Collagen type I alpha 1 chain
<p>Upregulation Of Protein Tyrosine Phosphatase Receptor Type C Associates To The Combination Of Hashimoto’s Thyroiditis And Papillary Thyroid Carcinoma And Is Predictive Of A Poor Prognosis</p>
... COL1A1, Collagen type I alpha 1 chain; DEGs, Differentially expressed genes; FC, Fold change; FDR, False positive rate; GAPDH, Glyceraldehyde- 3-phosphate dehydrogenase; GO, Gene ...
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STUDY OF RELATIONSHIP BETWEEN SP1 POLYMORPHISM IN THE COLLAGEN TYPE I ALPHA -1 (COLIA1) GENE AND OSTEOPROSIS IN PATIENTS WITH BETA-THALASSEMIA.
... Methods:-A total of 40 patients with β-thalassemia(21 females &19 males)aged 6-18 yearsand 40 healthy subjects cross matched with age and sex. Serum osteocalcin, serum alkaline phosphatase, calcium and DEXA were ...
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Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice
... Col1a1: Collagen type I alpha 1; CPT1A: Carnitine palmitoyltransferase 1A; FAS: Fatty acid synthase; FAT/CD36: Fatty acid translocase/cluster of differentiation 36; FATP5: Fatty acid ...
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Frameshift mutation near the 3' end of the COL1A1 gene of type I collagen predicts an elongated Pro alpha 1(I) chain and results in osteogenesis imperfecta type I
... polymerase chain reaction and sequence determination of the normal allele and of the mutant allele in the domain that normally contains the Eco RI site demonstrated a 5-bp deletion from the mutant ...pro ...
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Diminished type I collagen synthesis and reduced alpha 1(I) collagen messenger RNA in cultured fibroblasts from patients with dominantly inherited (type I) osteogenesis imperfecta
... Type I osteogenesis imperfecta (OI) is characterized clinically by a moderate fracture frequency with minimal bone deformity and dominant ...of type I ...of type I ...elevated ...
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Rescue of type I collagen-deficient phenotype by retroviral-vector-mediated transfer of human pro alpha 1(I) collagen gene into Mov-13 cells.
... The proalI collagen cDNA is functional because infection of Mov-13 cells with the vector rescued the mouse proa2I chain and restored type I collagen expression.. Our experiments demonstr[r] ...
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An osteopenic nonfracture syndrome with features of mild osteogenesis imperfecta associated with the substitution of a cysteine for glycine at triple helix position 43 in the pro alpha 1(I) chain of type I collagen
... osteoporosis in the proband. At age 38, while still premenopausal, she was found to have osteopenia, short stature, hypermobile joints, mild hyperelastic skin, mild scoliosis, and blue sclerae. There was no history of ...
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Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
... five collagen genes (type I collagen, alpha 2 chain [COL1A2], type II collagen alpha 1 chain [COL2A1], type III collagen ...
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Osteogenesis imperfecta type IV Biochemical confirmation of genetic linkage to the pro alpha 2(I) gene of type I collagen
... (OI) type IV is genetically linked to the pro alpha 2(I) gene of type I collagen synthesize two populations of pro alpha 2(I) ...pro alpha 2(I) causes ...
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Osteogenesis imperfecta The position of substitution for glycine by cysteine in the triple helical domain of the pro alpha 1(I) chains of type I collagen determines the clinical phenotype
... the alpha 1(I) chain are not invariably lethal and that their phenotypic effect largely depends on the nature of the substituting residue and its location in the ...
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Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
... five collagen genes (type I collagen, alpha 2 chain [COL1A2], type II collagen alpha 1 chain [COL2A1], type III collagen ...
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A synthetic peptide derived from the sequence of a type I collagen receptor inhibits type I collagen mediated platelet aggregation
... the type I col- lagen–induced platelet aggregation and the release of ATP in a dose-dependent ...platelet type III collagen receptor ...types I and III collagen– induced platelet ...
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Orbital dermatofibrosarcoma protuberans with intracranial extension preceded by recurrent leiomyoma of the orbit: a case report
... Dermatofibrosarcoma protuberans (DFSP) is a rare spin- dle cell tumor [1]. It accounts for less than 0.1% of all the malignant lesions and only 1% of all soft tissue sar- comas [2,3]. It is a cutaneous ...
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New insights into the pathogenesis of glucocorticoid induced avascular necrosis: microarray analysis of gene expression in a rat model
... G1, alpha-2-macroglob- ulin gene was particularly found to be overexpressed when comparing steroid-treated Wistar Kyoto rats which had developed ANFH (G2) to placebo rats (G1) (FC = ...0.0005). Collagen ...
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Coexpression of the collagen binding stress protein HSP47 gene and the alpha 1(I) and alpha 1(III) collagen genes in carbon tetrachloride induced rat liver fibrosis
... a collagen-binding stress protein and is assumed to act as a collagen-specific molecular chaperone during the biosynthesis and secretion of procollagen in the living ...of collagen in several cell ...
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Collagen and Collagen derived Fragments Are Chemotactic for Tumor Cells
... in collagen such as liver, lungs, and bone are frequently sites of tumor cell ...to collagen in ...the collagen helix caused similar ...that collagen or collagen fragments released ...
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d alpha tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts Modulation of constitutive collagen gene expression by lipid peroxidation
... stimulates collagen gene transcription in cultured fibroblasts, and this effect is mediated through the induction of lipid peroxidation by ascorbic ...of collagen production, but the mechanisms of ...
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Prostaglandin E2 induces Skin Aging via E-prostanoid 1 in Normal Human Dermal Fibroblasts
... NHDFs, I performed small interfering RNA (siRNA)-mediated EP1 knockdown experiments in ...antagonist, I observed that the inhibition efficiency of each antagonist against PGE2 binding by EP1–EP4 was not ...
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Mithramycin selectively inhibits collagen alpha 1(I) gene expression in human fibroblast
... the type I collagen gene highly depends on its GC- rich regulatory elements, and further, that these elements can be differentially blocked, thereby changing the balance between ECM structural and ...
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Deletions in the COL4A5 collagen gene in X linked Alport syndrome Characterization of the pathological transcripts in nonrenal cells and correlation with disease expression
... The type IV collagen alpha 5 chain (COL4A5) gene of 88 unrelated male patients with X- linked Alport syndrome was tested for major gene rearrangements by Southern blot analysis, using COL4A5 ...
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