: Objective: To evaluate the incidence and treatment of the fourth malignancy in a Hodgkin’s lymphoma (HL) patient. Methods: We reported a HL patient after treatment that developed the second, third, and fourth ...
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Original Article Chronic neutrophilic leukemia with JAK2 V617F mutation: a case report
... A mutation of V617F (a change of valine to phe- nylalanine at the 617 position) in JAK2 was found to be implicated in polycythemia vera (PV), essential thrombocythemia (ET), and pri- mary myelofibrosis (PMF) by Baxter in ...
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