Circulating cells and calcification: A novel concept
Novel approaches in the detection and characterisation of circulating and micrometastatic tumour cells in epithelial malignancies
... locally advanced disease who had detectable disease using ICC reflected the clinical progression/regression of the disease, which is in agreement with other groups that have studied comparable numbers of patients (Peck ...
323
A novel role of cellular interactions in vascular calcification
... Abstract A series of clinical trials have confirmed the correlation between vascular calcification (VC) and cardiovascular events and mortality. However, current treatments have little effects on the regression of ...
8
A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells
... A biomimetic microsystem reproducing the dynamic CTC metastasis to multiple organs may offer a solution to overcome the disadvantages of animal models, while facilitating the simple, inexpensive, and time-saving ...
12
Membrane Hsp70 — a novel target for the isolation of circulating tumor cells after epithelial-to-mesenchymal transition
... epithelial cells to the migratory mesenchymal state which enables the motility and invasiveness of CTCs and their dissemination to distant sites is associated with a loss in the expression of classical epithelial ...
13
A novel method for downstream characterization of breast cancer circulating tumor cells following CellSearch isolation
... of cells occurred in conjunction with subsequent CellSearch ...of cells resulted in approximately 2000 cells per ...200 cells were applied to 10 individual slides, which were later used in the ...
10
Mutational Analysis of Circulating Tumor Cells Using a Novel Microfluidic Collection Device and qPCR Assay
... wild-type cells (Figure 5), a background far exceeding the median background of below 2000 cells observed in clinical ...target cells (Figure ...
12
Association of a novel circulating tumor DNA next generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer
... this novel ctDNA sequencing platform identified genomic alterations in the vast majority of tested patients, reflecting the genomic heterogeneity of patients with predominantly HR+ ...
8
Rosiglitazone promotes development of a novel adipocyte population from bone marrow–derived circulating progenitor cells
... of circulating free fatty ...these cells is promoted by the TZD ROSI, an insulin-sensitiz- ing ...lowering circulating free fatty acid levels via the mobiliza- tion of BM-derived cells to fat ...
10
Clinical application of circulating tumor cells and circulating tumor DNA in uveal melanoma
... DISCUSSION Our results provide the proof of concept for using blood-based biomarkers for prognosti- cation and routine monitoring of patients with UM. First, we showed that SCNA significant for UM prognostication ...
14
Circulating microRNAs as novel biomarkers for diabetes mellitus.
... immune cells (miR-31, -146a -155, -181a, -199a) or of β-cells (miR-9, ...in circulating levels of this miRNA 52 ...blood cells and measured the expression of specific miRNAs thought to play ...
29
Circulating microRNAs as novel biomarkers for dilated cardiomyopathy
... of circulating miRNAs raises the intriguing speculation that they are taken up by distant cells to regulate their gene ...that circulating miRNAs may indeed function in cell-to-cell communica- tion ...
9
Circulating tumor cells and DNA as liquid biopsies
... other cells in the blood and new high-resolution approaches, including recent microfl uidic platforms, for dissecting the genomes of CTCs and obtaining functional ...provide novel biological insights into ...
11
Nanotechnology for the detection and kill of circulating tumor cells
... the course can be compared with electrophoresis course, which is an efficient and high-throughput separation technology in recent years [49,50]. It is an easy, rapid, and accurate method to separate RNA and tumor ...
10
Circulating tumour cells: insights into tumour heterogeneity
... impractical. Circulating tumour cells (CTCs) rep- resent a potential surrogate for tissue-based can- cer and therefore might provide the opportunity to monitor serial changes in tumour ...these novel ...
7
A novel method to quantify gamma H2AX foci in circulating tumour cells in patients receiving chemotherapy for colorectal cancer
... 176 earlier, CTC counts correlate with clinical outcome in several cancers including breast, prostate, colorectal and lung cancer [290]. Due to the mechanism of action of most anticancer treatments, γ-H2AX accumulates ...
197
Regeneration and calcification in the Spirobranchus lamarcki operculum: development and comparative genetics of a novel appendage
... Tentacle regeneration is not discussed in this work, but nevertheless it has been observed many times after accidental amputation of tentacles during detubing or removal of the operculum. Although in evolutionary terms, ...
230
Circulating hematopoietic stem cells and putative intestinal stem cells in coeliac disease
... This study sheds some light on the dynamics of intes- tinal regeneration following GFD in coeliac patients and offers novel insights for the development of HSC-based treatments against CD. Further studies are ...
9
Quantification of circulating melanoma cells
... The development of an immunomagnetic bead capture assay using antibodies able to effectively bind melanoma cells of all disease stages will provide a suitable method [r] ...
128
Metastasis and circulating tumor cells
... suitable for enumeration[22]. The combination of flow cytometry with a magnetic enrichment step allowed for CTC enumeration down to 1 cell per ml [23]. CTC in peripheral blood of patients with metastatic disease turned ...
11
The molecular detection of circulating tumour cells
... Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell[r] ...
9