colony-stimulating factor-1 (macrophage)
Mechanisms of amphibian macrophage development: characterization of the Xenopus laevis colony stimulating factor 1 receptor
... ABSTRACT Macrophage-lineage cells are indispensable to vertebrate homeostasis and ...turn, macrophage development is largely regulated through colony-stimulating factor-1 (CSF1) ...
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A study of the granulocyte-macrophage colony stimulating factor receptor (GM-CSFR) in leukaemia
... Phase 1 and 2 introns interrupt the reading frame after the first and second nucleotides of codons, ...phase 1 introns, without exception, and each domain is roughly halved by intervening introns, of phase ...
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Granulocyte colony stimulating factor (G CSF) and granulocyte macrophage colony stimulating factor (GM CSF) for sepsis: a meta analysis
... mortality: 1 trial [43]; 28-day mortality: 2 trials [42,46]; in-hospital mor- tality: 1 trial [47]; reverse rate from infection: 2 trials [37,38]; others: 1 trial ...
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Anti Granulocyte Macrophage Colony Stimulating Factor Autoantibodies Are a Risk Factor for Central Nervous System Infection by Cryptococcus gattii in Otherwise Immunocompetent Patients
... Reactivation of the fungus after long-term dormancy has been suggested not only in C. neoformans (38) but also in C. gattii (39) as shown by molecular typing techniques. It is possible that con- comitant immune ...
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Original Article Increased circulating macrophage-colony stimulating factor and monocyte chemoattractant protein-1 are predictors of in-hospital events in Chinese patients with unstable angina pectoris
... Table 1). MCSF and MCP-1 of patients with type II lesions were sig- nificantly higher than that with type I and type III ...Figure 1), but the levels of MCSF and MCP-1 were not different among ...
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Transcriptional and posttranscriptional regulation of macrophage specific colony stimulating factor gene expression by tumor necrosis factor Involvement of arachidonic acid metabolites
... monocytic differentiation. CSF-1 transcripts were undetectable in uninduced HL-60 cells, reached maximal levels by 3 h of exposure to TNF, and returned to that of control cells by 24 h. Transcriptional run-on ...
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Isoforms of the granulocyte-macrophage colony-stimulating factor receptor
... GM-CSFRa 1) the first variant isoform to be described was a potentially soluble species that lacks a transmembrane domain (designated here hGM-CSFRa2) 147,148 Although these two publications disagreed on the exact ...
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Pim kinases in hematological malignancies: where are we now and where are we going?
... The proviral insertion in murine (Pim) lymphoma family proteins, whose gene locus was discovered as a proviral integration site for Moloney murine leukemia virus infec- tion, consists of three serine/threonine kinase ...
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Current status of granulocyte–macrophage colony-stimulating factor in the immunotherapy of melanoma
... GM-CSF has been evaluated as an adjuvant, systemic monotherapy following regional lymphadenectomy, to prevent or to delay recurrence in high-risk stage III pa- tients (Table 1). In a phase 2 study, there were ...
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The Immunosuppressive Microenvironment of Classic Hodgkin Lymphoma and Therapeutic Approaches to Counter It
... [16]. Colony-stimulating factor 1 receptor (CSFR- 1), the receptor of both M-CSF and IL-34 [115], is expressed on monocytes and on HRS cells and is associated with an increased number ...
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Myeloid-derived suppressor cells in hematological malignancies: friends or foes
... Granulocyte colony- stimulating factor; GM-CSF: Granulocyte-macrophage colony-stimulating fac- tor; G-PBSC: G-CSF peripheral blood stem cells harvest; GRFS: GVHD and relapse-free ...
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Potentiation by granulocyte macrophage colony stimulating factor of lipopolysaccharide toxicity in mice
... Polyclonal anti-GM-CSF IgG protected against septic liver failure in this model and attenuated serum TNF concentrations. In vitro an ex vivo experiments revealed that after GM-CSF pretreatment LPS-induced IL-1 ...
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Effect of granulocyte macrophage colony stimulating factor in experimental visceral leishmaniasis
... with 1-5 micrograms/d murine GM-CSF induced three dose-related effects: peripheral blood leukocytosis, preferential accumulation of myelomonocytic cells at visceral foci of infection, and leishmanicidal activity ...
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Adipocyte macrophage colony stimulating factor is a mediator of adipose tissue growth
... Adenoviral-mediated gene transfer of MCSF to rabbit adi- pose tissue in vivo. All animals tolerated the gene transfer procedures well. Successful transfer of b -galactosidase was de- tected in the Ad- b gal–transduced ...
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A Randomized Trial of Granulocyte-Macrophage Colony-Stimulating Factor in Neonates With Sepsis and Neutropenia
... Twenty-seven neonates in the GM-CSF-treated groups and 21 neonates in the conventionally treated groups survived to hospital discharge. There were significant differences in mortality rates between the GM-CSF-treated and ...
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Role of Granulocyte Macrophage Colony Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection
... ml; BioLegend). Brefeldin A (GolgiPlug; BD Biosciences) was added to the cultures 1 h after the addition of exogenous stimuli. Cells were next incubated with CD16/CD32 (FcBlock; BD Biosciences). Surface staining ...
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Host microenvironment in breast cancer development Inflammatory and immune cells in tumour angiogenesis and arteriogenesis
... important factor responsible for increased macrophage infiltration in breast cancer is the macrophage colony-stimulating factor (CSF)-1; this is a haematopoietic growth ...
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Acute radiation syndrome (ARS) – treatment of the reduced host defense
... Figure 2 (A) The lung is the most vulnerable vital organ when exposed to acute irradiation because of the “double hit” radiation exposure, ie, a combined exposure of inhaled particles (P) and from gamma radiation (γ) ...
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Macrophages: friend or foe in idiopathic pulmonary fibrosis?
... Pulmonary macrophage populations are classified into two main categories: alveolar macrophages (AMs), which strategically reside in the alveoli, and interstitial macro- phages (IMs), which are located within the ...
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Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system
... growth factor; G-CSF: Granulocyte colony-stimulating factor; GM-CSF: Granulocyte macrophage colony- stimulating factor; Ig: Immunoglobulin; INF: Interferon; IL: ...
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