Competitive Endogenous RNA
LncRNA TUBA4B functions as a competitive endogenous RNA to inhibit gastric cancer progression by elevating PTEN via sponging miR-214 and miR-216a/b
... a competitive endogenous RNA (ceRNA) that could physically bind to and sequester miR-214 and miR-216a/b to increase the expression of their common downstream target PTEN, result- ing in inactivation ...
12
Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma
... OS is a common bone malignancy [1]. Current treat- ments for OS are mainly surgery and chemotherapy, but patient prognosis remains unsatisfactory [4]. Due to their stable structure, circRNAs may be a new strategy in the ...
12
Competitive endogenous RNA (ceRNA) regulation network of lncRNAs, miRNAs, and mRNAs in Wilms tumour
... To further investigate the related cellular mechanisms in WT, GO and KEGG analyses of 143 DEGs in the ceRNA network were performed. The GO analysis re- sults showed that the DEGs were mainly enriched in terms related to ...
10
Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma
... the RNA-induced silencing complex that is required for miRNAs-induced gene silencing, and the targets of miR- NAs can be isolated from complex after Ago2 ...
15
Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells
... Competitive endogenous RNAs (ceRNAs) are defined as the transcripts that share common miRNAs and can core- gulate each other’s expression ...non-coding RNA UICLM can facilitate colorectal cancer ...
18
Long non-coding RNA HOTAIR functions as a competitive endogenous RNA to regulate PRAF2 expression by sponging miR-326 in cutaneous squamous cell carcinoma
... relative RNA expression in immunoprecipitates was measured via qRT-PCR, which revealed that a large number of HOTAIR RNAs were enriched by anti-AGO2 antibodies in cells in contrast to IgG ...
13
Identification of prognostic biomarkers in glioblastoma using a long non-coding RNA-mediated, competitive endogenous RNA network
... in RNA processing and cell cycle-related functions, and was significantly associated with survival in GBM ...a competitive sub-network within the LMCN, we determined that MCM3AP-AS and MIR17HG were involved ...
11
Identification of a three-long noncoding RNA prognostic model involved competitive endogenous RNA in kidney renal clear cell carcinoma
... with RNA-sequencing data and clinical information, 514 KIRC patients were sub- jected to subsequent analyses after excluded according to the following criteria: (1) patients without survival infor- mation ...
15
The prognostic value of long noncoding RNA SNHG16 on clinical outcomes in human cancers: a systematic review and meta-analysis
... ceRNA: competitive endogenous RNA; CI: confidence interval; CNKI: China National Knowledge Infrastructure; DFS: disease-free survival; DM: distant metastasis; E2F1: E2F transcription factor 1; E2F5: ...
14
<p>Construction and Analysis of a Long Non-Coding RNA-Associated Competing Endogenous RNA Network Identified Potential Prognostic Biomarkers in Luminal Breast Cancer</p>
... Recently, competitive endogenous RNA (ceRNA), as a whole view of transcription, has gradually become a useful tool for identifying prognostic ...The competitive relationship in fl uences the ...
12
Identification of enteroviruses in clinical specimens by competitive PCR followed by genetic typing using sequence analysis
... Most PCR assays described for enteroviruses to date use primers from the conserved 5 9 -UTR of the picornavirus ge- nome (15, 27). This allows for the detection of both enterovi- ruses and rhinoviruses by a single set of ...
6
Characterization of human endogenous retroviral envelope RNA transcripts.
... DNA sequence analysis of a partial cDNA clone, pPL1, of the 1.7-kb RNA has revealed that in comparison with a cloned, full-length, endogenous provirus, 4-1, pPL1 contains a 938-bp deleti[r] ...
7
Long non-coding RNA and tumor hypoxia: new players ushered toward an old arena
... of RNA-targeting methods has provided tremendous opportunities to modulate lncRNAs for can- cer therapy [119, ...of RNA-based therapeutics show great potential to modulate lncRNA activity in diverse ways ...
19
Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma
... and had an unfavorable prognosis in patients with lung adenocarcinoma [54]. Gu et al. found that CCNB1 over- expression is closely related to poor survival in patients with HCC [55]. Knockdown of CCNB1 by RNA ...
12
Is the Triple Helix Model Suitable to Approach Low Density Regions Competitiveness? Insights from a Portuguese Case Study
... growth, competitive advantage and technological innovation, the operationalisation of innovation system concept was extended to a variety of levels: global ...to competitive advantage and economic ...
9
Tetrahymena Mutants With Short Telomeres
... Telomere length is dynamic in many organisms. Genetic screens that identify mutants with altered telomere lengths are essential if we are to understand how telomere length is regulated in vivo. In Tetrahymena ...
8
Amiloride Is a Competitive Inhibitor of Coxsackievirus B3 RNA Polymerase
... genomic RNA strands is initiated by attachment of two UMP nucleotides to a tyrosine residue of VPg, resulting in the production of VPg- ...genomic RNA strand (cis-acting replication element [CRE]) is used ...
11
Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
... In a variety of cancers, SNHG6 is highly expressed in can- cer tissues in contrast to noncancerous tissues. SNHG6 is also upregulated in the investigated cancer cell lines. Overexpressed SNHG6 arrests cell cycle and ...
10
Analyzing the lncRNA, miRNA, and mRNA-associated ceRNA networks to reveal potential prognostic biomarkers for glioblastoma multiforme
... Competing endogenous RNA; lncRNA: Long noncoding RNA; miRNA: microRNA; WGCNA: Weighted gene co‑repression network analysis; GO: Gene ontology; KEGG: Kyoto encyclopedia of genes and genomes; BP: ...
12
Infrastructures of systems biology that facilitate functional genomic study in rice
... The large number of expression files that have accu- mulated now enables co-expression analyses by cluster- ing genes that show similar expression patterns in various situations (Aoki et al. 2007; Usadel et al. 2009a, ...
17