Cochlear Hair Cells
Tricellulin deficiency affects tight junction architecture and cochlear hair cells
... extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular ...mechanosensory cochlear hair cells, while the ...
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Transduction without Tip Links in Cochlear Hair Cells Is Mediated by Ion Channels with Permeation Properties Distinct from Those of the Mechano-Electrical Transducer Channel
... Our observations show that MET channels in mammalian auditory hair cells can be gated when tip links are removed pharma- cologically or are destroyed by repeated mechanical overstimulation. The currents ...
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The Actin-Binding Proteins Eps8 and Gelsolin Have Complementary Roles in Regulating the Growth and Stability of Mechanosensory Hair Bundles of Mammalian Cochlear Outer Hair Cells
... the hair-like bundles that project from the apical surface of cochlear hair ...cells. Hair bundles show a stair-case structure composed of rows of stereocilia, and each stereocilium ...
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Linear and nonlinear processing in hair cells
... many hair cells sit on the ascending limb, close to the point of maximum ...Mammalian cochlear hair cells make use of the resulting nonlinearity to respond to sounds at high frequencies ...
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Development and Function of the Voltage-Gated Sodium Current in Immature Mammalian Cochlear Inner Hair Cells
... Voltage-gated Na + channels are complexes of an a subunit and, in most cases, auxiliary b-subunits [14–16]. While the a-subunit determines the main properties of the Na + channels (ion permeability and kinetics) the b ...
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TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells
... of cochlear hair cells to convert sound into receptor potentials relies on the mechanoelectrical transducer (MET) channels present in their stereociliary ...outer hair cells, OHCs) ...
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Multiple Quantitative Trait Loci Modify Cochlear Hair Cell Degeneration in the Beethoven (Tmc1Bth) Mouse Model of Progressive Hearing Loss DFNA36
... in cochlear hair cells and colocalizes with Tmc1m1, but we found no strain-specific coding or splice site sequence variants of Tmc2 correlated with the phenotypic effects of Tmc1m1 (not ...in ...
9
EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness
... bipolar cells, ganglion cells, and amacrine cells) and the outer plexiform layer of the retina (consisting of the processes of rods and cones, horizontal cells, and bipolar cells), in ...
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Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells
... endothelial cells and red blood cells where it detects frictional force (sheer stress) (Bae et ...of cochlear hair cells (Liu et ...
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Degeneration of saccular hair cells caused by MITF gene mutation
... intermediate cells were vital in EP and K + transport [25, ...intermediate cells was notable in the SV of albino pigs [5], which would influence endo- lymphatic potential ...the hair cells, ...
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Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells
... Immunoc ytochemical labeling of cells. C ells were characterized with numerous antibodies at 33° and 39°C at approximately the same cell density. C ells were cultured at 33°C for 2–3 d and at 39°C for 2 weeks. ...
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Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200 rich and CD34 positive hair follicle progenitor cells
... (A and B) As assessed by immunohistol- ogy of mouse skin, CD200 was expressed in bulge and secondary hair germ cells (A), whereas CD34 was expressed in bulge cells, but not secondary hair germ ...
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Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape
... sensory cells and supporting cells between embryonic day ...the cochlear duct accompanied by a thinning of the epithelium, during which cell intercalations occur and cell-cell junctions appear or ...
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A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth
... inner hair cells (IHCs) and outer hair cells (OHCs) are organized into a single medial-side row and three lateral-side rows, respectively (left ...A hair bundle that consists of ...
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Tympanic border cells are Wnt responsive and can act as progenitors for postnatal mouse cochlear cells
... stem cells in the gastrointestinal system (Barker et ...progenitor cells are incompletely ...of cochlear progenitor ...characterized cochlear cell population: tympanic border cells ...
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Application of force to the cochlear wall: effect on auditory thresholds, outer hair cell transduction, and distortion product otoacoustic emissions
... outer hair cells, and the coloured circuits are negative feedback loops we’ve identified over the past few years which help the outer hair cells maintain their exquisite auditory sensitivity, ...
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Comparing the cultivated cochlear cells derived from neonatal and adult mouse
... of cells derived from P1 or P60 cochleae, respectively, we still found that the stark loss of capacity for sphere formation in P60 ...sphere-forming cells from dissociated primary ototspheres at ...stem ...
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Identification of Bulge Stem Cells in Mouse and Human Hair Follicles
... of hair growth is thought to be dependent on HF stem cells [4] ...Stem cells located in the HF bulge area give rise to the follicle struc- tures during each anagen phase ...
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Towards a better understanding of cochlear mechanics: A new cochlear model
... The purpose of modelling cochlear mechanics is to gain a better understanding of the operation of the real cochlea by the formulation and analysis of models that reflect the structure an[r] ...
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Inhibition of BMP signaling in P-Cadherin positive hair progenitor cells leads to trichofolliculoma-like hair follicle neoplasias
... For example, germline mutation of BMP2 or BMP4 leads to embryonic lethality [9,10], whereas inhibition of BMP signaling by overexpressing Noggin under control of dif- ferent promoters, or by conditional knockout of BMP ...
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