Collagen, type I, alpha 1
STUDY OF RELATIONSHIP BETWEEN SP1 POLYMORPHISM IN THE COLLAGEN TYPE I ALPHA -1 (COLIA1) GENE AND OSTEOPROSIS IN PATIENTS WITH BETA-THALASSEMIA.
... the collagen one gene genotype diagnoses bone fracture by ways that are partly not dependent of bone mineral density ...example collagen type I alpha 1 (COLIAI), vitamin D ...
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Osteogenesis imperfecta The position of substitution for glycine by cysteine in the triple helical domain of the pro alpha 1(I) chains of type I collagen determines the clinical phenotype
... normal type I collagen molecules and additional molecules that had one or two alpha 1(I) chains that contained a cysteine residue within the triple-helical domain, a region from ...
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Diminished type I collagen synthesis and reduced alpha 1(I) collagen messenger RNA in cultured fibroblasts from patients with dominantly inherited (type I) osteogenesis imperfecta
... Type I osteogenesis imperfecta (OI) is characterized clinically by a moderate fracture frequency with minimal bone deformity and dominant ...of type I ...of type I ...elevated ...
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Frameshift mutation near the 3' end of the COL1A1 gene of type I collagen predicts an elongated Pro alpha 1(I) chain and results in osteogenesis imperfecta type I
... of type I collagen of which OI type I, an autosomal dominant condition, is the mildest and most common ...normal type I collagen as a result of decreased synthesis ...
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Prostaglandin E2 induces Skin Aging via E-prostanoid 1 in Normal Human Dermal Fibroblasts
... Abstract: Collagen type I production decreases with aging, leading to wrinkles and impaired skin ...inhibits collagen production and induces matrix metallopeptidase 1 (MMP1) expression ...
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Amino Acids Sequences Analysis on Collagen
... on collagen type I chains, the aims of the study were to identify the principal property component and to analyze the similarities within and between collagens on five ...on collagen ...
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Rescue of type I collagen-deficient phenotype by retroviral-vector-mediated transfer of human pro alpha 1(I) collagen gene into Mov-13 cells.
... The proalI collagen cDNA is functional because infection of Mov-13 cells with the vector rescued the mouse proa2I chain and restored type I collagen expression.. Our experiments demonstr[r] ...
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<p>Upregulation Of Protein Tyrosine Phosphatase Receptor Type C Associates To The Combination Of Hashimoto’s Thyroiditis And Papillary Thyroid Carcinoma And Is Predictive Of A Poor Prognosis</p>
... COL1A1, Collagen type I alpha 1 chain; DEGs, Differentially expressed genes; FC, Fold change; FDR, False positive rate; GAPDH, Glyceraldehyde- 3-phosphate dehydrogenase; GO, Gene ...
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Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice
... of collagen proportional area ( P < ...of collagen type I alpha 1, transforming growth factor β 1, tissue inhibitor of metalloproteinase 1 mRNA levels (for all P ...
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Osteogenesis imperfecta type IV Biochemical confirmation of genetic linkage to the pro alpha 2(I) gene of type I collagen
... (OI) type IV is genetically linked to the pro alpha 2(I) gene of type I collagen synthesize two populations of pro alpha 2(I) ...pro alpha 2(I) causes ...
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LAP (NF IL6) transactivates the collagen alpha 1(I) gene from a 5' regulatory region
... Although collagen is known to enhance hepatocyte differentiation and hepatocytes produce collagen in vivo, the transcriptional factors responsible for collagen type I gene expression in ...
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Mithramycin selectively inhibits collagen alpha 1(I) gene expression in human fibroblast
... the collagen-alpha 1(I) and -alpha 2(I) genes form the triple helical molecule collagen type I, which constitutes the major ECM protein in tissue ...The ...
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Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
... five collagen genes (type I collagen, alpha 2 chain [COL1A2], type II collagen alpha 1 chain [COL2A1], type III collagen alpha 1 ...
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Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
... five collagen genes (type I collagen, alpha 2 chain [COL1A2], type II collagen alpha 1 chain [COL2A1], type III collagen alpha 1 ...
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Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration
... Eagle, alpha modification; CD: Chondrodystrophic; COL1A1: Collagen, type I, α 1; COL2A1: Collagen, type II, α 1; DMEM: Dulbecco ’ s modified Eagle ’ s medium; FBS: ...
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Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients
... dehydrogenase (LDH) and prior systemic therapy. To assess any confounding effects, a multivariate Cox proportional-hazards regression model was used to calcu- late the independent HRs with 95%CI for OS and PFS for ...
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Effect of Phase I Therapy on Salivary Carboxyterminal Telopetide of Type I Collagen in Chronic Periodontitis Patients
... Although GCF is site specific, whole saliva represents a pooled sample of all periodontally involved sites and is potentially useful in detecting individuals at risk. Stimulated whole saliva is less suitable for ...
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Original Article Protective effects of adipose-derived stem cells secretome on human dermal fibroblasts from ageing damages
... human type I collagen (Forward: 5’-CCCCTGGAAAGAATGGAGATG-3’; Reverse: 5’- TCCAAACCACTGAAACCTCTG-3’); human type III collagen (Forward: 5’-AAGTCAAGGAGAAAGTG- GTCG-3’; Reverse: ...
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New diagnostic modalities and emerging treatments for neonatal bone disease
... Achondroplasia may be diagnosed antenatally on USS. In neonates, a wrist radiograph shows delayed bone age; catch-up to chronological age occurs in adolescence. MRI may demonstrate cervicomedullary compression at the ...
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Sintered dicalcium pyrophosphate treatment attenuates estrogen deficiency-associated disc degeneration in ovariectomized rats
... Background: Estrogen deficiency is associated with musculoskeletal disorders. Sintered dicalcium pyrophosphate (SDCP) is a novel antiosteoporotic agent. In this study, we examined its use for restoration of bone quality ...
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