circadian clock
<p>The role of circadian clock genes in tumors</p>
... Previous research has shown that decreases in the expression of Per2 can directly inhibit the activation of the P53 protein and lead to accelerated tumor development. 52 In addition, Per2 overexpression increases the ...
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The role of the circadian clock in rheumatoid arthritis
... e circadian clock is fundamental in the regulation of metabolic processes; controlling expression of genes involved in metabolic pathways but also responding to metabolic cues ...[32]. Circadian ...
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Circadian Clock Gene Bmal1 Regulates Bilirubin Detoxification: A Potential Mechanism of Feedback Control of Hyperbilirubinemia
... of circadian bile acid metabolism can result in hepatic stress responses and liver injury [4] ...The circadian pattern of bilirubin is altered in individuals with abnormal sleep ...by circadian ...
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REVERBa couples the circadian clock to hepatic glucocorticoid action.
... conferring clock control to lipogenic gene expression (15), and recent discoveries identify both DNA binding regulation of the core clock and DNA binding–independent regulation of energy metabolism as ...
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Unproductive alternative splicing and nonsense mRNAs: A widespread phenomenon among plant circadian clock genes
... of circadian rhythms in ...and circadian networks through a thorough evaluation of AS of plant circadian clock genes using ...many circadian clock- associated genes in ...
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Plausible link between circa‘bi’dian activity rhythms and circadian clock systems in the large black chafer Holotrichia parallela
... circabidian clock, a phase shift of a half- cycle ( ∼ 24 h) of the clock had to occur to switch the appearance ...oscillator-type clock, it is hard to make a half-period phase shift at one time ...
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Circadian Clock Regulated Gene Expression in the Hypothalamus
... master circadian clock in mammals is the suprachiasmatic nucleus of the hypothalamus ...into circadian regulation of neuronal connectivity, synaptic transmission, ion homeostasis, splicing factors ...
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Deregulated expression of circadian clock genes in gastric cancer
... In this study, we observed an up-regulation of PER2 in GCs. PER2 play an important role in tumor suppression and DNA damage response in vivo [27]. Our previous studies have revealed down-regulation of PER2 in HCC [18], ...
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Molecular mechanisms of circadian clock functioning
... biological CLOCK present in all cells. However, there is also a cen tral CLOCK – the primary circadian pacemaker which is localized in the supraсhiasmatic nuc lei of the mammalian ...this ...
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The critical role of the Arabidopsis circadian clock at high temperature
... the circadian clock has in controlling several physiological traits, scientists often imagined this complex mechanism, evolved several times, could be critical for plants’ ...lacking circadian ...
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The Expression of Circadian Clock Gene Promoters in Arabidopsis Callus.
... containing clock gene promoters fused to luciferase gene by Agrobacterium transformation and callus induction from seedlings and setting the system for detecting bioluminescence to determine the expression of gene ...
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Timed high-fat diet in the evening affects the hepatic circadian clock and PPARα-mediated lipogenic gene expressions in mice
... hepatic circadian clock is ...hepatic circadian clock and clock-controlled per- oxisome proliferator-activated receptor (PPAR) a-medi- ated lipogenic gene ...hepatic clock genes, ...
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The circadian clock in mammals
... the circadian cycle and that CREB can only be phosphory- lated in response to light during the subjective night, sug- gests that gating may occur upstream of the phosphorylation step ...the circadian ...
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Ultradian oscillators of the circadian clock in Saccharomyces cerevisiae
... of circadian day length ...the circadian day length in h ...separate clock rhythms, each regulating GAPDH activity independently of the ...are clock regulated has not been ...
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Structural investigation of the Arabidopsis thaliana circadian clock
... Ampicilin Arabidopsis Response Receiver Basic Local Alignment Sequence Tool protein CHLOROPHYLL NB BINDING PROTEIN CCA 1 binding site CIRCADIAN CLOCK ASSOCIATED 1 COLD AND CIRCADIAN REGU[r] ...
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Circadian Clock Proteins and Immunity
... master clock resides in the suprachiasmatic nucleus (SCN) of the brain and is oriented to the external environment via the retinohypothalamic tract receiving light information from the ...The clock is cell ...
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Testing the Robustness of the Circadian Clock
... the circadian clock (Hardin 2011). The clock is a genetically based system that allows for predictable physiological responses to environmental changes, enabling animals to better survive in their ...
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Robustness from flexibility in the fungal circadian clock
... observed circadian rhythms in Neurospora - including the conidiation rhythm - is formed by the rhythmic gene frequency (frq), and the constitutively expressed genes white collar-1 (wc-1) and white collar-2 (wc-2) ...
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ISOLATION OF CIRCADIAN CLOCK MUTANTS OF NEUROSPORA CRASSA
... Three mutants of Neurospora crassa have been isolated which have altered period lengths of their circadian rhythm of conidiation.. Each of the mutants segregates as a sing[r] ...
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Transcriptional regulation of the arabidopsis circadian clock component LHY
... G-box The effects of the Figure 5.8: mutations on reporter expression Average expression levels were determined for each construct over a period of 120 hours in constant red light and no[r] ...
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