Clonal evolution
Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing
... “clonal evolution” refers to tumor progression through stepwise acquisition of new mutations providing genetic diversity within a cell ...show clonal evolution from diagnosis to relapse, ...
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The Genetic Landscape and Clonal Evolution of Breast Cancer Resistance to Palbociclib plus Fulvestrant in the PALOMA-3 Trial.
... of clonal evolution on therapy with loss of ESR1 mutations reflecting loss of the sensitive sub clone (Figure 1C, 1G), with others emerging during subsequent fulvestrant treatment at the same rate and ...
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Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones
... during clonal evolution challenge the concept of non-invasive disease monitoring by quantification of circulating tumor- DNA based on the mutational spectrum of the primary ...
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Clonal evolution of acute myeloid leukemia highlighted by latest genome sequencing studies
... the evolution path because clone 4 only comprised ...Similar clonal evolution was also observed in other seven patients ...Tumor clonal architecture is prevalent in ...
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Breast adenocarcinoma recurring as small cell carcinoma in a patient with a germline BRCA2 mutation: clonal evolution unchecked
... Our findings highlight the potential of longitudinal and serial profiling of tumors to study which events confer resistance or a survival advantage for tumor cells. It also demonstrates how therapy can eliminate dominant ...
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Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B cell lymphomas
... two clonal evolution scenarios of DLBCL ...genetic evolution pattern of this SNV during relapse of patient 1 mir- rored this patient’s V H DJ H clonal evolution ...
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TNF α induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells
... Fancc –/– but not in WT cells. The leukemic clones were TNF-a resistant but retained their characteristic hypersensitivity to mitomycin C and exhibited high levels of chromosomal instability. Expression of FANCC cDNA in ...
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Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments
... Accurate allele frequencies are important for measuring subclonal heterogeneity and clonal evolution. Deep-targeted sequencing data can contain PCR duplicates, inflating perceived read depth. Here we ...
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Clonal Evolution of CD8+ T Cell Responses against Latent Viruses: Relationship among Phenotype, Localization, and Function
... the clonal relationships between hCMV-specific CD8 ⫹ T cells from pretransplantation LN samples and those from PB samples taken at the moment of viral replica- tion in four hCMV-seropositive patients who ...
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Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
... Therefore, as our understanding of myeloma biology increases, information such as mutational load may guide specific treatment modalities in the future. The use of lenalidomide maintenance is one of the first clinical ...
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Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients.
... that clonal structure may be further assessed using single cell analysis, but at present the challenges of obtaining individual malignant plasma cells from large series of patients at multiple disease time points ...
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Myeloid transformation of plasma cell myeloma: molecular evidence of clonal evolution revealed by next generation sequencing
... similar clonal aberrations in the diagnostic plasma cell population and post-therapy neoplastic cells, including IGH-MAF rearrangement, multiple genetic mutations in RAS signaling pathway proteins, and loss of ...
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DNA Macrorestriction Analysis of Nontypeable Group B Streptococcal Isolates: Clonal Evolution of Nontypeable and Type V Isolates
... Group B streptococci (GBS) are serotyped according to capsular polysaccharide (CPS) type (Ia to VIII); an isolate is classified as nontypeable (NT) if no detectable CPS is found. Surface-localized protein antigens ( ␣ , ...
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Clonal Evolution Leading to Maintenance of Antibiotic Resistance Rates among Colonizing Pneumococci in the PCV7 Era in Portugal
... Evolution of characteristics of antimicrobial-resistant pneu- mococci. Figure 1 compares antimicrobial resistance rates over the three time periods. The proportion of antimicrobial-resis- tant pneumococci (defined ...
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Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context
... of clonal selection ...branching evolution, with a ‘trunk’ of shared changes and a series of ‘private’ mutations reflecting continual independent ...
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Measuring cancer evolution from the genome.
... requires evolution to at multiple levels in epithelial tissues[32]: in the example of the colon, first a mutated cell must repopulate the crypt, and then the mutant crypt itself must divide to form a glandular ...
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Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development
... natural clonal evolution or treatment ...investigating clonal dynamics by analyzing transplanted tumors in recipients with altered microenvironmental backgrounds or with a particular ...
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Cancer genomics: one cell at a time
... delineating clonal evolution and diversity in primary tumors [30,34,36,37,45,46], the field has begun to shift towards studying CTCs and their role in metastatic dissemination ...dissemination/parallel ...
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Neutral tumor evolution in myeloma is associated with poor prognosis
... neutral evolution was shown in 20% of tumors (65/333) from the Myeloma XI trial ...neutral evolution was not influenced by sequencing depth, exome coverage or number of mutations (Supplementary Table ...
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spheroids using agas permeable plate and embedded
... Ishikawa cell line during long-term culture: Proposal for an in vitro clonal evolution model of tumor cells.. Organoids in cancer research.[r] ...
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