Circulating tumour cells
Circulating tumour cells: insights into tumour heterogeneity
... Ideally, tumour heterogeneity would be monitored over time, especially in relation to therapeutic strate- ...impractical. Circulating tumour cells (CTCs) rep- resent a potential surrogate for ...
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Gene expression of circulating tumour cells in breast cancer patients
... Materials and Methods: We performed realtime-PCR and multiplex-PCR analyses following immunomag- netic separation of CTC. Peripheral blood (PB) sam- ples of 63 patients with breast cancer of various stages were analyzed ...
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Gene expression of circulating tumour cells and its correlation with tumour stage in breast cancer patients
... Even though new developments in clinical research on breast cancer (BC) have provided clinicians with a set of important diagnostic tools, there is still an urgent need for further, more sensitive staging techniques. Re- ...
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Impact of label-free technologies in head and neck cancer circulating tumour cells
... Keywords: circulating tumour cells, head and neck cancers, label free capture, metastasis, CellSearch ® Received: July 22, 2016 Accepted: August 31, 2016 Published: September 16, 2016 ABSTRACT ...
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Circulating tumour cells and EpCAM as tools for diagnostic and mechanistic studies of lung cancer
... of circulating tumour cells (CTCs) in recent ...rare cells of tumour origin, accounting for 1 in 10 5 to 10 7 mononuclear cells in the blood of a cancer ...of cells, the ...
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Inertia based microfluidic capture and characterisation of circulating tumour cells for the diagnosis of lung cancer
... Correspondence to: Eric Lim. Imperial College and Academic Division of Thoracic Surgery, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK. Email: [email protected]. Background: Routine clinical application of ...
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Phenotypic diversity of circulating tumour cells in patients with metastatic castration‐resistant prostate cancer
... cancer cells from primary sites into circulation and seeding of metastases is the underlying cause of mortality for most non-hematopoietic ...of circulating tumour cells (CTCs) is associated ...
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Heterogeneous expression of EPCAM in human circulating tumour cells from patient-derived xenografts
... occult circulating tumour cells in the peripheral blood and has the potential to identify novel CTC markers using PDX ...used. Tumour DNA content is more stable than RNA content, thus in ...
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Markers of circulating tumour cells in the peripheral blood of patients with melanoma correlate with disease recurrence and progression
... Follow this and additional works at: https://ro.ecu.edu.au/ecuworks2013 Part of the Hematology Commons 10.1111/bjd.12057 This is the pre-peer reviewed version of the following article: Reid, A. L., Millward, M., Pearce, ...
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Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients
... = circulating tumour cells; FITC = fluorescein ...CTCs: circulating tumour cells; DMEM: Dulbecco ’ s modified Eagle ’ s medium; DTCs: disseminated tumour cells; ...
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Isolation and detection of circulating tumour cells from metastatic melanoma patients using a slanted spiral microfluidic device
... ABSTRACT Circulating Tumour Cells (CTCs) are promising cancer ...melanoma cells of over 80% and 55%, after one or two rounds of enrichment, ...blood cells was achieved with one or two ...
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The molecular detection of circulating tumour cells
... Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell[r] ...
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Molecular Analysis of Circulating Tumour Cells in Pancreatic Cancer
... solid tumour material (albeit that the sequence data on the tissue at the corresponding sites was in most cases ...as circulating free DNA (cfDNA) found in plasma: although by pelting the cells ...
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Biomarkers characterization of circulating tumour cells in breast cancer patients
... 50 cells) from two human BC cell lines, MCF-7 and SKBR3, and with low level control numbers (10 and 5 cells and 1 cell) from four human BC cell lines: MCF-7, SKBR3, MDA- MB231, and ...T47D. Cells ...
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Recent advances in the biology of human circulating tumour cells and metastasis
... GBM cells from any other blood cell, CTCs were found in 13/33 patients with ...primary tumour and predominantly at the invasive edge of the deep white matter tracts, the area of the tumour that is ...
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Characterisation of circulating tumour cells in men with advanced prostate cancer and correlation with numbers of circulating and tissue based inflammatory cells
... of circulating platelets and a consequently greater tendency for platelets to cloak their ...and circulating platelet numbers in men who are overweight and of normal weight respectively does provide ...
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Circulating tumour cells in patients with urothelial tumours: Enrichment and in vitro culture
... eter and volume than other hematological cells found in the circulation. We used size-based separation because the most important advantage of filtration methods is the pos- sibility to enrich “virgin CTC.” During ...
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Genetic markers in circulating tumour cells as a measure of the metastatic propensity of uveal melanoma
... risk, tumour biopsy is only occasionally ...of tumour tissue through an invasive procedure, combined with the current lack of effective therapies precludes many patients from consenting to the ...of ...
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Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: A pilot study
... DISCUSSION Detectable CTCs have shown implications for disease-free survival, overall survival, risk of local reoccurrence and risk of metastases in subgroups of other solid tumour groups [15]. However no studies ...
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Phenotypic diversity of circulating tumour cells in patients with metastatic castration-resistant prostate cancer.
... requires cells to contain a 4 0 ,6-diamidino-2-phenylindole positive (DAPI)-intact nucleus, lack expression of the haematopoietic marker CD45, express epithelial cell adhesion molecule (EpCAM) and cytokeratin ...
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