CLATHRIN-COATED VESICLES
Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles
... Hepatitis C virus (HCV) is a major human pathogen associated with life-threatening liver disease. Entry into hepatocytes requires CD81 and a putative second receptor. In this study, we elucidated the postreceptor ...
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Auxilin is required for formation of Golgi derived clathrin coated vesicles during Drosophila spermatogenesis
... of clathrin function is auxilin, first identified in mammals as a cofactor in Hsc70-mediated disassembly of clathrin coats from nascent clathrin-coated vesicles (CCVs) in vitro ...
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Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6
... A novel role for rab5 in AP2 uncoating Rab5 has been shown to generate specifi c membrane domains that are important for its cellular functions, such as endosome fusion and signaling ( Zerial and McBride, 2001 ). The ...
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Transcriptomic analyses reveal clathrin-mediated endocytosis involved in symbiotic seed germination of Gastrodia elata
... of clathrin-coated vesicle formation (Doherty and McMahon 2009; McMahon and Boucrot ...2011). Clathrin-mediated endocytosis initiates at the plasma membrane with the recruitment of ...including ...
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Structure, mechanism and regulation of the clathrin coated vesicle and yeast vacuolar H(+) ATPases
... in clathrin-coated vesicles are involved in such processes as receptor-mediated endocytosis, intracellular membrane trafficking and neurotransmitter uptake, while those in yeast function in protein ...
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Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.
... of clathrin-coated pits, and impairs the endocytosis of many cargo proteins [17] ...of coated pits, and most studies have found little or no effect on the rate of endocytosis of ‘‘standard’’ cargo ...
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Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor mu 2 kinase
... formed coated pits (Olusanya et ...in clathrin-coated vesicles budding from the TGN, also enhances its association with cargo (Ghosh and Kornfeld, ...
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Hung_unc_0153D_16343.pdf
... intracellular clathrin coated ...the vesicles in EpsinR knocksideways cells, many other coat accessory proteins and luminal proteins are ...other clathrin adaptors for their traffic are also ...
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An Investigation into the Physiological Role of Annexin A11
... Annexin A 6 has also been localised to a range o f endosomal membranes in different cell types, including the plasma membrane and clathrin-coated vesicles, where.. it could [r] ...
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Uptake of Helicobacter pylori Vesicles Is Facilitated by Clathrin Dependent and Clathrin Independent Endocytic Pathways
... of clathrin-coated vesicles (9), and dynamin ...of vesicles and Tfn was quantified with the qIS ...of vesicles by 37% and uptake of Tfn by 65% ...pylori vesicles increases over ...
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A PLANT BIOCHEMIST'S VIEW OF H+ ATPases AND ATP SYNTHASES
... The treatment of yeast, Neurospora crassa, or oat root vacuolar membranes and clathrin-coated vesicles with KI or KNO3 in the presence of Mg 2+ -ATP rapidly inactivates ATPase activity a[r] ...
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Evidence for a conserved 95 120 kDa subunit associated with and essential for activity of V ATPases
... Vphlp has 4 2 % identity to the 116 kDa polypeptide of the rat clathrin-coated vesicles/synaptic vesicle proton pump, 4 2 % identity to the TJ6 mouse immune suppressor factor, 4 2 % iden[r] ...
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Disruption of clathrin dependent trafficking results in the failure of grass carp reovirus cellular entry
... For a Western blotting analysis, cells were lysed in the wells with lysis buffer (Thermo Scientific) containing a protease inhibitor cocktail. Protein concentrations were determined with a Bio-Rad protein assay kit. ...
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Nanocarriers for Drug Delivery Applications: From Tunable Morphologies to Glycopolymer-coated Vesicles
... The work described in this thesis presented the synthesis of novel polymeric systems for potential use in drug delivery and other biomedical applications. The development of functional polymeric nanocarriers that are ...
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TRAIL and vitamins: opting for keys to castle of cancer proteome instead of open sesame
... Besides, impairment of endocytosis or disruption of clathrin-dependent endocytosis signaling components (adaptor protein 2 and clathrin) recapitulates cell surface appearance of the deat[r] ...
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VACUOLAR TYPE H+ TRANSLOCATING ATPases IN PLANT ENDOMEMBRANES: SUBUNIT ORGANIZATION AND MULTIGENE FAMILIES
... Proton transport by the bovine coated vesicles is dependent on permeant anions that lead to dissipation of the membrane potential; however, neither ATP hydrolysis nor H + pumping by the [r] ...
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Hsc70 induced changes in clathrin auxilin cage structure suggest a role for clathrin light chains in cage disassembly
... three clathrin heavy chains are ...the clathrin hub with light chain b ...to clathrin coats at equilibrium was determined by Xing et ...the clathrin C-terminus and adjacent to the auxilin J ...
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Clathrin Mediates Infectious Hepatitis C Virus Particle Egress
... by clathrin, AP-1, and dynamin. We first addressed whether clathrin and AP-1 are involved in HCVcc ...of clathrin and AP-1 in HCVcc egress by using Huh7 Lunet N cells (16), into which HCV RNA was ...
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Receptor-Mediated Moloney Murine Leukemia Virus Entry Can Occur Independently of the Clathrin-Coated-Pit-Mediated Endocytic Pathway
... the clathrin-coated pits and for subsequent sort- ing to different stages of cellular trafficking within the cell (34, 42, ...of clathrin-coated ...to clathrin and to some ...
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Effects of age on noninvasive assessments of vascular function in nonhuman primates: implications for translational drug discovery
... membrane coated vesicles) and endothelial progenitor cells (EPCs, a population of cells in the blood involved in endothelial repair), are associated with cardiovascular risk in humans [20,21] and are being ...
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