claudin-1 and -2
Comparable mRNA expression of inflammatory markers but lower claudin-1 mRNA levels in foreskin tissue of HSV-2 seropositive versus seronegative asymptomatic Kenyan young men
... Receptor 1(MRC1), IL-1, IL-6, TNF- α , β 7, IgA, IFN- α , CCL5, E-cadherin, ZO-1, occludin and claudin-1 was per- formed by using the ABI PRISM 7700 sequence detec- tion system and ...
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Toll-like receptor 5-mediated IL-17C expression in intestinal epithelial cells enhances epithelial host defense against F4+ ETEC infection
... of claudin-1 and claudin-2 in ETEC infected IPEC-J2 cells were further analyzed by confo- cal ...Both claudin-1 and -2 were increased in ETEC infected IPEC-J2 cells: ...
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The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus
... expressing claudin-1. The entry mediated by claudin-6 was low and detectable only for subtype 1a ...the claudin-9-positive NKNT3 cells, and there was no expression of claudin-9 in the ...
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Claudins in lung diseases
... of claudin 3, occluding and ZO-1 ...claudins 2, 3, 8 and 10 and ZO-1 ...din 1, ZO-1 and occludin from cell membranes along with a decrease in electrical transmembrane potential ...
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THE SIGNIFICANCE OF CLAUDIN-1 AND S100A4 EXPRESSION IN PRIMARY COLORECTAL CARCINOMA
... Normal colonic and rectal mucosa showed negative staining for S100A4 (Figure 5). Ten tumors showed absent (score 0-2), or only mild (score 3) (Figure 6), nine tumors showed moderate S100A4 expression (score 4-5) ...
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Original Article The expression patterns of tight junction protein claudin-1, -3, and -4 in human gastric neoplasms and adjacent non-neoplastic tissues
... The claudin family which are essential for the formation of TJs consists of approximately 27 proteins ...certain claudin may alter normal tight junction structure contributing to the neoplastic ...
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Antibody targeting of claudin-1 as a potential colorectal cancer therapy
... 7.4, 1 mM EDTA, 1 mM EGTA, 1% SDS, 1% Triton X-100, ...NP-40, 2 mM PMSF, 100 mM NaF, 10 mM sodium orthovanadate, one cocktail protease inhibitor tablet for 10 ml) using a Mixer Mill® MM ...
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Snail promotes an invasive phenotype in lung carcinoma
... claudins 1 and 5, and a similar tendency was observed for claudins 3 and ...of claudin 1 mRNA in the SK-MES1 cell line and increased the expressions of claudins 2 and 7 mRNA in the BEAS-2B ...
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Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry
... of claudin-2, thereby relieving inflammatory diseases caused by the increased expression of claudin-2, such as inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC) (33, ...
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Original Article Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia
... This was a cross-sectional study that included 46 anal biopsy specimens. Forty-two biopsies were collected with consent at the Evandro Chagas National Institute of Infectious Di- seases of the Oswaldo Cruz Foundation ...
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Original Article Somatostatin regulates tight junction proteins expression in colitis mice
... and claudin-3 expression significantly decreased compared with the control mice (P < ...treatment, claudin-1 and claudin-3 expression signifi- cantly increased compared with untreated CR ...
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The Protective Effect of Heme Oxygenase-1 against Intestinal Barrier Dysfunction in Cholestatic Liver Injury Is Associated with NF-κB Inhibition
... Heme oxygenase-1 (HO-1) is reported to protect against liver injury, but little is known about its effect on the intestinal barrier in cholestatic liver injury. In this study, we investigated the effects of ...
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Claudin 1 regulates cellular transformation and metastatic behavior in colon cancer
... cells. 2+: cytoplas- mic: staining in 25–50% of cells; membranous: discontinuous staining, 50–75% of cells; nuclear: 25–50% of ...cells. Claudin-1 staining increases with metastasis in patient ...
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Original Article Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin
... of claudin 1 expression was nuclear immunostaining observed in some ...cases. Claudin 1 nuclear location has previ- ously been reported in melanocytic lesions where its translocation was ...
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Hepatitis C Virus Induces CD81 and Claudin-1 Endocytosis
... of 2 g of anti-CD81 2s66/ml after pretreatment with DMSO control (lane 2) or 80 M Dynasore (lane 3) were captured by streptavidin pulldown. Precipitates (P, upper panel) and whole-cell lysates (WCL, ...
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Role of tight junction proteins in gastroesophageal reflux disease
... of Claudin-1 (both on transcript and protein level) was the only significant difference identified between patients with ERD and ...elevated Claudin-1 levels in ERD reflect tissue repair in ...
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A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway
... [16,25]. It interacts with meprin-B, N-copine, DC-STAMP and TRPV4, proteins associated with the endoplasmic reticulum, and plays a role in ER-to-Golgi transport of membrane proteins in mammalian and yeast cells ...
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Differential Expression Pattern of Epithelial Mesenchymal Transition Gens: AXL, GAS6, Claudin-1, and Cofilin-1, in Different Stages of Epithelial Ovarian Cancer
... Numerous pieces of evidence suggest the im- portant function of the cytoskeleton in the EMT (9). Actin cytoskeleton and its interaction proteins are remodeled and are the motive power for cell migrate and invasiveness of ...
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Original Article Expression of claudin-5, -7, -8 and -9 in cervical carcinoma tissues and adjacent non-neoplastic tissues
... for claudin-7 and claudins-9, which showed ...of claudin expres- sion patterns in cancer, it has been suggested that claudins may represent useful molecular markers for many different ...including ...
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Novel Role of MCP-Induced Protein 1 in Ischemic Brain Damage in Animals of Transient Focal Ischemia
... levels of ZO-1 and claudin-5 were significantly lower in Mcpip1-/- mice as compared to 209. that of wild type after 2 hour ischemia followed by 24 hours reperfusion[r] ...
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