cis-regulation
Molecular Dissection of the 5′ Region of no-on-transientA of Drosophila melanogaster Reveals cis-Regulation by Adjacent dGpi1 Sequences
... The nonA gene of Drosophila melanogaster is important for normal vision, courtship song, and viability and lies ⵑ350 bp downstream of the dGpi1 gene. Full rescue of nonA mutant phenotypes can be achieved by ...
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Effects of BRCA2 cis regulation in normal breast and cancer risk amongst BRCA2 mutation carriers
... Next we aimed to dissect the genetic cis -regulation responsible for the haplotype differences in the expres- sion level of BRCA2 . We performed a series of in silico, in vitro (Figure 3) and in vivo ...
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Conserved non coding elements and cis regulation: actions speak louder than words
... and cis regulation is context and stage ...gene regulation may not be required outside of the phylotypic stage and so highly conserved regions are less likely to be functional at other times, and ...
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Cis regulation of IRF5expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines
... We have analysed how well models in which only func- tional polymorphisms were included accounted for the expression data (Figure 4). Models including the exon 6 indel were clearly inferior and are not shown, given the ...
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Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic
... Therefore, we further performed the annotation and enrichment analysis of cis-regulatory sites that are related to aberrant DNA methylation regions. DNA methylation can result in conformational changes of DNA in ...
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Segregating Variation in the Transcriptome: Cis Regulation and Additivity of Effects
... of cis and trans regulation differ between chromosomes, and particularly if they differ between sex chromosomes and autosomes, our results would not be representative of sex-linked ...of regulation, ...
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Evolution of cis regulation of the proneural genes
... upstream of ac and 31kb upstream of sc (Garcia-Garcia et al. , 1999; Gomez-Skarmeta et al. , 1995). The trans-activator Pannier binds directly to the DNA sequences of the dorsocentral en- hancer, but, through its ...
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Bader, Daniel Magnus (2017): Consequences of DNA variation on gene regulation and human disease via RNA sequencing. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... distant regulation by ...identify cis-regulation, since the two alleles in a hybrid are subject to the same trans ef- ...into cis and trans ...local regulation they selected 77 genes ...
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wtest: an integrated R package for genetic epistasis testing
... Step 2. Testing by the W-test. The wtest() evaluates main and second order interaction and wtest.high() eval- uates third or higher order interaction in genotype data. The wtest.snps.meth() calculates SNP-CpG ...
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LncGPR107 drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner
... LncRNAs were recognized as the byproduct of RNA polymerase II, while, their critical roles emerge recently. Several lncRNAs regulate the transcription activation in cis. For example, lncTCF7 recruits SWI/SNF ...
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Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells
... this regulation of scd1 mRNA has not been observed in mouse adipocytes (3T3-L1) or human hepatocarcinoma cells (HepG2) highlighting a scd1 regu- lation way by OA depending on the cell type (Bene et ...the ...
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Evidence for Redundancy But Not trans Factor-cis Element Coevolution in the Regulation of Drosophila Yp Genes
... DNA elements known to be functional and capable of Tissue- and sex-specific expression: Having found D. binding defined transcription factors in D. melanogaster. grimshawi YPs within D. melanogaster ovaries we addressed ...
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The cis,cis proline isomer of ceratospongamide
... containing peptides, ascidiacyclamides (Ishida et al. , 1988). The backbone is turned at two Pro residues (Fig. 2), and their cis -forms is important in this folded ring. The Thz ring and amide bond plane ...
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Direct regulation of knot gene expression by Ultrabithorax and the evolution of cis regulatory elements in Drosophila
... To better understand how UBX regulates morphology, we would ideally like to know all target genes on which it acts and the DNA regulatory sequences through which it exerts this control. Characterization of these ...
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Regulation of NADP-Malic Enzyme in the Eye-Antennal Disc of D. melanogaster/D. simulans Hybrids: Evidence for cis- and trans-Regulation
... level of activity. ME is apparently functional as a tetramer, so that t he enzyme is composed of sim and me1 homotetrameres as well as heterotetrameres rep- resenting[r] ...
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Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential
... mL Cis (1.43 mg/mL Cis) (Nippon Kayaku ...of Cis with 1 mL DM. Initially we titrated Cis slowly into DM and followed this procedure with 7-day incubation at 37 ° ...unconjugated Cis. ...
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MicroRNA-derived network analysis of differentially methylated genes in schizophrenia, implicating GABA receptor B1 [GABBR1] and protein kinase B [AKT1]
... Conclusions: We find that GABBR1 has a central importance in schizophrenia, even if no direct cause and effect have been shown for it for the time. In addition to being a hub in microRNA-derived regulatory pathways and ...
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Differential trypanosome surface coat regulation by a CCCH protein that co-associates with procyclin mRNA cis-elements
... the cis-acting control sequences for procyclin mRNAs are very well characterised [14–17], protein factors that recognise these regulatory domains have remained unidentified, despite considerable ...and ...
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Why Chinese international students gamble: behavioral decision making and its impact on identity construction
... This article explores the decision making processes involved when Chinese international students’ (CIS) decide whether or not to gamble, as well as the impact that such behavior have on the construction of their ...
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Concurrent profiling of indole-3-acetic acid, abscisic acid, and cytokinins and structurally related purines by high-performance-liquid-chromatography tandem electrospray mass spectrometry
... It is important to resolve CK isomers because these compounds have identical precursor/product ions that cannot be deciphered using MS, and, if not resolved, can result in biased CK quantification [40]. Similarly, many ...
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