Claudin-1
Original Article The expression patterns of tight junction protein claudin-1, -3, and -4 in human gastric neoplasms and adjacent non-neoplastic tissues
... parallelly, claudin-7 has also been found to be reduced in invasive breast cancer ...several claudin proteins are often up-regulated in certain ...that claudin-3 and claudin-4 was highly ...
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Claudin 1 regulates cellular transformation and metastatic behavior in colon cancer
... between claudin expression/localization and cancer has not been ...of claudin-1 in human primary colon carcinoma and metastasis and in cell lines derived from primary and metastatic ...of ...
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Differential Expression Pattern of Epithelial Mesenchymal Transition Gens: AXL, GAS6, Claudin-1, and Cofilin-1, in Different Stages of Epithelial Ovarian Cancer
... Table 1 Expression of four target genes (i.e., AXL, GAS6, Claudin-1, and Cofilin-1) was investigated in all tissues by using quantitative real-time re- verse transcription PCR ...
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THE SIGNIFICANCE OF CLAUDIN-1 AND S100A4 EXPRESSION IN PRIMARY COLORECTAL CARCINOMA
... considered claudin-1 positive if any number of tumor cells showed membranous and/or cytoplasmic ...of claudin-1 immunostaining were evaluated in tumor tissue as well as in the concordant ...
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Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry
... of claudin-2, thereby relieving inflammatory diseases caused by the increased expression of claudin-2, such as inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC) (33, ...coreceptors, ...
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Hepatitis C Virus Induces CD81 and Claudin-1 Endocytosis
... proteins claudin-1 and occludin have been identified as essential entry ...and claudin-1 coendocytosis and fusion with Rab5 expressing endosomes, supporting a role for this receptor complex in ...
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The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus
... expressing claudin-1. The entry mediated by claudin-6 was low and detectable only for subtype 1a ...the claudin-9-positive NKNT3 cells, and there was no expression of claudin-9 in the ...
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Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer
... Claudin-1 (CLDN1) is overexpressed in gastric cancer and correlated with tumor invasion, metastasis and poor outcome. Here, we both down and up regulated CLDN1 expression in gastric cancer cells to ...
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Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung
... of claudin-1, claudin-3 and claudin-4 mRNAs in all 23 cases ...of claudin-1 mRNA was low during the pseudo-glandular period, a finding which is concurrent with the results of ...
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Epithelial HIF 1α/claudin 1 axis regulates barrier dysfunction in eosinophilic esophagitis
... Previous work indicated, counter to expectations, that decreased HIF-1α is a result of prolonged experimental hypoxia in epidermal keratinocytes, endothelial cells, lung adenocarcino- ma, and colon cancer cell lines in ...
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Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry
... ABSTRACT Hepatitis C virus (HCV) infection causes 500,000 deaths annually, in as- sociation with end-stage liver diseases. Investigations of the HCV life cycle have wid- ened the knowledge of virology, and here we ...
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Hepatitis C Virus Entry Is Impaired by Claudin-1 Downregulation in Diacylglycerol Acyltransferase-1-Deficient Cells
... Diacylglycerol acyltransferase-1 (DGAT1) is involved in the assembly of hepatitis C virus (HCV) by facilitating the trafficking of the HCV core protein to the lipid droplet. Here, we abrogated DGAT1 expression in ...
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Review Article Clinical significance of claudin-1 in gastric cancer: a meta-analysis
... 20]. Claudin family has been narrowly correlated to the regulation of molecular networks during the formation of tight junctions, which are essential parts of cell adhe- sion [21, ...of claudin isoforms a ...
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CD81 and Claudin 1 Coreceptor Association: Role in Hepatitis C Virus Entry
... Hepatitis C virus (HCV) is an enveloped positive-stranded RNA hepatotropic virus. HCV pseudoparticles infect liver-derived cells, supporting a model in which liver-specific molecules define HCV internalization. Three ...
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Down Regulation of Claudin 1 Expression in Gastric Cancer Mucosa Is Correlated with Poor Prognosis
... of claudin-1 is significantly lower in cases of in- testinal type rather than diffuse type gastric carcinoma ...of claudin immunoreactivities in gastric ...regarding claudin-1 ...
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Antibody targeting of claudin-1 as a potential colorectal cancer therapy
... Spheroids were prepared by plating 1000 DiFi cells per well in ultra-low attachment 96-well plates, and growing them in the presence of 100 μg/ml of the 6 F6 mAb or irrelevant mAb (retuximab) for 5 days. For cell cycle ...
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Role of IL-10 in Hepatocyte Tight Junction Alteration in Mouse Model of Experimental Colitis
... Base on these results we hypothesized that IL-10 plays a role in the modulation of hepatic TJs perselectivity. Cholestasis has been observed in a rat model of IBD induced by intracolonic injection of TNB (30). Our data ...
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Role of tight junction proteins in gastroesophageal reflux disease
... (e.g. Claudin-2, -3, -4, -7 and −18) in Barrett’s metaplasia and carcinogenesis towards esophageal adenocarcinoma ...of Claudin-3 and no change of Claudin-1 and 4 [31,32], while an in vitro ...
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Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial Cells
... Tight junction integrity has typically been assessed using Transepithelial Electrical Resistance (TEER) [18]. Higher resistance measurements are typically observed in conflu- ent polarised cultures with intact junctional ...
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Original Article Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin
... claudins 1, 2, 3, 4, 5 and 7 in a sample set consisting of a total of 93 cases representing normal skin, actinic keratoses and squamous cell carcinomas of the ...in claudin expression. Claudin ...
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