Cisplatin(DDP) sensitivity
<p>Silibinin restores the sensitivity of cisplatin and taxol in A2780-resistant cell and reduces drug-induced hepatotoxicity</p>
... 23 Cisplatin, sometime combine with taxol, is widely used in the treatment of advanced ovarian ...of cisplatin with or without taxol would result in drug resistance and strong hepatotoxicity, of which ...
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RESISTANCE AND SENSITIVITY; COMPETITIVE MECHANISMS OF CISPLATIN
... In addition to JNK in p53 dependent apoptosis, it also induces p53 independent cell death by activating p73. JNK forms a complex with p73; any mutation in the binding site reduces the cisplatin sensitivity. ...
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Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy
... and cisplatin, but CDI analysis indicated a modest synergistic ...drug sensitivity of recipient cells in various cancer models via transferring miRNAs or ABC proteins [29, ...
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LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis
... cells were treated with DDP. miR-21-5p overexpression dramatically restored MEG3-induced cell dysfunction in A549-DDP cells, including growth blockage and apoptosis enhancement. In addition, miR-21-5p ...
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Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549)
... to DDP were further ...g/ml DDP was increased by approximately ...μg/ml DDP (P < ...with DDP showed no signifi- cant difference compared with that of mock A549 cells treated with DDP ...
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<p>lncRNA <em>FOXD2-AS1</em> confers cisplatin resistance of non-small-cell lung cancer via regulation of miR185-5p–SIX1 axis</p>
... of DDP-resistant NSCLC ...ferred sensitivity of drug-resistant breast cancer cells to ...Enhanced sensitivity of hepatoma cells to paclitaxel has been con fi rmed to be attributable to the inhibition ...
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RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistant lung cancer cells
... cellular sensitivity to cross-linking ...the sensitivity of A549 cells to cisplatin between knockdown of FANCF and ...that cisplatin-induced DNA cross-links might be repaired by FANCF and ...
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<p>GRHL2 Upregulation Predicts a Poor Prognosis and Promotes the Resistance of Serous Ovarian Cancer to Cisplatin</p>
... the sensitivity of cisplatin-toler- ant cells and its parental cell to DDP in nude ...(Day12). DDP was administered using intraperitoneal injection at a dose of ...After DDP therapy, a ...
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MiR-1244 sensitizes the resistance of non-small cell lung cancer A549 cell to cisplatin
... Background: Cisplatin (DDP)-based chemotherapy is the mainstay of first-line therapy for lung ...in cisplatin (DDP)-resistant non-small cell lung cancer (NSCLC) A549 ...both ...
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NMR studies of the relationship between the changes of membrane lipids and the cisplatin-resistance of A549/DDP cells
... binding cisplatin at physiological concentration [23–25] and di- rect reaction between GSH and cisplatin in cells had been reported ...hance cisplatin sensitivity in some cell lines [27,28], ...
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Original Article Inhibition of beclin1 affects the chemotherapeutic sensitivity of osteosarcoma
... to cisplatin for both MG63 and MG63/ DDP cells in vitro and in ...the sensitivity to anticancer drugs in various kinds of cancers [11, ...chemotherapeutic sensitivity of cispl- atin to ...
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MiR-31 regulates the cisplatin resistance by targeting Src in gallbladder cancer
... increased sensitivity to 5-FU and inhibited cell migration and invasion in colon cancer ...in DDP-resistant GBC ...to DDP both in vitro and in ...
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<p>Exosome-Delivered c-Met siRNA Could Reverse Chemoresistance to Cisplatin in Gastric Cancer</p>
... processes. 36 The resistance to inhibitor of EGFR (AC0010) could be overcome by targeting c-Met. 37 Exosomes are low- immunogenic and low-toxic vesicles secreted by various cell types and could carry proteins, nucleic ...
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Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway
... and its downstream target genes HO-1, NQO1, and GST in HepG2/DDP cells was significantly higher than that in HepG2 cells. The expression level of Nrf2-mediated path- way showed a decrease in Nrf2 siRNA-transfected ...
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Gemcitabine as a molecular targeting agent that blocks the Akt cascade in platinum-resistant ovarian cancer
... Ovarian cancer is a major cause of death among patients with gynecological malignancies. There was some im- provement in the survival time following the introduction of platinum (Cisplatin or Carboplatin) and ...
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The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-κB signaling pathway
... in cisplatin-resistant ovarian cancer and associated with ovarian cancer ...enhanced cisplatin resistance, but GOLPH3L silencing restored the sensitivity of ovarian cancer cells to cisplatin ...
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Original Article Correlation of β-tubulin III and ERCC1 mRNA expression to chemotherapy outcome of gastric cancer patients with malignant ascites
... markers that can be used to predict patient response to chemotherapy. To some extent, variations in genes between patients can enhance or reduce the effectiveness of chemo- therapy. Gene expression levels can therefore ...
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Original Article Overexpression of chromosome kinesin protein KIF4A enhance cisplatin resistance in A549/DDP cells
... Abstract: Cisplatin-based chemotherapy is the most effective method for treating lung cancer currently; however, cisplatin resistance in lung cancer cells has become a major obstacle to the successful ...
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<em>Lycium barbarum</em> polysaccharide prevents cisplatin-induced MLTC-1 cell apoptosis and autophagy via regulating endoplasmic reticulum stress pathway
... and/or DDP for 48 hours and harvested for western blotting ...M DDP exerted the opposite effect on these proteins (Figure ...Meanwhile, DDP-induced p-PERK, p-elF2 α , and ATF4 upregulation were ...
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Ku80 is highly expressed in lung adenocarcinoma and promotes cisplatin resistance
... The heterodimeric Ku antigen, which acts as a mo- lecular detector of DNA double strands, consists of two subunits of 70 kDa (Ku70) and 80 kDa (Ku80 or Ku86) and activate DNA protein kinase (DNA-PK) by binding directly ...
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