collapsin response mediator protein-1
Identification and structural analysis of C-terminally truncated collapsin response mediator protein-2 in a murine model of prion diseases
... Considering the increasing ratio of CRMP-2- Δ C to full- length CRMP-2 in the late stages of prion disease in our model (Figure 4), we asked whether CRMP-2-ΔC would affect the morphology of the neurites. Plasmids ...
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Regulation of centrosome movements by Numb and the Collapsin Response Mediator Protein during Drosophila sensory progenitor asymmetric division
... 2). This shows that Numb is necessary to promote an early posterior apical centrosome movement. Furthermore, the overexpression of Numb induces a premature movement of both the anterior and the posterior centrosomes, and ...
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Collapsin response mediator protein 4 promotor methylation level as a potential predictor for diagnosing primary malignant lymphoma of the prostate
... prostate secondary lymphoma cannot be identified by morphology and IHC and must be combined with clinical manifestations, imaging data and lymph node and bone marrow biopsies to comprehensively diagnose. Moreo- ver, the ...
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Silencing collapsin response mediator protein-2 reprograms macrophage phenotype and improves infarct healing in experimental myocardial infarction model
... To eliminate blood contamination, hearts were perfused with ice-cold PBS after mice were euthanized. Hearts were removed, rinsed in PBS, embedded in O.C.T. com- pound (Sakura Finetek), and frozen in an isopentane bath on ...
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Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders
... containing 1% Triton-X 100, homogenized using a microgrinder, and centrifuged at 10,000 rpm for 10 minutes to clear insoluble ...and protein content in the total cell lysates was determined using the ...
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Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy
... shock protein 60 (hsp60) and collapsin response mediator protein 2 (CRMP2) as possible autoantigens frequently observed in patients with CAR, MAR and ...
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TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation
... the collapsin response mediator protein 2 (CRMP2) SUMO-incompetent mutant protein (CRMP2-K374A), which causes a significant reduction in Na V ...
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Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias
... Collapsin response mediator protein-2 (CRMP2) is the first identified member of the collapsin response medi- ator protein (CRMP) family ...by protein phosphatase 2A ...
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Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2
... Figure 1 Decreased GSK3 β activity through downregulation of P-Tyr216 is related to increased axonal ...CRMP-2, collapsin response mediator protein 2; DRG, dorsal root ganglia; GSK3 β , ...
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A case of paraneoplastic optic neuropathy and outer retinitis positive for autoantibodies against collapsin response mediator protein-5, recoverin, and α-enolase
... Patients with CAR basically exhibit no abnormal retinal appearances in the initial stage and may later develop diffuse pigment epithelial degeneration similar to retin- itis pigmentosa together with photoreceptor ...
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Functional characterization of DJ-1 : an oxidative response protein
... Meulener et. al. used P-transposition genetic deletion to generate double knockout flies deficient in both DJ-1 and DJ-1 gene loci (Meulener et al. 2005). This strain of drosophila did not show any motor ...
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Mediator Subunit MED25 Physically Interacts with PHYTOCHROME INTERACTING FACTOR 4PIF4 to Regulate Shade-induced Hypocotyl Elongation in Tomato
... Mediator complex subunit MED25 was shown to regulate hypocotyl elongation in response 223.. to shade (Cerdan and Chory, 2003)..[r] ...
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The immune response mediator genes polymorphic variants as predictors of the etanercept efficacy in juvenile idiopathic arthritis
... associated protein 4 (CTLA4), nuclear factor kappa B subunit 1 (NF-κB1), protein tyrosine phosphatase, non-receptor type 22 (PTPN22)), as well as their genes polymorphisms are believed to play an ...
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N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling
... domains, which combined mutually to form mature Notch dimers. Then the activation of Notch signaling by its ligands would lead to sequential cleavages by tumor necrosis factor-a-converting enzyme (S2) and r-secretase ...
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FAT10: a Novel Mediator of Vpr-Induced Apoptosis in Human Immunodeficiency Virus-Associated Nephropathy
... ubiquitin-like protein FAT10 as a critical mediator of Vpr-induced apoptosis in RTEC and define Vpr as the HIV-1 gene primarily respon- sible for FAT10 ...
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Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells
... Figure 1, or their mutant where putative target sites were mutated into alanine (in vitro synthesized by Thermo), were added to the kinase reaction (1 mg per reaction) along with 1 µM ATP, and ...
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Review on: Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy
... The first description of cancer is found in an Egyptian papyrus and dates back to approximately 1600 BC [1]. It is a cluster of diseases involving alterations in the status and expression of multiple genes that ...
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Original Article Blocking HMGB1 signal pathway protects early radiation-induced lung injury
... p50NF-κB protein expression in mice lung tissues was detected by Western blot ...inflammatory response, and thereby decreased the degree of alveolitis of irradiated lung ...
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Molecular Characterization of the Dbf4/Drf1 Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts
... 2.2.9 Cell Culture and Immunofluorescence—XTC-2 cells were grown on poly-D- lysine-coated coverslips in 61% Leibovitz's (L-15) medium supplemented with 10% fetal calf serum and antibiotics. Caffeine-treated cells were ...
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Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection
... Cloning of Tab182. Total cellular RNA was isolated from a lymphoblastoid cell line from a normal individual (cell line provided by the Coriell Institute for Medical Research) by using the Qiagen RNeasy minikit and was ...
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