CLASS-I MOLECULES
Structural and Functional Dissection of Human Cytomegalovirus US3 in Binding Major Histocompatibility Complex Class I Molecules
... MHC class I ...MHC class I ...MHC class I molecules is not a simple linear sequence but rather is embod- ied in the tertiary structure of the luminal and transmembrane ...
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Human Cytomegalovirus-Encoded Immune Modulators Partner To Downregulate Major Histocompatibility Complex Class I Molecules
... the class I molecule, and the trimeric class I complex is competent to egress toward the cell ...the class I molecule through a tran- sient interaction for several hours until ...
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Quantification of HLA class I molecules on renal cell carcinoma using Edman degradation
... HLA class I molecules, which are necessary for antigen pre- sentation to cytotoxic T cells ...HLA class I complexes on the cell surface that leads to T cell activation has still not ...
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The orthology of HLA-E and H2-Qa1 is hidden by their concerted evolution with other MHC class I molecules
... MHC class I molecules is known to be involved with interactions with the pep- tide-loading machinery; position 222 is involved in inter- actions with tapasin [47] and position 227 with calreticulin ...
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Downregulation of Major Histocompatibility Complex Class I Molecules by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Proteins
... of class I molecules by K3 and ...MHC class I molecules by accelerating their endocytosis (9, ...of class I mol- ecules, we used an immunofluorescence-based ...
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Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells
... (MHC) class I molecules present antigenic peptides to cytotoxic T ...MHC molecules are regulated by several mechanisms including lipopolysaccharide (LPS) and interferon gamma ...MHC I ...
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Possible Assortment of a1 and a2 Region Gene Segments in Human MHC Class I Molecules
... MHC class I molecules, we have constructed triangular tables to study the similarities and differences of various a1 (exon 2) and a2 (exon 3) region ...MHC class I molecules, ...
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Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability
... To study the relation between dissociation of peptides bound to MHC class I molecules and their ability to induce a CTL response, we used nine peptides derived from HBV[r] ...
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Zika Virus Escapes NK Cell Detection by Upregulating Major Histocompatibility Complex Class I Molecules
... FIG 3 Zika virus-mediated upregulation of MHC class I molecules is recapitulated in the A549 cell model and in primary human foreskin fibroblasts (HFF). (A) Zika virus mRNA levels in mock-infected and ...
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Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV 1 infection
... HLA class I molecules can also occur as soluble agents in the serum or plasma ...HLA class I molecules can either occur as intact, 44-kDa HLA class I heavy chains, ...
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A Human Herpesvirus 7 Glycoprotein, U21, Diverts Major Histocompatibility Complex Class I Molecules to Lysosomes
... MHC class I molecules to ...of class I mole- cules complexed with ...Ab. Class I immunolabeling of control astrocytoma cells shows a typical plasma membrane labeling ...
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Downregulation of MHC class I molecules by human cytomegalovirus-encoded US2 and US11
... MHC class I locus products. At present, the domains of the class I heavy chains that are important for binding to US11, or that determine their sensitivity to US11-mediated dislocation and ...
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Murine cytomegalovirus interacts with major histocompatibility complex class I molecules to establish cellular infection.
... 4182-4189 0022-538X/93/074182-08$02.00/0 Copyright X 1993, American Society for Microbiology JOURNAL OF VIROLOGY, Murine Cytomegalovirus Interacts with Major Histocompatibility Complex C[r] ...
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Role of the adenovirus E3-19k conserved region in binding major histocompatibility complex class I molecules.
... 4778-4783 0022-538X/92/084778-06$02.00/0 Copyright © 1992, American Society for Microbiology Role of the Adenovirus E3-19k Conserved Region in Binding Major Histocompatibility Complex Cl[r] ...
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Murine Cytomegalovirus Perturbs Endosomal Trafficking of Major Histocompatibility Complex Class I Molecules in the Early Phase of Infection
... MHC-I molecules are constitutively internalized via Arf6- associated clathrin-independent endocytic carriers that fuse with EEA1-positive transferrin-containing endosomes gener- ated by clathrin-dependent ...
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Involvement of human leukocyte antigen class I molecules in human immunodeficiency virus infection of CD4-positive cells.
... Questioning the exact roles of virus-associated MHC-I molecules and cell surface-expressed MHC-I molecules during the HIV life cycle became urgent, particularly in light of the debate su[r] ...
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Functional characterisation of HLA-F
... the class II ...MHC class II molecules HLA-DR, - DP and ...as class II ...the class II region. The class III region encodes proteins of the complement system and other proteins ...
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Human Herpesvirus 7 U21 Tetramerizes To Associate with Class I Major Histocompatibility Complex Molecules
... of class I MHC molecules to lysosomes, the simplest is one exemplified by the MCMV m06 immunoevasin ...m06-class I MHC complex to the lysosomal compartment ...of class I ...
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Bhonsle, Latika (2012): Characterization of potentially autoaggressive brain infiltrating CD8+ T cells in multiple sclerosis patients. Dissertation, LMU München: Fakultät für Biologie
... Various proteins are implicated in the immune pathogenesis of experimental autoimmune encephalitis (EAE), the animal model of MS. For example myelin oligodendrocyte protein (MOG) (Schluesener et al. 1987), myelin basic ...
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HLA class I deficiencies due to mutations in subunit 1 of the peptide transporter TAP1
... HLA class I molecules. Three cases of HLA class I deficiency have previ- ously been shown to result from the absence of a functional TAP2 ...HLA class I deficiency but ...
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