Cl− channel
Activation of volume-sensitive Cl channel mediates autophagy- related cell death in myocardial ischaemia/reperfusion injury
... channel-activated causes large amounts of chloride ions outflows lead to intracellular acidification, the acidic environment violently increase autophagic levels, which aggravates the depleting of LAMP2. ...
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A Cl channel activated by parathyroid hormone in rabbit renal proximal tubule cells
... active Cl- conductance in the renal proximal convoluted tubule, although single channel conductance and regulation were not ...the Cl- channel in proximal convoluted tubules by patch clamp ...
9
A maxi Cl(−) channel in cultured pavement cells from the gills of the freshwater rainbow trout Oncorhynchus mykiss
... maxi channel closure in human T1 lymphocytes in response to voltage jumps is best viewed not as classical inactivation, but rather as ...restores channel activity in ...the channel in the open state ...
12
Cl absorption across the thick ascending limb is not altered in cystic fibrosis mice A role for a pseudo CFTR Cl channel
... CTAL Cl 2 channel. Our re- sults indicate that the 9-pS CTAL Cl 2 channel is distinct from ...the channel, notably stimulation by ATP, PKA, and pyrophosphate, strongly suggest a struc- ...
9
Development of selective blockers for Ca2+-activated Cl- channel using Xenopus laevis oocytes with an improved drug screening strategy
... 32.3 PM (NPPB), 94.3 PM (9-AC), 37.3 PM (niflumic acid) and 35.4 PM (flufenamic acid), whereas previously reported values are 48 PM, 28–68 PM, 10.3 PM, 17 PM and 28 PM, respectively (see Table 1). Blocking effect of each ...
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CFTR Cl– channel functional regulation by phosphorylation of focal adhesion kinase at tyrosine 407 in osmosensitive ion transporting mitochondria rich cells of euryhaline killifish
... of Cl – secretion in Fundulus entering seawater, ...CFTR Cl – currents in Xenopus oocytes (Sato et ...based Cl – secretion by killifish opercular ...
13
Increased human Ca2+-activated Cl-channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients
... In this study, to examine a role for CLCA1 in COPD and a mechanistic link between smoking and mucus over- production, we compared the CLCA1 mRNA expression levels in induced-sputum cells[r] ...
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Chloride channels in apical membrane patches of stellate cells of Malpighian tubules of Aedes aegypti
... on channel activity was not studied. A maxi-Cl − channel was never ...Instead, Cl − channels of moderate and low conductance were ...I Cl − channels suggests a possible role in ...
12
Transgenic animals may help resolve a sticky situation in cystic fibrosis
... Cystic fibrosis (CF) is caused by defects in the CFTR, a cAMP-activated Cl – channel of epithelia. The resulting reduction in epithelial fluid transport creates abnormally viscous secretions from airway ...
5
A central role for P2X7 receptors in human microglia
... cationic channel and medi- ator of cellular permeabilization in cultured primary hu- man ...unspecified Cl − channel. Activation of the Cl − channel responsible for dye uptake is ...
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Adenosine regulates a chloride channel via protein kinase C and a G protein in a rabbit cortical collecting duct cell line
... cyclohexyladenosine (CHA) activated the channel in cell-attached patches. Phorbol 12,13- didecanoate and 1-oleoyl 2-acetylglycerol, activators of protein kinase C (PKC), mimicked the effect of CHA, whereas the PKC ...
9
Functional characterization of a voltage gated anion channel from teleost fish intestinal epithelium
... Discussion The goby basolateral membrane union channel is unlike the Cl~ channel in other epithelia At least three pathways for chloride exit exist in the basolateral membrane of teleost[r] ...
22
SLC26A9 mediated chloride secretion prevents mucus obstruction in airway inflammation
... underlying Cl – secretion and its relevance in asthma pathophysiology remain ...(SLC26A9) Cl – channel in asthma, we induced Th2-mediated inflammation via IL-13 treatment in wild-type and ...
7
Molecular Physiology of an Extra-renal Cl- Uptake Mechanism for Body Fluid Cl- Homeostasis
... The present study utilized a comparative ge- nomics approach to show that the three zebrafish CLC-2 genes are located in genomic regions that may share a common evolutionary history (Fig. S2). Our in silico analyses ...
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Molecular Structure, Electronic Structure, Properties and Analyses of Five Azopyridine Ruthenium Complexes α Cl, β Cl, γ Cl, δ Cl and ε Cl of RuCl2(4,6 Dimethyl Phenylazopyridine)2 as Potential Cancer Drugs: DFT and TD DFT Investigations
... ractions between LP(N) with LP*(Ru) and LP(Cl) with LP*(Ru) stabilize the molecular structure. In addition, NBO also shows that the five d orbitals dege- nerated in metal alone are completely separated, since they ...
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Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT3 A receptor
... if Cl-indole modulates receptor desensitisation, we tested the effect of Cl-indole on the rate of receptor desensitisation evoked by prolonged receptor ...of Cl-indole (10 μM) did not alter the ...
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PolyU at CL SciSumm 2016
... Abstract. This document demonstrates our participant system PolyU on CL- SciSumm 2016. There are three tasks in CL-SciSumm 2016. In Task 1A, we apply SVM Rank to identify the spans of text in the reference ...
7
Regulation of mesangial cell ion channels by insulin and angiotensin II Possible role in diabetic glomerular hyperfiltration
... thapsigargin in cell-attached patches, and less sensitive to [Ca2+]i in excised patches. GMC also contained 27-pS nonselective cation channels (NSCC) stimulated by AII, thapsigargin, or [Ca2+]i, but again only when ...
12
Three-Dimensional Continuum Simulations of Ion Transport Through Biological Ion Channels: Effect of Charge Distribution in the Constriction Region of Porin
... As mentioned in the previous section, the distribution of permanent charge around each amino acid is obtained from quantum chemistry calculations that treat each amino acid as a free entity in solution. The dielectric ...
6
Cystic fibrosis and estrogens: a perfect storm
... Irreversible destruction and widening of the airways due to acquired infec- tions or genetic mutations as well as those of unknown cause are more severe in females. Differences between male and female anatomy, behavior, ...
5