Colorectal carcinogenesis
Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition
... human colorectal cancer tissues and colon ...in colorectal cancer cells can inhibit cell proliferation and tumor formation, induce G2/M arrest, and lead to ...human colorectal cancer tissues and ...
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Original Article Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis
... with colorectal cancer is ...in colorectal carcinogenesis by immunohistostaining colorectal tissues (normal, low grade adenoma, high grade adenoma, and ...during carcinogenesis, which ...
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Molecular cytogenetic analysis applied to multiple endocrine neoplasia type 1 and colorectal carcinogenesis
... The basis for investigation of chromosome 18q allelic loss including the DCC gene at 18q21 is the frequent alterations involving this region that are implicated in the progression of colorectal ...
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miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
... Caspases 3 and 7 as miR-224 Targets in Colorectal Carcinogenesis We have previously reported that miR-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7. Our luciferase ...
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MANGO (MANGIFERA INDICA CV. AZÚCAR) ANTIINFLAMMATORY AND CHEMOPREVENTIVE ROLE DURING COLORECTAL CARCINOGENESIS
... during colorectal carcinogenesis, have shown changes of pro-inflammatory cytokines interleukin-1beta (IL1b), Tumor Necrosis Factor a (TNFa), enzymes (COX2, inducible nitric oxide synthase (NOS2)) and ...
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Alterations in genomic organization and gene expression in colorectal carcinogenesis
... the colorectal cancer cell line 1196 (Leach, et a l , 1993), this cyclin has been shown to be indirectly responsible for pRB phosphorylation (Ewen, et a l , 1993) ...primary colorectal tumours has yet to be ...
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CD80-CD28 signaling controls the progression of inflammatory colorectal carcinogenesis
... Because the main immune surveillance mecha- nisms seemed to occur at an early stage following the inflammatory insult in the AOM-DSS model of colonic inflammatory-mediated carcinogenesis, we analyzed the ...
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Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine.
... The antiproliferative and cytotoxic effects of M. polymorphum have been described on U251 tumor lineage (glioma), UACC-62 (melanoma), MCF-7 (breast cancer), NCI-ADR/ RES (drug-resistant ovarian cancer), 786.0 (kidney), ...
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Blocking TNF α in mice reduces colorectal carcinogenesis associated with chronic colitis
... The inflammatory bowel disease ulcerative colitis (UC) frequently progresses to colon cancer. To under- stand the mechanisms by which UC patients develop colon carcinomas, we used a mouse model of the disease whereby ...
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TCF4 MAY ACT AS A TUMOR SUPPRESSOR GENE IN COLORECTAL CARCINOGENESIS
... Colorectal cancer (CRC) is the major cause of mortality and morbidity worldwide as it causes 655,000 deaths worldwide per year (World Health Organization, 2006; American Cancer Society, 2008). It is the fourth ...
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MiR-194 Deregulation Contributes To Colorectal Carcinogenesis via Targeting AKT2 Pathway
... HCT116 cell line, which has highly invasive and metastasis ability, was used to construct an orthotopic mice model for research of the in vivo invasion of human colon cancer cells previously [24]. However, it’s very ...
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Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway
... We further investigated the underlying mechanism of upregulating GEP on CRC. A series of in vitro and in vivo experiments confirmed GEP as an oncogenic factor in CRC. Notably, a decreased GEP level by RNA interference ...
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Colorectal Carcinogenesis from Gut-associated Lymphoid Tissue Clinical and Experimental Documentation
... tubulovillous and villous adenomas or carcinomas. Perse and Cerar [42] also classified colonic tumours in DMH/AOM-treated rats into tubular, villous, or tubulovillous adenomas or carcinomas. Adenocarcinomas were ...
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Effect of dietary components on miRNA and colorectal carcinogenesis
... in colorectal adenoma compared to normal colon sample ...on colorectal cancer invasion and metastasis in conjunction with IL-6R, ZNF281, MET, snail fam- ily zinc finger 1 and 2 (SNAI1, SNAI2) and β-catenin ...
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The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis
... For colon carcinogenesis protocol, 8–10 week-old mice (20 mice/genotype) were given 10 mg/kg Azoxymethane (AOM) (Sigma Chemical Co., St. Louis, MO, USA) i.p. (day 0) and 1.5% DSS (MW:36, 000–50, 000, ICN ...
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A cellular based model of the colon crypt suggests novel effects forApc phenotype in colorectal carcinogenesis
... A number of non-intuitive results arose from the simulations carried out with our extended crypt model: The increase in cell-membrane adhesion seen in Apc mutation allows mutated c[r] ...
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Original Article Inhibition of SALL4 suppresses carcinogenesis of colorectal cancer via regulating Gli1 expression
... Besides the anti-carcinogenesis effects we found by SALL4 inhibition, we intended to figure out the internal mechanism which mediated SALL4’s actions. Gli1 was a downstream tran- scriptional factor of Sonic ...
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Download Download PDF
... Background: Colorectal cancer is the third most common cancer in the United States with a mortality rate ranked second in ...reduce colorectal cancer ...in colorectal carcinogenesis by using ...
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Text ABSTRACT pdf
... Hagiwara,A. H. Yosindo, T. Icihara, M. Kawabe, S. Tamano, H. Aoki, T. Koda, M. Nakamura, K. Imaida, N. Ito dan T. Shira. 2002. Prevention by Natural Food Anthocyanins, Purple Sweet Potato Color and Red Cabbage Color of ...
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Association between pre-miR-27a functional polymorphism and risk of colorectal cancer in north Chinese Han population
... including colorectal cancer (CRC), and rs895819 within pre-miR-27a may affect its secondary struc- ture, leading to its aberrant expression and dysfunction of its targeted ...in colorectal ...
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