Comparative Genomic Hybridization
Genomic profiling using array comparative genomic hybridization define distinct subtypes of diffuse large b-cell lymphoma: a review of the literature
... array comparative genomic hybridization (aCGH) have revealed recurrent copy number alterations (CNA), as well as prognostic indicators in a number of DLBCL subtypes [22-27], for example, in a recent ...
12
Prenatal diagnosis of Wolf-Hirschhorn syndrome confirmed by comparative genomic hybridization array: report of two cases and review of the literature
... array comparative genomic hybridization (a-CGH) increased the detection rate of submicroscopic chromo- somal aberrations that could also lead to a WHS pheno- ...
7
Array Comparative Genomic Hybridization as a Diagnostic Tool in Cancer
... Array comparative genomic hybridization (aCGH) is a specific molecular cy- togenetic method that combines CGH and DNA microarrays and enables whole molecular cytogenetic ...blinded genomic DNA ...
7
Chromosomal Aberrations in ETV6/RUNX1-positive Childhood Acute Lymphoblastic Leukemia using 244K Oligonucleotide Array Comparative Genomic Hybridization
... array-based Comparative Genomic Hybridization (array-CGH) was used to study eleven ETV6/RUNX1-positive childhood acute lymphoblastic leukemia (ALL) ...
6
Yield of comparative genomic hybridization microarray in pediatric neurology practice
... Array comparative genomic hybridization (aCGH) is a ge- netic technology used to identify copy number variants (CNVs). A CNV is a duplicated or deleted segment of DNA, greater than 1 kb in size, ...
11
Molecular genetic analysis of cervical cancer using fluorescence in situ hybridization and comparative genomic hybridization
... In 1991, Srivatsan et al. studied 33 primary cervical tumour samples with RFLP, using chromosome 11 specific polymorphic DNA markers. Comparative analysis of tumour DNA with normal DNA was performed in 15 cases. ...
319
Prenatal diagnosis of a de novo interstitial deletion of 11q (11q22.3 → q23.3) associated with abnormal ultrasound findings by array comparative genomic hybridization
... Array comparative gen- omic hybridization (array CGH) has been introduced in prenatal diagnosis to rapidly detect genomewide gains and losses with higher resolution ...
6
Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization
... cancer by deletion-induced down-expression of tumor suppressor genes or amplification and activation of oncogenes. In colorectal cancer the most frequent chromosomal aberrations were gains at 7p, 7q, 8q, 13q, and 20q and ...
10
Molecular characterization of a rare analphoid supernumerary marker chromosome derived from 7q35 → qter: a case report
... Chromosomal comparative genomic hybridization (cCGH) Metaphase spreads were prepared from phytohemagglu- tinin-stimulated lymphocytes from healthy individuals, ac- cording to standard ...procedures. ...
7
MET in glioma: signaling pathways and targeted therapies
... ATRX: α -thalassemia/mental retardation syndrome X-linked gene; CGH: Comparative genomic hybridization; FISH: Fluorescence in situ hybridization; GBM: Glioblastoma multiforme; GSCs: Glio[r] ...
13
13q mosaic deletion including RB1 associated to mild phenotype and no cancer outcome – case report and review of the literature
... Array Comparative Genomic Hybridization on blood identified a mosaic ...Situ Hybridization (iFISH) on both blood genomic DNA and cultured/uncultured blood lymphocytes, ...
8
A microdeletion in the GRHL2 Gene in two unrelated patients with congenital fibrosis of the extra ocular muscles
... elsewhere [8]. Studies in the past have associated syn- dromic CCDD with chromosomal copy number varia- tions (CNVs) including deletion(s) [9, 10], duplication(s), translocation(s) [11] and the presence of 22 marker ...
5
16p13.3 duplication associated with non-syndromic pierre robin sequence with incomplete penetrance
... array-comparative genomic hybridization (array CGH) test was performed to determine the chromosomal origin of the sSMC, as well as other possible chromosome abnormalities which may have been missed ...
10
Characterization of Chromosomal Abnormalities in Cancer by Spectral Karyotyping
... situ hybridization technique (FISH) enabled detection of chromosomal microdeletions and structural abnormalities ...as comparative genomic hybridization (17) and spectral karyotyping (SKY) ...
10
Submicroscopic copy-number variations associated with 46,XY disorders of sex development
... array-based comparative genomic hybridization (aCGH), multiplex ligation-dependent probe amplification (MLPA), and next-generation sequencing (NGS), have enabled high-throughput analysis of clinical ...
7
Porphyromonas gingivalis Strain Diversity
... (i.e., comparative genomic hybridization [CGH] analysis), to compare the relatedness of the strains on the basis of their genome content to phylogeny on the basis of the sequence of a single locus ...
9
Copy number variants in a sample of patients with psychotic disorders: is standard screening relevant for actual clinical practice?
... array comparative genomic hybridization, studies on the putative genetic etiology of schizophrenia have focused on the detection of copy number variants (CNVs), ie, microdeletions and/or ...
6
Array-CGH characterization and genotype-phenotype analysis in a patient with a ring chromosome 6
... Array-Comparative Genomic Hybridization (Array-CGH) The array-Comparative Genomic Hybridization (aCGH) study was performed using the Agilent Human Genome CGH Microarray Kit ...
7
A 18p11.23-p11.31 microduplication in a boy with psychomotor delay, cerebellar vermis hypoplasia, chorioretinal coloboma, deafness and GH deficiency
... array comparative genomic hybridization (aCGH), not overlapping with the previously described one, encompassing three genes, namely ARHGAP28 , LINC00668 and LAMA1 in a 10 year-old boy with moderate ...
6
Diagnostic utility of novel combined arrays for genome-wide simultaneous detection of aneuploidy and uniparental isodisomy in losses of pregnancy
... routines decades ago. Since then, clinical geneticists have been facing two major diagnostic concerns: First of all, mosaic constellations in embryo or placenta remain a profound analytical problem related to POC ...
9