CII, collagen type II
Collagen type II (CII) specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII reactive T cells
... To understand the role of B and T cells in antibody-medi- ated inflammation, mice deficient in either B cells or T cells or both were injected with a combination of two different monoclonal antibodies against CII. ...
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Transplantation of gingiva derived mesenchymal stem cells ameliorates collagen induced arthritis
... Fig. 2 Gingival-derived mesenchymal stem cells (GMSCs) attenuate the inflammatory responses in collagen-induced arthritis (CIA) mice via a Fas/FasL pathway. a Schema showing GMSC infusion in CIA mice. b Arthritis ...
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Collagen types I and II distribution: a relevant indicator for the functional properties of articular cartilage in immobilised and remobilised rabbit knee joints
... of type I and type II ...monoclonal collagen type I antibody (Clone ...monoclonal collagen type II antibody (Clone No. II-II6B3-s and cII cI-c, ...
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Interleukin 7 aggravated joint inflammation and tissue destruction in collagen induced arthritis is associated with T cell and B cell activation
... CIA: collagen-induced arthritis; CII: chicken collagen type II; DN: double negative; DP: double positive; EGF: epidermal growth factor; FGF: fibroblast growth factor; HE: ...
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Collagen induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis
... batch collagen type II (CII) was prepared, extracted from bovine hyaline ...Experiments II and III, two industry-grade commercially available types of CII were used, respectively ...
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Type II collagen antibody response is enriched in the synovial fluid of rheumatoid joints and directed to the same major epitopes as in collagen induced arthritis in primates and mice
... with CII in the various species leading to strong anti-CII antibody responses, the fine specificity of the major epitopes was still largely ...peptide CII library showed that numerous epitopes could ...
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Anti type II collagen immune complex induced granulocyte reactivity is associated with joint erosions in RA patients with anti collagen antibodies
... gen type II (CII) is a major component of joint ...of collagen type II autoanti- bodies (anti-CII) in serum and increased C-reactive protein (CRP) levels and erythrocyte ...
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Indoleamine 2,3 dioxygenase expressing dendritic cells are involved in the generation of CD4+CD25+regulatory T cells in Peyer's patches in an orally tolerized, collagen induced arthritis mouse model
... of type II collagen induces immune tolerance and inhibits arthritis development The arthritis index remained low in both the tolerance and CIA groups until 4 weeks after primary immunization with ...
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Anti type II collagen antibodies are associated with early radiographic destruction in rheumatoid arthritis
... that CII antibodies might stimulate macrophages and fibroblasts within the synovium to produce the metalloproteinases that are responsible for being the first enzymes to cleave the interstitial collagens, ...
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The CII specific autoimmune T cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis
... the type II collagen (CII)-specific T-cell ...with CII on day 0 and split into four groups for treatment: (1) FTY720 + anti-CD25 antibody (Ab), (2) vehicle + anti-CD25 antibody, (3) ...
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Soluble PD 1 aggravates progression of collagen induced arthritis through Th1 and Th17 pathways
... chick type II collagen (CII; Sigma-Aldrich) overnight at 4 °C in 10 mM acetic acid and combining it with an equal vol- ume of complete Freund’s adjuvant containing 5 mg/ml heat-killed ...
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Auricular chondritis in NOD DQ8 Aβo (Ag7–/–) transgenic mice resembles human relapsing polychondritis
... class II molecules (Aβo). Upon immunization with type II collagen (CII), 85% of ...humans. CII-immunized mice mount a T cell response and produce Ab’s to type IX ...
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Mice expressing HLA DQ6α8β transgenes develop polychondritis spontaneously
... Young mice (6–8 weeks of age) expressing the HLA-DQ6α8β molecule, either the DQ6α8β transgenic (tg) or DQ6αβ8αβ tg strains, develop polychondritis following immunization with an emulsion of type II ...
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Human embryonic stem cell derived mesenchymal stromal cells ameliorate collagen induced arthritis by inducing host derived indoleamine 2,3 dioxygenase
... 3 Type II collagen (CII)-specific T cell responses in vitro and anti-CII antibody levels in embryonic stem cell-derived mesenchymal stromal cells (hESC-MSC)-treated ...to CII by ...
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VDIPEN, a metalloproteinase generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis
... Abbreviations used in this paper: AC, articular cartilage; CII, type II collagen; CIA, type H collagen-induced arthritis; CLN, collagenase; ECM, extracellular matrix; GLN-A, gelatinase A[r] ...
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Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1 CreERT2; Ihhfl/fl mice
... types II and X collagens (Developmental Studies Hybridoma Bank, University of Iowa, Iowa City, IA, USA) and type II colla- gen breakdown product (IBEX Technologies, Mont-Royal, QC, Canada), ...
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Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase 13 from human osteoarthritic cartilage
... triple-helical collagen is an important step in the progression toward irreversible tissue damage in os- ...cleaved type II collagen to give characteristic 3/4 and 1/4 fragments; however, ...
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Adoptive transfer of suppression of arthritis in the mouse model of collagen induced arthritis Evidence for a type II collagen specific suppressor T cell
... of collagen-induced ...native type II collagen 3 d before immunization with native type II collagen emulsified in complete Freund's adjuvant resulted in animals with ...
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Degradation of Extracellular Matrix Molecules in Interleukin-1 Alpha Treated Bovine Nasal Cartilage
... to collagen type II via collagen IX and also binding of FM to collagen II, degradation of the components under IL-1α condition may involve whole collagen network and lead ...
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Exposure to Mimivirus Collagen Promotes Arthritis
... mimivirus collagen and the development of autoim- munity was corroborated by the occurrence of IgG against mimi- virus collagen among rheumatoid arthritis ...virus collagen and to a breakdown of im- ...
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