Class II Major Histocompatibility complex
Efficient Class II Major Histocompatibility Complex Presentation of Endogenously Synthesized Hepatitis C Virus Core Protein by Epstein-Barr Virus-Transformed B-Lymphoblastoid Cell Lines to CD4+ T Cells
... MHC class II molecules with endogenous peptides (25, 28, 36), and they might be in- volved in the hydrolytic digestion of endogenous HCV poly- peptides and the consequent binding of processed peptides with ...
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Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins.
... class I 1 II 2 MC57G target cells were scored as positive. The addition of recom- binant IL-2 optimizes this in vitro system, but the frequency of the CTLp de- tected depends on the extent of clonal ...
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A Novel Bat Herpesvirus Encodes Homologues of Major Histocompatibility Complex Classes I and II, C-Type Lectin, and a Unique Family of Immune-Related Genes
... encode major histocompatibility complex (MHC)-related proteins, 2 to encode MHC class I homologues, and 3 to encode MHC class II homologues; 4 encode the homologues of C-type ...
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A defect in the regulation of major histocompatibility complex class II gene expression in human HLA DR negative lymphocytes from patients with combined immunodeficiency syndrome
... Patients with an autosomal recessive combined immunodeficiency are characterized by an HLA negative phenotype of activated T and B lymphocytes. To determine the molecular basis of this syndrome we have studied the ...
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Genomic organisation and transcript identification in the class II region of the human major histocompatibility complex
... and class II expression, were transfected with varying length constructs of li and labelled with rabbit anti-Ii antibody (Bakke and Dobberstein, ...directs class Il/Ii complexes to ...
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Impairment of monocytic function during Trypanosoma cruzi infection.
... Finally, infected clone 53 showed a decreased ability to present antigen to major histocompatibility complex-matched T cells, which may relate to the absence of Class II antigens or to a[r] ...
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Cytotoxic T-Lymphocyte Precursor Frequencies in BALB/c Mice after Acute Respiratory Syncytial Virus (RSV) Infection or Immunization with a Formalin-Inactivated RSV Vaccine
... study, major histocompatibility complex (MHC) class I- and II-restricted, RSV-specific cytotoxic T-lymphocyte precursor (CTLp) frequencies were determined in bronchoalveolar lavage ...
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Phenotypic changes in Langerhans' cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection?
... of major histocompatibility complex class I and II antigens (4, 22, 25) and the accessory and costimulatory molecules intra- cellular adhesion molecule-1–CD54, CD11a, CD18 (6, 21), and ...
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CD200 fusion protein decreases microglial activation in the hippocampus of aged rats
... including major histocompatibility complex Class II (MHCII) and CD40 mRNA, as well as MHCII immunoreactivity, were increased in hippocampus of aged, compared with young, rats and that ...
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Gains and Losses of HLA Class II (DR) and CD4 in Atypical Hyperplasia, Carcinoma in situ and Infiltrating Ductal Carcinoma of the Breast
... of major histocompatibility complex (MHC) class II (HLA-DR) on atypical and malignant primary mammary epithelial cells, as well as the magnitude of the stromal T lymphocytes (T4 subset) ...
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Roles of Major Histocompatibility Complex Class II in Inducing Protective Immune Responses to Influenza Vaccination
... cells, 2.2 ⫻ 10 7 enriched CD43 ⫹ cells, or 3.3 ⫻ 10 7 enriched CD43 ⫺ cells derived from wild-type mice (Fig. 7A). The groups of MHC-II KO mice that received adoptive transfer with a fraction of CD4 ⫹ , CD43 ⫹ , ...
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T-Cell Vaccination Alters the Course of Murine Herpesvirus 68 Infection and the Establishment of Viral Latency in Mice
... a major health concern, and there is significant interest in developing vaccines against this class of viral ...for class I- and class II-restricted epitopes on the acute phase of the ...
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Functional Macroautophagy Induction by Influenza A Virus without a Contribution to Major Histocompatibility Complex Class II-Restricted Presentation
... Several factors may limit the utility of autophagy for class II-restricted epitope generation. Although largely considered a nonselective pathway of protein degradation, recent data sug- gest that the ...
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Binding of Human Cytomegalovirus US2 to Major Histocompatibility Complex Class I and II Proteins Is Not Sufficient for Their Degradation
... MHC class I HC and class II DR- ␣ ...MHC class I HC and class II DR-␣ were ...MHC class I HC or class II DR-␣ proteins were immunoprecipitated from cell ...
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Progress in spondylarthritis Progress in studies of the genetics of ankylosing spondylitis
... Major histocompatibility genes other than HLA-B There is strong evidence from studies of association of other MHC class II and class III genes with AS for the existence of other ...
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Arthritogenic T cell epitope in glucose 6 phosphate isomerase induced arthritis
... the major histocompatibility complex (MHC) class II (I-Aq) from DBA/1 mice was identified from the amino acid sequence of T cell epitopes and candidate peptides of T cell epitopes in ...
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Modified Vaccinia Virus Ankara-Infected Dendritic Cells Present CD4+ T-Cell Epitopes by Endogenous Major Histocompatibility Complex Class II Presentation Pathways
... First, we analyzed whether autophagy is induced upon MVA infection in BMDCs. LC3 is a biochemical marker for this path- way, and the conversion of the cytosolic 18-kDa LC3-I to the membrane-bound 16-kDa LC3-II ...
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Cells of the synovium in rheumatoid arthritis T lymphocytes
... epitope major histocompatibility complex class II (MHCII-SE) and peptide on antigen-presenting cells (APCs) either systemically or in the ...
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The Major Histocompatibility Complex in Song Sparrows: Immunity, Signals, and Mate Choice
... Although most research on MHC-mediated mate choice has addressed preferences for MHC-dissimilar mates, in many systems (particularly those in which males provide extensive material benefits to females and offspring, as ...
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<p>Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment</p>
... MHC class II also has been studied in ...MHC class II had been ...MHC class II could be induced by IFN- γ in TKB-3 and TKB-4 cell lines and the induced MHC class II ...
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