Chronic Unpredictable Mild Stress.
Original Article Potential antidepressant role of low-dose naltrexone in a rat model of chronic unpredictable mild stress
... Abstract: Objectives: We aimed to investigate antidepressant effect of low-dose naltrexone (LDN) and to explore its potential mechanism of action using a rat model induced by chronic unpredictable ...
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Original Article L-theanine improves depressive behavioral deficits by suppressing microglial activation in a rat model of chronic unpredictable mild stress
... Abstract: L-Theanine (N-ethyl-L-glutamine) is an amino acid originally and uniquely found in green tea. Historically L-theanine has been recognized as a relaxing agent. Some studies have shown that L-theanine has ...
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ANTIDEPRESSANT LIKE ACTIVITY OF FLOWERS OF TECOMELLA UNDULATA IN MICE SUBJECTED TO CHRONIC UNPREDICTABLE MILD STRESS
... When chronic stress is subjected to animals, the same change in hyperactivity of the HPA axis has been observed ...[7]. Stress has an important role in the development of human depression ...to ...
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Resveratrol ameliorates chronic unpredictable mild stress-induced depression-like behavior: involvement of the HPA axis, inflammatory markers, BDNF, and Wnt/β-catenin pathway in rats
... via chronic unpredictable mild stress (CUMS), after which the model rats in the RES and fluoxetine groups received a daily injection of RES or fluoxetine, ...factor, chronic ...
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Antidepressant-like effects of Ficus deltoidea aqueous extract on chronic unpredictable mild stress-treated rats
... Depression is a common and debilitating mental disorder. The present study was undertaken to investigate the antidepressant-like effects of the aqueous extract of Ficus deltoidea (FD) leaves. Sprague-Dawley rats treated ...
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Evaluation of behavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress
... Methods: 60% methanolic extract of CS was quantified for phenolic content by Folin-Ciocalteau's method. Chronic unpredictable mild stress (CMS) was employed to induce stress in rats. CS ...
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Fish oil supplementation alleviates depressant like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress
... Recent findings have shown that adipocyte-derived hormone, leptin and adiponectin, and the gut hormone, grehlin play critical roles in energetic homeostasis, insulin sensitivity and lipid metabolism [10–12]. ...
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The effect of Piper laetispicum extract (EAE P) during chronic unpredictable mild stress based on interrelationship of inflammatory cytokines, apoptosis cytokines and neurotrophin in the hippocampus
... the chronic unpredictable mild stress (CUMS) model in Sprague -Dawley rats was used to further elucidate the antidepressant-like effects and mechanism of ...of mild stressors, which ...
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Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats
... The chronic unpredictable mild stress (CMS) ani- mal model is valid, reliable and sensitive for studying depressive disorders in rats ...between chronic stress and serum lipid ...
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Β- Glucan, a Polysaccharide Found in Avena sativa (Oat), Attenuated Chronic Unpredictable Mild Stress Induced Cognitive Impairment in Rodents via Normalizing Corticosterone Levels
... in stress induced cognitive ...of stress on various parameters (Stay time in target quadrant, latency to enter the target quadrant and number of entries in the target quadrant) observed in MWM as shown in ...
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EVALUATION OF SIRTUIN 3 BIOMARKER BEFORE AND AFTER EXERCISE REGIMEN IN CHRONIC UNPREDICTABLE MILD STRESS INDUCED DEPRESSED RATS
... by chronic stress through the alteration in the expression of sirt3 in ...brain. Stress is known to exacerbate depression in susceptible individuals ...performing stress procedures, as the ...
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ASSESSMENT OF ANXIOLYTIC ACTIVITY OF AQUEOUS EXTRACT OF MANGIFERA INDICA L. LEAVES IN RODENTS EXPOSED TO CHRONIC UNPREDICTABLE MILD STRESS
... Anxiety is a normal response to stress, a feeling of apprehension or fear, combined with the symptoms of increased sympathetic activity. A clinical problem may arise if anxiety becomes persistent that interferes ...
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The depressive-like behaviors of chronic unpredictable mild stress-treated mice ameliorated by Tibetan medicine Zuotai: involvement in the hypothalamic–pituitary–adrenal (HPA) axis pathway
... these stress methods include the following: 1) food deprivation for 24 h; 2) drinking water deprivation for 24 h with no drink bottle; 3) cage tilted at a 45 ° angle for 24 h; 4) placed together as a group for 2 ...
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Antidepressant like effects of acupuncture involved the ERK signaling pathway in rats
... Chronic unpredictable mild stress (CUMS) can be used as a valid and reliable method by which to build an ani- mal model of depression ...
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Postpartum depression: psychoneuroimmunological underpinnings and treatment
... The weeks that separate parturition and the emergence of PPD are often stressful, typically incorporating a brief depressive period of “baby blues.” In the animal literature, a series of novel stressors is used to induce ...
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Expression alteration of microRNAs in Nucleus Accumbens is associated with chronic stress and antidepressant treatment in rats
... like behaviors in mice, we used an established protocol, chronic unpredictable mild stress (CUMS) (Fig. 1a) [20]. We analyzed small RNA sequence data from both of these groups (Fig. 1b). The ...
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Fto Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice via Alterations in Gut Microbiota
... CUMS: chronic unpredictable mild stress; SNPs: single-nucleotide polymorphisms; BAT: brown adipose tissue; WAT: white adipose tissue; MDD: major depressive disorder; HPA: hypothal- ...
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Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress
... The sucrose preference test is used to validate animal models of depression, especially chronic mild stress (CMS). When given a choice between sweetened solu- tions and tap water, rodents prefer to ...
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Involvement of the glutamate/glutamine cycle and glutamate transporter GLT 1 in antidepressant like effects of Xiao Yao san on chronically stressed mice
... that chronic mild, predictable stress not only leads to increased glutamate release but also results in EAAT2 elevation ...predictable stress has a benefi- cial effect on the depressive and ...
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CHRONIC UNPREDICTABLE STRESS INDUCED BEHAVIORAL AND ELECTROPHYSIOLOGICAL ALTERATIONS AND ITS AMELIORATIVE EFFECT BY MYRICETIN MICROEMULSION
... that unpredictable mild stress showed significantly decreased time domain analysis such as R-R interval and RMSSD in HRV index, this is consistent with our present findings, CUS- exposed animals ...
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