Collagen Type I
Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading
... of collagen type II, collagen type I and YKL40 expression, which persisted throughout the ...elevated collagen type II, collagen type I and YKL40 mRNA ...
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Effect of angiotensin II receptor blocker on TGF-β1, MMP-1, and collagen type I and type III concentration in New Zealand rabbit urethral stricture model
... increases collagen formation through its effects on TGF-β1 and inhibition of collagenase ...Group I consisted of 15 rabbits with urethral stricture that did not undergo any treatment, group II consisted of ...
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<p>Effect of Intracorporeal Human Adipose–Derived Stem Cells (hADSCs) on Corpora Cavernosa Transforming Growth Factor β1 (TGFβ1) and Collagen Type I Concentration in Wistar Rat Priapism Model</p>
... a penile implant. Overall, these treatments focused only on restoration of erectile function, rather than prevention of fi brotic tissue formation. 6,7 In recent years, many stu- dies have shown the potential anti fi ...
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Hyaluronic acid increases tendon derived cell viability and collagen type I expression in vitro: Comparative study of four different Hyaluronic acid preparations by molecular weight
... HAPs. Collagen metabolism has been reported to be af- fected by HA [25, ...of collagen type I, in a dose dependent manner over 14 ...to collagen synthesis and ...of collagen ...
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Tissue turnover of collagen type I, III and elastin is elevated in the PCLS model of IPF and can be restored back to vehicle levels using a phosphodiesterase inhibitor
... that collagen type I and III are upregulated in lung tissue of IPF patients ...of type I collagen are significantly in- creased in supernatants from BLM treated animals, when ...
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Biochemical markers of bone collagen type I metabolism
... various collagen types (I, V, VI, XIV and XXIV) [12]. Collagen type I is the most abundant among proteins, making up 95% of the total bone collagen and 80% of the whole bone ...
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Collagen types I and II distribution: a relevant indicator for the functional properties of articular cartilage in immobilised and remobilised rabbit knee joints
... in collagen type I and type II distribution in the articular cartilage of immobilised and remobilised rabbit knee ...3. Collagen type I and type II in the articular ...
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Effect of Phase I Therapy on Salivary Carboxyterminal Telopetide of Type I Collagen in Chronic Periodontitis Patients
... Type I collagen comprises 90% of the organic matrix of bone and is the most abundant collagen in osseous ...of collagen, type I collagen also comprises three ...
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LAP (NF IL6) transactivates the collagen alpha 1(I) gene from a 5' regulatory region
... Although collagen is known to enhance hepatocyte differentiation and hepatocytes produce collagen in vivo, the transcriptional factors responsible for collagen type I gene expression in ...
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Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]
... Type I collagen comprises more than 90% of the organic bone ...contain type I colla- gen – for example, skin, tendon, and cornea – but bone has a much higher proportion and a much ...
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The trans-well coculture of human synovial mesenchymal stem cells with chondrocytes leads to self-organization, chondrogenic differentiation, and secretion of TGFβ
... follows: collagen type I (mouse monoclonalAb COL-1; abcam, Cambridge, UK) 1:500, collagen type II (rabbit polyclonalAb COL-2; abcam) 1:250, and collagen type X (mouse ...
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Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner
... Because collagen type I production increases several hundred-fold in pathological fibrosis [37], we evaluated whether the two pericyte subtypes were among the collagen-producing cells in ...
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Overexpression of Interleukin-18 Aggravates Cardiac Fibrosis and Diastolic Dysfunction in Fructose-Fed Rats
... myocardial collagen type I and III levels, mouse monoclonal antibodies to collagen type I and III (Abcam, Cambridge, UK) at a 1:500 dilution were ...
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Studies on engineered microenvironment for manipulating cells in tissue regeneration
... The effect of extracellular matrix ECM proteins such as collagen type I, collagen type IV, gelatin, laminin, fibronectin, Matrigel a mixture of laminin, collagen type IV, heparan sulfate[r] ...
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Tumour cells down-regulate CCN2 gene expression in co-cultured fibroblasts in a Smad7- and ERK-dependent manner
... and type I collagen gene expression in neighbouring fibroblasts via such secreted ...and type I collagen expression in fibro- blasts was dependent on the contacts with or close ...
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Safety, tolerability and efficacy of intra articular Progenza in knee osteoarthritis: a randomized double blind placebo controlled single ascending dose study
... of type I col- lagen; CTX-II: C-terminal telopeptide of type II collagen; CVs: coefficients of variation; ECG: electrocardiogram; HA: hyaluronic acid; IA: intra-articular; IP: investigational ...
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Characterization of the Interaction Between Bone Sialoprotein and Type I Collagen
... to type I collagen (14, ...the collagen molecule at a site with a surface chemistry that is, at least in part, ...hydrophobic. Type I collagen has an isoelectric point of ...
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Original Article Protective effects of adipose-derived stem cells secretome on human dermal fibroblasts from ageing damages
... of collagen I, collagen III and ...of collagen I, collagen III and elastin, so did UVB, except for its induction of elastin mRNA expres- ...
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EGR1 controls divergent cellular responses of distinctive nucleus pulposus cell types
... the NP harbors immature cells with somatic stem cell- like properties [8–10]. We previously reported on a unique experimental immortalization approach to ad- dress the issue of NP cellular heterogeneity [6]. We were able ...
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The Ehlers Danlos syndrome: on beyond collagens
... The first examples are gene knockouts of three small leucine-rich proteoglycans (SLRPs), decorin, fibro- modulin, and lumican (31–33). The phenotypes of all three knockouts include derangements in collagen fib- ...
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