colony stimulating factor 1
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy
... CSF1: Colony-stimulating factor 1; CSF1R: Colony-stimulating factor 1 receptor; CTLA4: Cytotoxic T-lymphocyte- associated protein 4; DC: Dendritic cells; DLT: ...
13
Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony stimulating factor 1, and recombinant murine granulocyte macrophage colony stimulating factor on myelopoiesis in mice
... preparations did not contain detectable endotoxin (less than 0.1 ng). Mice pretreated with LF were more sensitive to the effects of CSF. In mice pretreated with LF, 2,000 U IL-3 or 20,000 U CSF-1 significantly ...
11
Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
... CSF1: colony-stimulating factor 1; CSF1R: colony-stimulating factor 1 receptor; CR: complete response; CTLA-4: cytotoxic T-lymphocyte associated protein 4; CTLs: ...
16
Isoforms of the granulocyte-macrophage colony-stimulating factor receptor
... The haemopoietic system develops from mesenchymal tissue in at least two waves. The first, and most primitive, occurs in the yolk sac where blood islands and the first vascular cells develop in close proximity, ...
240
Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP 1, and the monocyte colony stimulating factor, CSF 1, in response to tumor necrosis factor alpha and immunoglobulin G Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH) dependent oxidase
... The potential involvement of reactive oxygen species in the expression of genes involved in immune response was examined in mesangial cells. Tumor necrosis factor (TNF-alpha) and aggregated (aggr.) IgG increased ...
9
Granulocyte Colony-Stimulating Factor Serum and Urine Concentrations in Neutropenic Neonates Before and After Intravenous Administration of Recombinant Granulocyte Colony-Stimulating Factor
... group 1) were not infected but likely had hyporegenera- tive neutropenia (4 were born after pregnancy-induced hypertension/intrauterine growth restriction, and 1 had Rh hemolytic ...group 1, ...
8
Original Article Increased circulating macrophage-colony stimulating factor and monocyte chemoattractant protein-1 are predictors of in-hospital events in Chinese patients with unstable angina pectoris
... Table 1). MCSF and MCP-1 of patients with type II lesions were sig- nificantly higher than that with type I and type III ...Figure 1), but the levels of MCSF and MCP-1 were not different among ...
6
A Randomized Trial of Granulocyte-Macrophage Colony-Stimulating Factor in Neonates With Sepsis and Neutropenia
... adequate renal and liver function, and had documented serum creatinine levels ⱕ2.0 mg/dL and serum glutamic-pyruvic transaminase ⱕ 3 times normal. Exclusion criteria were the pres- ence of major congenital anomaly or ...
8
Pim kinases in hematological malignancies: where are we now and where are we going?
... The proviral insertion in murine (Pim) lymphoma family proteins, whose gene locus was discovered as a proviral integration site for Moloney murine leukemia virus infec- tion, consists of three serine/threonine kinase ...
9
Interleukin 1 stimulates T lymphocytes to produce granulocyte monocyte colony stimulating factor
... interleukin 1 (IL-1), as indicated by T cell production of CSF, which induces growth of myeloid progenitor cells into neutrophil, eosinophil, and monocyte ...
5
Granulocyte colony stimulating factor (G CSF) and granulocyte macrophage colony stimulating factor (GM CSF) for sepsis: a meta analysis
... mortality: 1 trial [43]; 28-day mortality: 2 trials [42,46]; in-hospital mor- tality: 1 trial [47]; reverse rate from infection: 2 trials [37,38]; others: 1 trial ...
12
Granulocyte colony stimulating factor producing rectal cancer
... G-CSF-producing cancer has been reported to occur in various organs, especially in the lung. Histologically, more than half of the reported cases of G-CSF-producing lung cancer have been large cell carcinoma [1]. ...
5
Host microenvironment in breast cancer development Inflammatory and immune cells in tumour angiogenesis and arteriogenesis
... important factor responsible for increased macrophage infiltration in breast cancer is the macrophage colony-stimulating factor (CSF)-1; this is a haematopoietic growth factor ...
6
A screen for peptide agonists of the G CSF receptor
... Granulocyte-colony stimulating factor (G-CSF) is one the most widely employed protein drugs. It is mostly used for counteracting neutropenia in patients receiving chemotherapy [1], but also ...
6
Acute radiation syndrome (ARS) – treatment of the reduced host defense
... Figure 2 (A) The lung is the most vulnerable vital organ when exposed to acute irradiation because of the “double hit” radiation exposure, ie, a combined exposure of inhaled particles (P) and from gamma radiation (γ) ...
11
Increased granulocyte colony stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony stimulating factor receptor mutation derived from a patient with severe congenital neutropenia
... with 1% low endotoxin bovine serum albumin (Sigma Chemical ...serum, 1 mM L-glutamine, and 10 m g/mL ciprofloxacin, and cultured at 37 8 C and 5% CO 2 for 48 h in the presence or absence of 100 ng/mL ...
11
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
... granulocyte-macrophage colony-stimulating factor (GM-CSF), stimulate the generation of M1 macro- phages, from either naïve M0 or polarized M2 macro- phages ...box 1 (HMGB1), are also found to ...
10
Role of Granulocyte Macrophage Colony Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection
... ml; BioLegend). Brefeldin A (GolgiPlug; BD Biosciences) was added to the cultures 1 h after the addition of exogenous stimuli. Cells were next incubated with CD16/CD32 (FcBlock; BD Biosciences). Surface staining ...
18
Macrophage and nerve interaction in endometriosis
... lesion and modulating the menstrual cycle indirectly [112]. Due to the molecular nature of endometriosis, the limited efficacy of currently available hormonal drugs, and their potential adverse effects, there is an ...
11
Recombinant murine granulocyte macrophage colony stimulating factor has megakaryocyte colony stimulating activity and augments megakaryocyte colony stimulation by interleukin 3
... megakaryocyte colony formation. The dose-response curve for megakaryocyte colony induction with rGM-CSF showed plateau megakaryocyte stimulation at 9 ...megakaryocyte colony induction) was added to ...
6