Chronic unpredictable mild stress (CUMS)
Antidepressant-like effects of Ficus deltoidea aqueous extract on chronic unpredictable mild stress-treated rats
... with chronic unpredictable mild stress (CUMS) for 4 weeks were used as depression ...in CUMS-treated ...on CUMS-treated ...
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Original Article L-theanine improves depressive behavioral deficits by suppressing microglial activation in a rat model of chronic unpredictable mild stress
... reported. Chronic unpredictable mild stress (CUMS) with solitary condition exposed rats exhibits several neu- robehavioral alterations that resemble symp- toms of chronic ...
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Fish oil supplementation alleviates depressant like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress
... Recent findings have shown that adipocyte-derived hormone, leptin and adiponectin, and the gut hormone, grehlin play critical roles in energetic homeostasis, insulin sensitivity and lipid metabolism [10–12]. ...
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The effect of Piper laetispicum extract (EAE P) during chronic unpredictable mild stress based on interrelationship of inflammatory cytokines, apoptosis cytokines and neurotrophin in the hippocampus
... the chronic unpredictable mild stress (CUMS) model in Sprague -Dawley rats was used to further elucidate the antidepressant-like effects and mechanism of ...EAE-P. CUMS, the most ...
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Original Article Potential antidepressant role of low-dose naltrexone in a rat model of chronic unpredictable mild stress
... by chronic unpredictable mild stress ...The CUMS-induced rat model was established, and the antidepressant effect of LDN ...of CUMS, including decreased sucrose preference, ...
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Resveratrol ameliorates chronic unpredictable mild stress-induced depression-like behavior: involvement of the HPA axis, inflammatory markers, BDNF, and Wnt/β-catenin pathway in rats
... via chronic unpredictable mild stress (CUMS), after which the model rats in the RES and fluoxetine groups received a daily injection of RES or fluoxetine, ...of CUMS rats, as ...
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ANTIDEPRESSANT LIKE ACTIVITY OF FLOWERS OF TECOMELLA UNDULATA IN MICE SUBJECTED TO CHRONIC UNPREDICTABLE MILD STRESS
... When chronic stress is subjected to animals, the same change in hyperactivity of the HPA axis has been observed ...[7]. Stress has an important role in the development of human depression ...to ...
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Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats
... The chronic unpredictable mild stress (CMS) ani- mal model is valid, reliable and sensitive for studying depressive disorders in rats ...between chronic stress and serum lipid ...
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Evaluation of behavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress
... Methods: 60% methanolic extract of CS was quantified for phenolic content by Folin-Ciocalteau's method. Chronic unpredictable mild stress (CMS) was employed to induce stress in rats. CS ...
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EVALUATION OF SIRTUIN 3 BIOMARKER BEFORE AND AFTER EXERCISE REGIMEN IN CHRONIC UNPREDICTABLE MILD STRESS INDUCED DEPRESSED RATS
... The CUMS protocol was performed according to previous study ...following CUMS procedure: Cage tilting (tilt at 45°C angle) for 24 h, crowded housing (5 rats per cage), noises for 1 h (alternative periods of ...
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ASSESSMENT OF ANXIOLYTIC ACTIVITY OF AQUEOUS EXTRACT OF MANGIFERA INDICA L. LEAVES IN RODENTS EXPOSED TO CHRONIC UNPREDICTABLE MILD STRESS
... The purpose of this study was to characterize the anxiolytic activity of an Aqueous extract prepared from the leaves of Mangifera indica L (AEMI) using an elevated plus maze (EPM) model in rat and staircase model in ...
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The depressive-like behaviors of chronic unpredictable mild stress-treated mice ameliorated by Tibetan medicine Zuotai: involvement in the hypothalamic–pituitary–adrenal (HPA) axis pathway
... in CUMS-treated mice, characterized by increased SPR in the SPT, increased total movement distance and percentage of time to cross the center in the OFT, and improved body weight as well as motor activities in ...
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Fto Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice via Alterations in Gut Microbiota
... gene; CUMS: chronic unpredictable mild stress; SNPs: single-nucleotide polymorphisms; BAT: brown adipose tissue; WAT: white adipose tissue; MDD: major depressive disorder; HPA: ...
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Antidepressant like effects of acupuncture involved the ERK signaling pathway in rats
... Chronic unpredictable mild stress (CUMS) can be used as a valid and reliable method by which to build an ani- mal model of depression ...that CUMS induced an obvious decrease in ...
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Postpartum depression: psychoneuroimmunological underpinnings and treatment
... of chronic unpredictable mild stress ...of CUMS is an increase in peripherally derived kyn, leading to increased levels of QUIN in the amygdala and striatum, as well as a trend increase ...
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Expression alteration of microRNAs in Nucleus Accumbens is associated with chronic stress and antidepressant treatment in rats
... like behaviors in mice, we used an established protocol, chronic unpredictable mild stress (CUMS) (Fig. 1a) [20]. We analyzed small RNA sequence data from both of these groups (Fig. ...
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Ficus sycomorus extract reversed behavioral impairment and brain oxidative stress induced by unpredictable chronic mild stress in rats
... no stress (treated with saline), CUMS group (exposed to chronic stress and treated with saline only), CUMS + imipramine 20 mg/kg, CUMS + ...mg/kg, CUMS + ...
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Involvement of the glutamate/glutamine cycle and glutamate transporter GLT 1 in antidepressant like effects of Xiao Yao san on chronically stressed mice
... in CUMS mice were in agreement with those data except ...that chronic mild, predictable stress not only leads to increased glutamate release but also results in EAAT2 elevation ...predictable ...
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Hippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice
... in CUMS-exposed ...demonstrated chronic mild stress (CMS) significantly downregulated hippocampal RAGE protein ...and stress protocol may be two possible ...four-week ...
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Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress
... The sucrose preference test is used to validate animal models of depression, especially chronic mild stress (CMS). When given a choice between sweetened solu- tions and tap water, rodents prefer to ...
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